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Gene: SIK1 (salt inducible kinase 1) Homo sapiens
Symbol: SIK1
Name: salt inducible kinase 1
Description: Exhibits several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Involved in intracellular signal transduction; positive regulation of anoikis; and protein autophosphorylation. Localizes to cytoplasm and nucleus. Implicated in early infantile epileptic encephalopathy 30.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EIEE30; MSK; myocardial SNF1-like kinase; Probable serine/threonine-protein kinase SIK1B; salt-inducible kinase 1; Salt-inducible kinase 1B; salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SIK1; serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK; SIK; SIK-1; SIK1B; SNF1-like kinase; SNF1LK
Mus musculus (house mouse) : Sik1 (salt inducible kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sik1 (salt-inducible kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sik1 (salt inducible kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIK1 (salt inducible kinase 1)
Canis lupus familiaris (dog) : SIK1 (salt inducible kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sik1 (salt inducible kinase 1)
Sus scrofa (pig) : SIK1 (salt inducible kinase 1)
Chlorocebus sabaeus (African green monkey) : SIK1 (salt inducible kinase 1)
Heterocephalus glaber (naked mole-rat) : Sik1 (salt inducible kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2143,414,483 - 43,427,131 (-)EnsemblGRCh38hg38GRCh38
GRCh382143,414,483 - 43,427,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372144,834,395 - 44,847,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,658,823 - 43,671,430 (-)NCBINCBI36hg18NCBI36
Build 342143,658,826 - 43,671,436NCBI
Celera2129,940,650 - 29,953,256 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2130,202,979 - 30,223,345 (-)NCBIHuRef
CHM1_12144,394,974 - 44,407,557 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69451
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.