| 727785 | Smyd2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (ortholog); p53 binding (ortholog); protein-lysine N-methyltransferase activity (ortholog); INVOLVED IN heart development; negative regulation of cell population proliferation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; atrazine | 13 | 103956470 | 103997774 | Rat | 148 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1354091 | SMYD2 | SET and MYND domain containing 2 | SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008] | 1 | 214281159 | 214337131 | Human | 142 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1552013 | Smyd2 | SET and MYND domain containing 2 | Enables RNA polymerase II complex binding activity and histone H3K36 methyltransferase activity. Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Located in cytosol and nucleus. Is expressed in several structures, including gonad; heart; hemolymphoi d system gland; nasal cavity epithelium; and nervous system. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 189612689 | 189654758 | Mouse | 136 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8787129 | Smyd2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (ortholog); p53 binding (ortholog); protein-lysine N-methyltransferase activity (ortholog); INVOLVED IN heart development (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of trans cription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | NW_004955406 | 3467123 | 3509156 | Chinchilla | 30 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11987391 | SMYD2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (inferred); histone H3K4 trimethyltransferase activity (inferred); metal ion binding (inferred); INVOLVED IN heart development (ortholog); peptidyl-lysine dimethylation (ortholog); peptidyl-lysine monomethylation (ortholog); PA RTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | 1 | 189849167 | 189905193 | Bonobo | 41 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12385563 | SMYD2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (inferred); histone H3K4 trimethyltransferase activity (inferred); histone methyltransferase activity (inferred); INVOLVED IN heart development (ortholog); peptidyl-lysine dimethylation (ortholog); peptidyl-lysine monomethylati on (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | 7 | 12281581 | 12331294 | Dog | 46 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12517808 | Smyd2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (inferred); histone H3K4 trimethyltransferase activity (inferred); histone methyltransferase activity (inferred); INVOLVED IN heart development (ortholog); peptidyl-lysine dimethylation (ortholog); peptidyl-lysine monomethylati on (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | NW_004936628 | 3917898 | 3965382 | Squirrel | 43 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18370309 | SMYD2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (inferred); histone H3K4 trimethyltransferase activity (inferred); histone methyltransferase activity (inferred); INVOLVED IN heart development (ortholog); peptidyl-lysine dimethylation (ortholog); peptidyl-lysine monomethylati on (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | | | | Green Monkey | 43 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626070174 | Smyd2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (ortholog); p53 binding (ortholog); protein-lysine N-methyltransferase activity (ortholog); INVOLVED IN heart development (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of trans cription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 30 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155240917 | smyd2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18916611 | Smyd2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (ortholog); p53 binding (ortholog); RNA polymerase II complex binding (ortholog); INVOLVED IN heart development (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of transcription b y RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 41 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13996960 | SMYD2 | SET and MYND domain containing 2 | ENCODES a protein that exhibits histone H3K36 methyltransferase activity (ortholog); protein-lysine N-methyltransferase activity (ortholog); RNA polymerase II complex binding (ortholog); INVOLVED IN heart development (ortholog); negative regulation of cell population proliferation (ortholog); negati ve regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; ASSOCIATED WITH Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | | | | Pig | 57 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155238082 | smyd2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240918 | smyd2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12100596 | LOC100688721 | N-lysine methyltransferase SMYD2-like | | 21 | 4768363 | 4772452 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |