| 620159 | Skap2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibe nzodioxine | 4 | 82281221 | 82431664 | Rat | 120 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734438 | Skap2 | src family associated phosphoprotein 2 | Acts upstream of or within negative regulation of cell population proliferation. Located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). [provided by Allianc e of Genome Resources, Jul 2025] | 6 | 51836145 | 51989529 | Mouse | 134 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345057 | SKAP2 | src kinase associated phosphoprotein 2 | The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This prot ein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] | 7 | 26654770 | 26864590 | Human | 122 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8958331 | Skap2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955410 | 28447073 | 28618450 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11844051 | SKAP2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 7 | 27309599 | 27505842 | Bonobo | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12311174 | SKAP2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 14 | 39914285 | 40261782 | Dog | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12474064 | Skap2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936478 | 3393425 | 3566214 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867057 | SKAP2 | src kinase associated phosphoprotein 2 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 18342457 | SKAP2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13910761 | SKAP2 | src kinase associated phosphoprotein 2 | ENCODES a protein that exhibits kinase activity (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246973 | skap2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625990459 | Skap2 | src kinase associated phosphoprotein 2 | INVOLVED IN negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246974 | skap2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246366 | skap2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18917512 | LOC101713038 | src kinase-associated phosphoprotein 2 | ENCODES a protein that exhibits kinase activity (inferred); INVOLVED IN B cell activation (inferred); FOUND IN cytoplasm (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 5 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |