| 621657 | Scn3b | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); transmembrane transporter binding (ortholog); voltage-gated sodium channel activity involved in cardiac muscle cell action potential (ortholog); INVOLVED IN nervous system development; sodium ion transport; atrial cardiac muscle cell action potential (ortholog); ASSOCIATED WITH brain edema (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog); Z disc (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 8 | 49527529 | 49550019 | Rat | 175 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1332251 | Scn3b | sodium channel, voltage-gated, type III, beta | Enables transmembrane transporter binding activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in SA node cell action potential; positive regulation of heart rate; and regulation of atrial cardiac muscle cell membrane depolarization. Acts upst ream of or within cardiac conduction and ventricular cardiac muscle cell action potential. Located in Z disc. Is expressed in several structures, including gut; nervous system; sensory organ; skeletal musculature; and urinary system. Used to study Brugada syndrome 7. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 40180512 | 40202914 | Mouse | 184 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1350710 | SCN3B | sodium voltage-gated channel beta subunit 3 | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel be ta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] | 11 | 123629188 | 123654624 | Human | 223 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8970537 | Scn3b | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); transmembrane transporter binding (ortholog); voltage-gated sodium channel activity involved in cardiac muscle cell action potential (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); cardiac c onduction (ortholog); cardiac muscle cell action potential involved in contraction (ortholog); ASSOCIATED WITH brain edema (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog); Z disc (ortholog) | NW_004955412 | 24391764 | 24412912 | Chinchilla | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11835089 | SCN3B | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel activity (inferred); sodium channel inhibitor activity (inferred); sodium channel regulator activity (inferred); INVOLVED IN cardiac conduction (ortholog); nervous system development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH brain ede ma (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN monoatomic ion channel complex (inferred); plasma membrane (inferred); voltage-gated sodium channel complex (inferred) | 11 | 118460860 | 118486563 | Bonobo | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12417891 | SCN3B | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel activity (inferred); sodium channel regulator activity (inferred); transmembrane transporter binding (inferred); INVOLVED IN cardiac conduction (ortholog); nervous system development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH brain ede ma (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN monoatomic ion channel complex (inferred); plasma membrane (inferred); voltage-gated sodium channel complex (inferred) | 5 | 10783235 | 10808342 | Dog | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12607920 | Scn3b | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel activity (inferred); sodium channel inhibitor activity (inferred); sodium channel regulator activity (inferred); INVOLVED IN cardiac conduction (ortholog); nervous system development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH brain ede ma (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN monoatomic ion channel complex (inferred); plasma membrane (inferred); voltage-gated sodium channel complex (inferred) | NW_004936542 | 8082487 | 8106154 | Squirrel | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931521 | Scn3b | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel activity (inferred); sodium channel inhibitor activity (inferred); sodium channel regulator activity (inferred); INVOLVED IN cardiac conduction (ortholog); nervous system development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH brain ede ma (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN monoatomic ion channel complex (inferred); plasma membrane (inferred); voltage-gated sodium channel complex (inferred) | | | | Naked Mole-Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14199809 | SCN3B | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel activity (inferred); sodium channel regulator activity (inferred); transmembrane transporter binding (inferred); INVOLVED IN cardiac conduction (ortholog); nervous system development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH brain ede ma (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN monoatomic ion channel complex (inferred); plasma membrane (inferred); voltage-gated sodium channel complex (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626062937 | Scn3b | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel regulator activity (ortholog); transmembrane transporter binding (ortholog); voltage-gated sodium channel activity involved in cardiac muscle cell action potential (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); cardiac c onduction (ortholog); cardiac muscle cell action potential involved in contraction (ortholog); ASSOCIATED WITH brain edema (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog); Z disc (ortholog) | | | | Black Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249617 | scn3b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18349538 | SCN3B | sodium voltage-gated channel beta subunit 3 | ENCODES a protein that exhibits sodium channel activity (inferred); sodium channel inhibitor activity (inferred); sodium channel regulator activity (inferred); INVOLVED IN cardiac conduction (ortholog); nervous system development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH brain ede ma (ortholog); Brugada syndrome (ortholog); Brugada syndrome 7 (ortholog); FOUND IN monoatomic ion channel complex (inferred); plasma membrane (inferred); voltage-gated sodium channel complex (inferred) | | | | Green Monkey | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242015 | scn3b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249037 | scn3b.S | | | | | | African Clawed Frog | | symbol | gene, null |