Tcf21 (transcription factor 21) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tcf21 (transcription factor 21) Mus musculus
Analyze
Symbol: Tcf21
Name: transcription factor 21
RGD ID: 1552041
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in several processes, including metanephros development; regulation of transcription by RNA polymerase II; and skeletal muscle organ development. Acts upstream of or within several processes, including lung development; nephron development; and sex determination. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart and pericardium; and respiratory system. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHa; bHLHa23; ca; capsulin; ep; epc; epi; epicardin; Po; Pod; Pod-1; Pod1; podocyte-expressed 1; TCF-21
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391022,693,162 - 22,696,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1022,693,180 - 22,696,073 (-)EnsemblGRCm39 Ensembl
GRCm381022,817,263 - 22,820,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1022,817,281 - 22,820,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv371022,537,069 - 22,539,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361022,506,679 - 22,509,544 (-)NCBIMGSCv36mm8
Celera1023,754,029 - 23,756,913 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map1010.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (EXP)
cobalt atom  (EXP)
corticosterone  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
diquat  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
fenthion  (EXP)
folic acid  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hydrogen cyanide  (EXP)
kojic acid  (ISO)
L-methionine  (EXP)
Licarin A  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
potassium cyanide  (EXP)
potassium dichromate  (EXP)
propanal  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sulforaphane  (EXP)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
trichloroethene  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IEA)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal branching involved in ureteric bud morphogenesis  (IAGP)
abnormal eye morphology  (IEA)
abnormal glomerular capillary morphology  (IAGP)
abnormal heart apex morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney pelvis morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal kidney vasculature morphology  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal masticatory muscle morphology  (IAGP)
abnormal myogenesis  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary topology  (IAGP)
abnormal palatal shelf elevation  (IAGP)
abnormal peritubular capillary morphology  (IAGP)
abnormal placenta morphology  (IEA)
abnormal placenta vasculature  (IEA)
abnormal podocyte foot process morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal pterygoid muscle morphology  (IAGP)
abnormal pulmonary acinus morphology  (IAGP)
abnormal pulmonary alveolar sac morphology  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal spleen development  (IAGP)
abnormal spleen morphology  (IEA)
abnormal testis morphology  (IEA)
abnormal ureteric bud morphology  (IAGP)
abnormal ureteric bud tip morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
absent masseter muscle  (IAGP)
absent proximal convoluted tubule brush border  (IAGP)
absent pterygoid muscle  (IAGP)
absent pulmonary alveoli  (IAGP)
absent spleen  (IAGP)
absent temporalis muscle  (IAGP)
absent type II pneumocytes  (IAGP)
anophthalmia  (IEA)
cleft secondary palate  (IAGP)
cyanosis  (IAGP)
decreased nephron number  (IAGP)
decreased renal glomerulus number  (IAGP)
delayed kidney development  (IAGP)
diaphragmatic hernia  (IAGP)
dilated respiratory conducting tube  (IAGP)
disorganized testis cords  (IAGP)
ectopic ovary  (IAGP)
edema  (IEA)
embryonic growth retardation  (IEA)
enlarged kidney  (IEA)
enlarged testis  (IEA)
fused kidneys  (IAGP)
glomerulosclerosis  (IAGP)
hemopericardium  (IAGP)
hydroureter  (IAGP)
impaired branching involved in alveolar sac morphogenesis  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased circulating calcium level  (IEA)
increased heart right atrium size  (IAGP)
increased tumor incidence  (IAGP)
increased urine protein level  (IAGP)
kidney atrophy  (IAGP)
kidney cyst  (IAGP)
microphthalmia  (IEA)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pale kidney  (IAGP)
pallor  (IAGP)
persistence of hyaloid vascular system  (IEA)
podocyte foot process effacement  (IAGP)
prenatal lethality  (IAGP)
preweaning lethality, complete penetrance  (IEA)
primary sex reversal  (IAGP)
pulmonary hypoplasia  (IAGP)
renal glomerulus atrophy  (IAGP)
renal hypoplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
secondary sex reversal  (IAGP)
sex reversal  (IAGP)
small gonad  (IAGP)
small kidney  (IAGP)
small lung  (IAGP)
small lung lobe  (IAGP)
small spleen  (IEA)
thin myocardium  (IAGP)
ureter hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Bastami M, etal., Genet Test Mol Biomarkers. 2016 May;20(5):241-8. doi: 10.1089/gtmb.2015.0253. Epub 2016 Feb 24.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population. Yang L, etal., Genet Test Mol Biomarkers. 2017 May;21(5):312-315. doi: 10.1089/gtmb.2016.0324. Epub 2017 Mar 27.
10. Association Between TCF21 Gene Polymorphism with the Incidence of Paroxysmal Atrial Fibrillation and the Efficacy of Radiofrequency Ablation for Patients with Paroxysmal Atrial Fibrillation. Zhang X, etal., Int J Gen Med. 2022 May 16;15:4975-4983. doi: 10.2147/IJGM.S366956. eCollection 2022.
Additional References at PubMed
PMID:9507058   PMID:9545521   PMID:9545526   PMID:9733105   PMID:10349636   PMID:10572052   PMID:10615124   PMID:10892744   PMID:10922068   PMID:10944221   PMID:11042159   PMID:11076861  
PMID:11287187   PMID:11591653   PMID:12217315   PMID:12477932   PMID:12493738   PMID:12493912   PMID:12591246   PMID:12619136   PMID:14595844   PMID:15162516   PMID:15289436   PMID:15329346  
PMID:15385444   PMID:15469978   PMID:15472070   PMID:15489334   PMID:15533830   PMID:15919722   PMID:15944191   PMID:16141072   PMID:16141073   PMID:16207825   PMID:16415157   PMID:16452092  
PMID:16511601   PMID:16618389   PMID:16839542   PMID:16844427   PMID:17384148   PMID:17551956   PMID:17652354   PMID:17855428   PMID:17908931   PMID:18159948   PMID:18287559   PMID:18324732  
PMID:18554416   PMID:18557763   PMID:18816853   PMID:18948621   PMID:19060336   PMID:19416211   PMID:19531352   PMID:20059953   PMID:20211142   PMID:20534536   PMID:20881014   PMID:21252157  
PMID:21267068   PMID:21350214   PMID:21429986   PMID:21432986   PMID:21512159   PMID:21664901   PMID:21873635   PMID:22318627   PMID:22511595   PMID:22573622   PMID:22660318   PMID:22687751  
PMID:22711520   PMID:22792366   PMID:22833126   PMID:22988430   PMID:23063127   PMID:23112163   PMID:23160954   PMID:23471215   PMID:24131628   PMID:24135228   PMID:24650916   PMID:24705356  
PMID:24850858   PMID:24904088   PMID:24952961   PMID:24996922   PMID:25139858   PMID:26020946   PMID:26141512   PMID:26390289   PMID:26511275   PMID:26635390   PMID:26670661   PMID:26697723  
PMID:26821812   PMID:27071338   PMID:27084889   PMID:27447449   PMID:27730498   PMID:27820600   PMID:27867037   PMID:27966531   PMID:28172500   PMID:28650345   PMID:28797033   PMID:28891814  
PMID:28959037   PMID:29031500   PMID:29038558   PMID:29158033   PMID:29357412   PMID:29540474   PMID:29664017   PMID:29791840   PMID:30146481   PMID:30153110   PMID:30377232   PMID:30478225  
PMID:30675802   PMID:31125253   PMID:31359001   PMID:31549421   PMID:31558567   PMID:31624071   PMID:31827131   PMID:32212902   PMID:32621799   PMID:32715478   PMID:34148307   PMID:34162856  
PMID:34253819   PMID:34569705   PMID:35084365   PMID:35176223   PMID:35905011   PMID:35919523   PMID:36007455   PMID:36653444   PMID:36805487   PMID:36857185   PMID:36861441   PMID:36997664  
PMID:37115600   PMID:37154157   PMID:37458435   PMID:37524711   PMID:37769108   PMID:37776854   PMID:38197329   PMID:38355793   PMID:38755186   PMID:38972757  


Genomics

Comparative Map Data
Tcf21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391022,693,162 - 22,696,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1022,693,180 - 22,696,073 (-)EnsemblGRCm39 Ensembl
GRCm381022,817,263 - 22,820,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1022,817,281 - 22,820,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv371022,537,069 - 22,539,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361022,506,679 - 22,509,544 (-)NCBIMGSCv36mm8
Celera1023,754,029 - 23,756,913 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map1010.33NCBI
TCF21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386133,889,113 - 133,895,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6133,889,113 - 133,895,553 (+)EnsemblGRCh38hg38GRCh38
GRCh376134,210,251 - 134,216,675 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,251,970 - 134,258,368 (+)NCBINCBI36Build 36hg18NCBI36
Build 346134,251,969 - 134,258,368NCBI
Celera6134,951,327 - 134,957,746 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6131,779,608 - 131,786,028 (+)NCBIHuRef
CHM1_16134,473,121 - 134,479,537 (+)NCBICHM1_1
T2T-CHM13v2.06135,077,847 - 135,084,271 (+)NCBIT2T-CHM13v2.0
Tcf21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,520,499 - 24,523,358 (+)NCBIGRCr8
mRatBN7.2122,701,353 - 22,704,212 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,701,353 - 22,704,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,480,305 - 22,483,164 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0128,480,090 - 28,482,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,677,349 - 22,680,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0123,906,717 - 23,909,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl123,906,717 - 23,909,566 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,370,183 - 25,373,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,211,054 - 23,213,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,214,112 - 23,214,625 (+)NCBI
Celera121,429,543 - 21,432,402 (+)NCBICelera
Cytogenetic Map1p12NCBI
Tcf21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554392,617,492 - 2,620,644 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554392,617,562 - 2,620,613 (-)NCBIChiLan1.0ChiLan1.0
TCF21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25153,862,783 - 153,865,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16151,768,855 - 151,775,684 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06131,656,582 - 131,662,983 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16135,754,896 - 135,761,294 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6135,754,896 - 135,761,294 (+)Ensemblpanpan1.1panPan2
TCF21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,856,281 - 26,859,654 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,856,587 - 26,859,647 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha127,737,867 - 27,741,067 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0127,014,669 - 27,017,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl127,015,081 - 27,017,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1126,898,755 - 26,901,959 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0126,778,392 - 26,781,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0127,087,943 - 27,091,143 (+)NCBIUU_Cfam_GSD_1.0
Tcf21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946121,954,674 - 121,957,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365601,733,903 - 1,736,890 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365601,733,903 - 1,736,895 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl129,975,280 - 29,978,255 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1129,975,280 - 29,978,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2133,477,834 - 33,478,622 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11339,607,179 - 39,610,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1339,607,182 - 39,610,388 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604011,792,052 - 11,795,253 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624942890,365 - 893,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624942890,465 - 893,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcf21
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:140
Interacting mature miRNAs:160
Transcripts:ENSMUST00000049930
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301659Arrd2_mage-related retinal degeneration 2 (mouse)Not determined102028318526890391Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
Tcf21  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381022,819,750 - 22,819,873UniSTSGRCm38
MGSCv371022,539,556 - 22,539,679UniSTSGRCm37
Celera1023,756,535 - 23,756,658UniSTS
Cytogenetic Map10A3UniSTS
cM Map1016.0UniSTS
Spp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E5UniSTS
Cytogenetic Map10A3UniSTS
Tcf21  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A3UniSTS
Tcf21  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000049930   ⟹   ENSMUSP00000053178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1022,693,180 - 22,696,073 (-)Ensembl
GRCm38.p6 Ensembl1022,817,281 - 22,820,174 (-)Ensembl
Ensembl Acc Id: ENSMUST00000218002   ⟹   ENSMUSP00000151767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1022,694,271 - 22,696,058 (-)Ensembl
GRCm38.p6 Ensembl1022,818,372 - 22,820,159 (-)Ensembl
RefSeq Acc Id: NM_011545   ⟹   NP_035675
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391022,693,162 - 22,696,042 (-)NCBI
GRCm381022,817,263 - 22,820,143 (-)NCBI
MGSCv371022,537,069 - 22,539,934 (-)RGD
Celera1023,754,029 - 23,756,913 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035675   ⟸   NM_011545
- UniProtKB: Q3U023 (UniProtKB/Swiss-Prot),   O35437 (UniProtKB/Swiss-Prot),   A0A1W2P7S0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000151767   ⟸   ENSMUST00000218002
Ensembl Acc Id: ENSMUSP00000053178   ⟸   ENSMUST00000049930
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35437-F1-model_v2 AlphaFold O35437 1-179 view protein structure

Promoters
RGD ID:6819998
Promoter ID:MM_KWN:3725
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000049930
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361022,539,396 - 22,539,947 (-)MPROMDB
RGD ID:8671644
Promoter ID:EPDNEW_M13853
Type:multiple initiation site
Name:Tcf21_1
Description:Mus musculus transcription factor 21 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381022,820,143 - 22,820,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202715 AgrOrtholog
Ensembl Genes ENSMUSG00000045680 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049930 ENTREZGENE
  ENSMUST00000049930.9 UniProtKB/Swiss-Prot
  ENSMUST00000218002.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E-box_TF_Regulators UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21412 UniProtKB/Swiss-Prot
MGD MGI:1202715 ENTREZGENE
NCBI Gene 21412 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR 21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcf21 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P7S0 ENTREZGENE, UniProtKB/TrEMBL
  O35437 ENTREZGENE
  Q3U023 ENTREZGENE
  TCF21_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U023 UniProtKB/Swiss-Prot