| 69407 | Sik1 | salt-inducible kinase 1 | ENCODES a protein that exhibits protein kinase binding; protein serine/threonine kinase activity; 14-3-3 protein binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of sodium ion transport; ASSOCIATED WITH Cold Injury; develo pmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 20 | 9947104 | 9958729 | Rat | 307 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69451 | SIK1 | salt inducible kinase 1 | This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is as sociated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016] | 21 | 43414483 | 43427131 | Human | 378 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 69452 | Sik1 | salt inducible kinase 1 | Enables several functions, including ATP binding activity; cAMP response element binding protein binding activity; and enzyme binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and regulation of primary metabolic process. Located in cyt oplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 32063222 | 32074808 | Mouse | 300 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8846268 | Sik1 | salt inducible kinase 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP binding (ortholog); cAMP response element binding protein binding (ortholog); INVOLVED IN anoikis (ortholog); cardiac muscle cell differentiation (ortholog); entrainment of circadian clock by photoperiod (ortholog); ASSOCIATED WI TH Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955407 | 38739062 | 38749293 | Chinchilla | 55 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11797538 | SIK1 | salt inducible kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of CREB transcription factor activity (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WIT H Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 21 | 29675040 | 29689408 | Bonobo | 67 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12151278 | SIK1 | salt inducible kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of CREB transcription factor activity (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WIT H Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 31 | 37455130 | 37466829 | Dog | 64 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12648063 | Sik1 | salt inducible kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of CREB transcription factor activity (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WIT H Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | NW_004936500 | 774749 | 784326 | Squirrel | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625884450 | Sik1 | salt inducible kinase 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP binding (ortholog); cAMP response element binding protein binding (ortholog); INVOLVED IN anoikis (ortholog); cardiac muscle cell differentiation (ortholog); entrainment of circadian clock by photoperiod (ortholog); ASSOCIATED WI TH Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 55 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 598276998 | sik1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18787701 | SIK1 | salt inducible kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of CREB transcription factor activity (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WIT H Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13888208 | SIK1 | salt inducible kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of CREB transcription factor activity (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WIT H Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Pig | 64 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18935523 | Sik1 | salt inducible kinase 1 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); cAMP response element binding protein binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN anoikis (ortholog); cardiac muscle cell differentiation (ortholog); entrainment of circadian clock by photoperiod (ortholog ); ASSOCIATED WITH Cold Injury (ortholog); developmental and epileptic encephalopathy 30 (ortholog); Developmental Disabilities (ortholog); FOUND IN nucleus (ortholog) | | | | Naked Mole-Rat | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13440503 | SIK1B | salt inducible kinase 1B (putative) | ENCODES a protein that exhibits 14-3-3 protein binding; ATP binding; magnesium ion binding; INVOLVED IN intracellular signal transduction; positive regulation of anoikis; protein autophosphorylation; ASSOCIATED WITH benign epilepsy with centrotemporal spikes; FOUND IN cytoplasm; nucleus | 21 | 6111131 | 6123778 | Human | 72 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |