| 621497 | Sdcbp | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding; ephrin receptor binding; growth factor binding; INVOLVED IN presynapse assembly; negative regulation of receptor internalization (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN interleuk in-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN presynapse; cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione | 5 | 24245279 | 24314712 | Rat | 197 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733371 | Sdcbp | syndecan binding protein | Enables interleukin-5 receptor binding activity. Involved in positive regulation of cell growth; positive regulation of cell migration; and positive regulation of cell population proliferation. Acts upstream of or within Ras protein signal transduction. Part of interleukin-5 receptor complex. Is exp ressed in several structures, including central nervous system; heart; nose; skin; and urinary system. Orthologous to human SDCBP (syndecan binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 6365713 | 6396120 | Mouse | 225 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343667 | SDCBP | syndecan binding protein | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also aff ect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017] | 8 | 58553261 | 58582858 | Human | 225 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8894331 | Sdcbp | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); frizzled binding (ortholog); INVOLVED IN negative regulation of receptor internalization (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulatio n of cell growth (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular exosome (ortholog) | NW_004955454 | 17093930 | 17113491 | Chinchilla | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11982257 | SDCBP | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN presynapse assembly (ortholog); Ras protein signal transduction (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN presynapse (ortholog) | 8 | 54992627 | 55022560 | Bonobo | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12067089 | SDCBP | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); frizzled binding (ortholog); INVOLVED IN negative regulation of receptor internalization (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulatio n of cell growth (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN cytosol (ortholog); extracellular exosome (ortholog); interleukin-5 receptor complex (ortholog); INTERACTS WITH mocetinostat | 29 | 9331876 | 9370489 | Dog | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12615362 | Sdcbp | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN presynapse assembly (ortholog); Ras protein signal transduction (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN presynapse (ortholog) | NW_004936496 | 14331971 | 14347123 | Squirrel | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14128587 | SDCBP | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN presynapse assembly (ortholog); Ras protein signal transduction (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN presynapse (ortholog) | | | | Pig | 77 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18586705 | SDCBP | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); frizzled binding (ortholog); INVOLVED IN negative regulation of receptor internalization (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulatio n of cell growth (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN cytosol (ortholog); extracellular exosome (ortholog); interleukin-5 receptor complex (ortholog) | | | | Green Monkey | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922534 | Sdcbp | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); frizzled binding (ortholog); INVOLVED IN negative regulation of receptor internalization (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulatio n of cell growth (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN cytosol (ortholog); extracellular exosome (ortholog); interleukin-5 receptor complex (ortholog) | | | | Naked Mole-Rat | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259423 | sdcbp | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626131800 | Sdcbp | syndecan binding protein | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ephrin receptor binding (ortholog); frizzled binding (ortholog); INVOLVED IN negative regulation of receptor internalization (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulatio n of cell growth (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; syndecan signaling pathway; ASSOCIATED WITH osteoarthritis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular exosome (ortholog) | | | | Black Rat | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259811 | sdcbp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253260 | sdcbp.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1307709 | Sdcbp2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell population proliferation (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (orth olog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 160521309 | 160558452 | Rat | 127 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317056 | SDCBP2 | syndecan binding protein 2 | The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protei n binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011] | 20 | 1309909 | 1329139 | Human | 131 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317057 | Sdcbp2 | syndecan binding protein (syntenin) 2 | Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in cell population proliferation. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be a ctive in cytoplasm and plasma membrane. Is expressed in embryo and pancreas epithelium. Orthologous to human SDCBP2 (syndecan binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 151414203 | 151431925 | Mouse | 136 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8721846 | Sdcbp2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell population proliferation (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (orth olog) | NW_004955596 | 531741 | 555710 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11761889 | SDCBP2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); INVOLVED IN cell population proliferation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | 20 | 1464953 | 1484201 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12392221 | SDCBP2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); INVOLVED IN cell population proliferation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | 24 | 19679580 | 19696015 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12630848 | Sdcbp2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); INVOLVED IN cell population proliferation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | NW_004936485 | 17336209 | 17356896 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14251778 | SDCBP2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); INVOLVED IN cell population proliferation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 28 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18579376 | SDCBP2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); INVOLVED IN cell population proliferation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908142 | Sdcbp2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell population proliferation (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog); nucleolus (orth olog) | | | | Naked Mole-Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626117302 | Sdcbp2 | syndecan binding protein 2 | ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell population proliferation (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (orth olog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626174150 | sdcbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626174221 | sdcbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626180181 | sdcbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626185705 | sdcbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 7175589 | SDCBPP1 | syndecan binding protein pseudogene 1 | | 10 | 6292906 | 6294740 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7175684 | SDCBPP2 | syndecan binding protein pseudogene 2 | | 8 | 69942809 | 69944286 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7175935 | SDCBPP3 | syndecan binding protein pseudogene 3 | | X | 40890519 | 40891594 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10399286 | SDCBP2P1 | syndecan binding protein 2 pseudogene 1 | INTERACTS WITH cadmium dichloride | 6 | 73322837 | 73323450 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6893194 | SDCBP2-AS1 | SDCBP2 antisense RNA 1 | INTERACTS WITH aflatoxin B1; cadmium dichloride; DDE | 20 | 1325343 | 1378735 | Human | 14 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5133080 | FKBP1A-SDCBP2 | FKBP1A-SDCBP2 readthrough (NMD candidate) | This locus represents naturally occurring read-through transcription between the neighboring FK506 binding protein 1A, 12kDa and syndecan binding protein (syntenin) 2 genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Dec 2010] | 20 | 1309909 | 1393172 | Human | 2 | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1550274 | Trappc4 | trafficking protein particle complex 4 | Involved in dendrite development. Located in Golgi stack; dendrite; and synaptic vesicle. Part of TRAPP complex. Is active in postsynaptic density membrane and presynaptic active zone. Is expressed in central nervous system; ganglia; olfactory epithelium; thymus primordium; and tooth. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 44315057 | 44318629 | Mouse | 105 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |