SLC22A4 (solute carrier family 22 member 4) - Rat Genome Database

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Gene: SLC22A4 (solute carrier family 22 member 4) Pan paniscus
Analyze
Symbol: SLC22A4
Name: solute carrier family 22 member 4
RGD ID: 11846871
Description: ENCODES a protein that exhibits organic cation transmembrane transporter activity (ortholog); quaternary ammonium group transmembrane transporter activity (ortholog); INVOLVED IN carnitine metabolic process (ortholog); carnitine transport (ortholog); quaternary ammonium group transport (ortholog); PARTICIPATES IN cisplatin response pathway; ASSOCIATED WITH Coxsackievirus Infections (ortholog); Enterovirus Infections (ortholog); familial adenomatous polyposis 1 (ortholog); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: solute carrier family 22 (organic cation/ergothioneine transporter), member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,609,074 - 127,662,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,750,856 - 125,801,453 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,717,077 - 127,766,793 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,879,374 - 133,929,439 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,879,387 - 133,929,439 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC22A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,609,074 - 127,662,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,750,856 - 125,801,453 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,717,077 - 127,766,793 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,879,374 - 133,929,439 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,879,387 - 133,929,439 (+)Ensemblpanpan1.1panPan2
SLC22A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,294,394 - 132,344,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,294,394 - 132,344,190 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,630,087 - 131,679,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,658,044 - 131,707,798 (+)NCBINCBI36Build 36hg18NCBI36
Build 345131,658,043 - 131,707,796NCBI
Celera5127,760,255 - 127,809,972 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,822,406 - 126,872,150 (+)NCBIHuRef
CHM1_15131,062,911 - 131,112,639 (+)NCBICHM1_1
T2T-CHM13v2.05132,814,292 - 132,864,084 (+)NCBIT2T-CHM13v2.0
Slc22a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,873,941 - 53,920,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,873,949 - 53,918,916 (-)EnsemblGRCm39 Ensembl
GRCm381153,983,115 - 54,030,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,983,123 - 54,028,090 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,796,628 - 53,841,592 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,826,549 - 53,871,513 (-)NCBIMGSCv36mm8
Celera1158,570,827 - 58,615,496 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.07NCBI
Slc22a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,634,098 - 38,687,409 (-)NCBIGRCr8
mRatBN7.21038,133,333 - 38,179,932 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,133,322 - 38,179,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,818,653 - 42,864,486 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,308,749 - 42,354,587 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,812,450 - 37,858,285 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,334,972 - 39,373,508 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01039,121,490 - 39,154,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1037,476,326 - 37,522,094 (-)NCBICelera
Cytogenetic Map10q22NCBI
Slc22a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,671,772 - 3,737,612 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,671,772 - 3,737,946 (+)NCBIChiLan1.0ChiLan1.0
SLC22A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,599,281 - 20,643,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,401,045 - 19,445,624 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,384,967 - 21,429,553 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11120,103,729 - 20,148,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,951,861 - 19,996,466 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,593,741 - 20,638,332 (+)NCBIUU_Cfam_GSD_1.0
LOC101975630
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,822,961 - 115,872,218 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,825,814 - 2,874,774 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,825,814 - 2,874,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,595,584 - 134,639,777 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,594,843 - 134,641,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,999,122 - 140,061,471 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,123,442 - 35,173,254 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,124,433 - 35,173,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,770,859 - 42,820,375 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,698,456 - 39,808,718 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,740,026 - 39,809,265 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000058730   ⟹   ENSPPAP00000035841
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5133,879,387 - 133,929,439 (+)Ensembl
RefSeq Acc Id: XM_003829313   ⟹   XP_003829361
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24127,609,078 - 127,662,069 (+)NCBI
NHGRI_mPanPan15125,750,856 - 125,801,453 (+)NCBI
Mhudiblu_PPA_v05127,717,077 - 127,766,793 (+)NCBI
PanPan1.15133,879,374 - 133,929,439 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063604220   ⟹   XP_063460290
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24127,609,074 - 127,662,069 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003829361 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460290 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000035841
  ENSPPAP00000035841.1
Reference Protein Sequences
RefSeq Acc Id: XP_003829361   ⟸   XM_003829313
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C4N8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000035841   ⟸   ENSPPAT00000058730
RefSeq Acc Id: XP_063460290   ⟸   XM_063604220
- Peptide Label: isoform X2
Protein Domains
Major facilitator superfamily (MFS) profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058730.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/TrEMBL
  S22A4/5 UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
KEGG Report pps:100994599 UniProtKB/TrEMBL
NCBI Gene SLC22A4 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 4 UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A2R9C4N8 ENTREZGENE, UniProtKB/TrEMBL