| 621149 | Slc22a4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits quaternary ammonium group transmembrane transporter activity; acetylcholine transmembrane transporter activity (ortholog); amino acid transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake; lactation; liver regeneration; PARTICIPATES IN cispla tin response pathway; ASSOCIATED WITH chronic obstructive pulmonary disease; metabolic dysfunction-associated steatotic liver disease; Coxsackievirus Infections (ortholog); FOUND IN apical plasma membrane; mitochondrion; neuronal cell body; INTERACTS WITH (R)-carnitine; 6-propyl-2-thiouracil; acetamide | 10 | 38634098 | 38687409 | Rat | 244 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733281 | SLC22A4 | solute carrier family 22 member 4 | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membran e protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008] | 5 | 132294394 | 132344190 | Human | 254 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733282 | Slc22a4 | solute carrier family 22 (organic cation transporter), member 4 | Enables carnitine transmembrane transporter activity. Acts upstream of or within carnitine metabolic process; carnitine transport; and triglyceride metabolic process. Located in apical plasma membrane and mitochondrial membrane. Is expressed in several structures, including integumental system; live r; musculoskeletal system; nervous system; and nose. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human SLC22A4 (solute carrier family 22 member 4). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 53873941 | 53920866 | Mouse | 255 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8720045 | Slc22a4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits acetylcholine transmembrane transporter activity (ortholog); amino acid transmembrane transporter activity (ortholog); amino-acid betaine transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); amino acid import across plasma membra ne (ortholog); carnitine metabolic process (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); mitochondrial membrane (ortholog) | NW_004955408 | 3671772 | 3737946 | Chinchilla | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11846871 | SLC22A4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); carnitine metabolic process (ortholog); carnitine transport (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructiv e pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); mitochondrion (ortholog); neuronal cell body (ortholog) | 5 | 127717077 | 127766793 | Bonobo | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12070012 | SLC22A4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits acetylcholine transmembrane transporter activity (ortholog); amino acid transmembrane transporter activity (ortholog); amino-acid betaine transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); amino acid import across plasma membra ne (ortholog); carnitine metabolic process (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); mitochondrial membrane (ortholog) | 11 | 20599281 | 20643893 | Dog | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18368307 | SLC22A4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); carnitine metabolic process (ortholog); carnitine transport (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructiv e pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); mitochondrion (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 283988678 | slc22a4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18922885 | Slc22a4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits acetylcholine transmembrane transporter activity (ortholog); amino acid transmembrane transporter activity (ortholog); amino-acid betaine transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); amino acid import across plasma membra ne (ortholog); carnitine metabolic process (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14029613 | SLC22A4 | solute carrier family 22 member 4 | ENCODES a protein that exhibits quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); carnitine metabolic process (ortholog); carnitine transport (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructiv e pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); mitochondrion (ortholog); neuronal cell body (ortholog) | | | | Pig | 64 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 288083407 | slc22a4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284994431 | slc22a4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12729483 | LOC101975630 | solute carrier family 22 member 4 | ENCODES a protein that exhibits quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN acetylcholine uptake (ortholog); carnitine metabolic process (ortholog); carnitine transport (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH chronic obstructiv e pulmonary disease (ortholog); Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); FOUND IN apical plasma membrane (ortholog); mitochondrion (ortholog); neuronal cell body (ortholog) | NW_004936647 | 2825814 | 2874786 | Squirrel | 59 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 15567362 | Gm50459 | predicted gene, 50459 | | | | | Mouse | | old_gene_name | gene, unprocessed_pseudogene |
| 12391828 | SLC22A5 | solute carrier family 22 member 5 | ENCODES a protein that exhibits (R)-carnitine transmembrane transporter activity (ortholog); carnitine transmembrane transporter activity (ortholog); quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN (R)-carnitine transport (ortholog); adult heart development (orth olog); carnitine metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Cardiac Fibrosis (ortholog); cardiomyopathy (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH penconazole; tebuconazole; triticonazole | 11 | 20659023 | 20686359 | Dog | 104 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |