| 727829 | Sgpp1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ER to Golgi ceramide transport (ortholog); extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); PARTICIPATES IN sphingosine 1-phosphate signaling pathwa y; sphingolipid metabolic pathway; FOUND IN endoplasmic reticulum (ortholog); membrane (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 6 | 100161024 | 100182214 | Rat | 140 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1343984 | SGPP1 | sphingosine-1-phosphate phosphatase 1 | Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009] | 14 | 63684216 | 63728065 | Human | 134 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1552921 | Sgpp1 | sphingosine-1-phosphate phosphatase 1 | Enables sphingosine-1-phosphate phosphatase activity. Involved in regulation of keratinocyte differentiation. Acts upstream of or within apoptotic signaling pathway and sphingolipid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including adrena l gland; alimentary system; heart; liver; and urinary system. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 75761022 | 75782503 | Mouse | 146 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8941054 | Sgpp1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ER to Golgi ceramide transport (ortholog); extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); PARTICIPATES IN sphingosine 1-phosphate signaling pathwa y; FOUND IN endoplasmic reticulum (ortholog); membrane (ortholog); nucleoplasm (ortholog) | NW_004955466 | 6075507 | 6103739 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11836083 | SGPP1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ER to Golgi ceramide transport (ortholog); extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); PARTICIPATES IN sphingosine 1-phosphate signaling pathwa y; FOUND IN endoplasmic reticulum (ortholog); membrane (ortholog); nucleoplasm (ortholog) | 14 | 44265017 | 44308897 | Bonobo | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12145642 | SGPP1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits hydrolase activity (inferred); sphingosine-1-phosphate phosphatase activity (inferred); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); sphinganine-1-phosphate metabolic process (ortholog); PARTICIPATES I N sphingosine 1-phosphate signaling pathway; FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 8 | 38195649 | 38228299 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12637420 | Sgpp1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits hydrolase activity (inferred); sphingosine-1-phosphate phosphatase activity (inferred); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); sphinganine-1-phosphate metabolic process (ortholog); PARTICIPATES I N sphingosine 1-phosphate signaling pathway; FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | NW_004936495 | 7500991 | 7528520 | Squirrel | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908285 | Sgpp1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits hydrolase activity (inferred); sphingosine-1-phosphate phosphatase activity (inferred); INVOLVED IN ER to Golgi ceramide transport (ortholog); extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); PARTICIPATES IN sphingosi ne 1-phosphate signaling pathway; FOUND IN endoplasmic reticulum (ortholog); membrane (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14065958 | SGPP1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits hydrolase activity (inferred); sphingosine-1-phosphate phosphatase activity (inferred); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); sphinganine-1-phosphate metabolic process (ortholog); PARTICIPATES I N sphingosine 1-phosphate signaling pathway; FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405859528 | sgpp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625890318 | Sgpp1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ER to Golgi ceramide transport (ortholog); extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); PARTICIPATES IN sphingosine 1-phosphate signaling pathwa y; FOUND IN endoplasmic reticulum (ortholog); membrane (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598151598 | sgpp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18360440 | SGPP1 | sphingosine-1-phosphate phosphatase 1 | ENCODES a protein that exhibits hydrolase activity (inferred); sphingosine-1-phosphate phosphatase activity (inferred); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); intrinsic apoptotic signaling pathway (ortholog); sphinganine-1-phosphate metabolic process (ortholog); PARTICIPATES I N sphingosine 1-phosphate signaling pathway; FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405858563 | sgpp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858564 | sgpp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626173062 | sgpp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864610 | sgpp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858953 | sgpp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626187360 | sgpp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859527 | sgpp1.L | | | | | | African Clawed Frog | | symbol | gene, null |