| 1343598 | SCLY | selenocysteine lyase | Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008] | 2 | 238061001 | 238099413 | Human | 106 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359514 | Scly | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding; protein homodimerization activity; selenocysteine lyase activity; INVOLVED IN selenocysteine catabolic process; lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); PARTICIPATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex; Golgi apparatus (ortholog); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 99337796 | 99358487 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1552754 | Scly | selenocysteine lyase | Predicted to enable several functions, including protein homodimerization activity; selenocysteine lyase activity; and vitamin B6 binding activity. Acts upstream of or within several processes, including negative regulation of cellular response to oxidative stress; response to insulin; and selenium compound metabolic process. Predicted to be located in Golgi apparatus. Predicted to be part of catalytic complex. Is expressed in alimentary system; liver; and nervous system. Orthologous to human SCLY (selenocysteine lyase). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 91226017 | 91248797 | Mouse | 104 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8836577 | Scly | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); selenocysteine lyase activity (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholo g); PARTICIPATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog); Golgi apparatus (ortholog) | NW_004955542 | 2453826 | 2472951 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12003135 | SCLY | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); vitamin B6 binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholog); PARTICI PATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog) | 2B | 125276540 | 125331057 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12170907 | SCLY | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); vitamin B6 binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholog); PARTICI PATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog) | 25 | 48574648 | 48608367 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12651046 | Scly | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); vitamin B6 binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholog); PARTICI PATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog) | NW_004936525 | 381188 | 407544 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626021363 | Scly | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); selenocysteine lyase activity (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholo g); PARTICIPATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908476 | Scly | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); vitamin B6 binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholog); PARTICI PATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18626687 | SCLY | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); vitamin B6 binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholog); PARTICI PATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14115425 | SCLY | selenocysteine lyase | ENCODES a protein that exhibits amino acid binding (ortholog); protein homodimerization activity (ortholog); vitamin B6 binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of cellular response to oxidative stress (ortholog); response to insulin (ortholog); PARTICI PATES IN selenoamino acid metabolic pathway; FOUND IN catalytic complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251457 | scly | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155251458 | scly.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 2323231 | Scly-ps1 | selenocysteine lyase, pseudogene 1 | | 1 | 172274080 | 172277080 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7243433 | UBE2F-SCLY | UBE2F-SCLY readthrough (NMD candidate) | This locus represents naturally occurring read-through transcription between the neighboring UBE2F (ubiquitin-conjugating enzyme E2F) and SCLY (selenocysteine lyase) genes on chromosome 2. The read-through transcript is a candidate for non-sense mediated mRNA de cay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Feb 2011] | 2 | 237966945 | 238099413 | Human | 7 | symbol , COSMIC , name , description , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |