| 1359661 | Shisa5 | shisa family member 5 | ENCODES a protein that exhibits molecular condensate scaffold activity (ortholog); WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); posit ive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN p53 signaling pathway; FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide | 8 | 118569975 | 118584880 | Rat | 100 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1602716 | SHISA5 | shisa family member 5 | This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016] | 3 | 48467876 | 48504810 | Human | 97 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1619194 | Shisa5 | shisa family member 5 | Predicted to enable WW domain binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in endoplasmic reticulum and nuclear envelope. Is expressed in blood vessel; cortical plate; extraembryonic component; foregut div erticulum; and meninges. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 108867635 | 108886860 | Mouse | 101 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8961638 | Shisa5 | shisa family member 5 | ENCODES a protein that exhibits molecular condensate scaffold activity (ortholog); WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); posit ive regulation of canonical NF-kappaB signal transduction (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | NW_004955532 | 535992 | 544542 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11830901 | SHISA5 | shisa family member 5 | ENCODES a protein that exhibits WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transd uction (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | 3 | 48389924 | 48426064 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12274580 | SHISA5 | shisa family member 5 | ENCODES a protein that exhibits WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transd uction (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | 20 | 40604183 | 40624607 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12686790 | Shisa5 | shisa family member 5 | ENCODES a protein that exhibits WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transd uction (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | NW_004936529 | 266671 | 292103 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916077 | Shisa5 | shisa family member 5 | ENCODES a protein that exhibits molecular condensate scaffold activity (ortholog); WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); posit ive regulation of canonical NF-kappaB signal transduction (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626128510 | Shisa5 | shisa family member 5 | ENCODES a protein that exhibits molecular condensate scaffold activity (ortholog); WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); posit ive regulation of canonical NF-kappaB signal transduction (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18578626 | SHISA5 | shisa family member 5 | ENCODES a protein that exhibits WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transd uction (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14162428 | SHISA5 | shisa family member 5 | ENCODES a protein that exhibits WW domain binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transd uction (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867183 | SHISA5 | shisa family member 5 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 25824874 | SHISA5P1 | SHISA5 pseudogene 1 | | X | 41321413 | 41323574 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095991 | SHISA5P2 | SHISA5 pseudogene 2 | | X | 74065736 | 74067455 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |