Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of SCLY mRNA | CTD | PMID:23649840 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SCLY mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | multiple interactions | ISO | Scly (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of SCLY mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Scly (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SCLY mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of SCLY mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31826744 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Scly (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SCLY mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SCLY mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SCLY mRNA | CTD | PMID:21724226 and PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SCLY mRNA | CTD | PMID:20106945 and PMID:21632981 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Scly (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of SCLY mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Scly (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of SCLY promoter | CTD | PMID:26251327 | 3H-1,2-dithiole-3-thione | increases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in increased expression of SCLY mRNA | CTD | PMID:19162173 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of SCLY mRNA | CTD | PMID:21346803 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | Decitabine inhibits the reaction [Smoke results in decreased expression of SCLY mRNA] | CTD | PMID:21095227 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SCLY mRNA | CTD | PMID:24780913 and PMID:25825206 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of SCLY mRNA | CTD | PMID:28959563 | all-trans-retinoic acid | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SCLY mRNA | CTD | PMID:23724009 and PMID:33167477 | antirheumatic drug | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SCLY mRNA | CTD | PMID:24449571 | arsenous acid | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SCLY protein] | CTD | PMID:26598702 | bis(2-chloroethyl) sulfide | increases expression | ISO | Scly (Mus musculus) | 6480464 | Mustard Gas results in increased expression of SCLY mRNA | CTD | PMID:15674844 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SCLY mRNA | CTD | PMID:26982218 more ... | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SCLY mRNA | CTD | PMID:32145629 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SCLY mRNA | CTD | PMID:25181051 | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of SCLY mRNA | CTD | PMID:24136188 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of SCLY mRNA | CTD | PMID:25993096 | choline | multiple interactions | ISO | Scly (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCLY mRNA | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SCLY mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of SCLY mRNA | CTD | PMID:19320972 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SCLY mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SCLY mRNA | CTD | PMID:22465980 | cyclosporin A | increases expression | ISO | SCLY (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SCLY mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SCLY mRNA | CTD | PMID:25562108 | diarsenic trioxide | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SCLY protein] | CTD | PMID:26598702 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SCLY mRNA | CTD | PMID:21266533 | dibutyl phthalate | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SCLY protein | CTD | PMID:30218697 | enzyme inhibitor | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SCLY protein | CTD | PMID:23301498 | ethyl methanesulfonate | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of SCLY mRNA | CTD | PMID:23649840 | fenofibrate | affects expression | EXP | | 6480464 | Fenofibrate affects the expression of SCLY mRNA | CTD | PMID:20801182 | fenthion | increases expression | ISO | Scly (Mus musculus) | 6480464 | Fenthion results in increased expression of SCLY mRNA | CTD | PMID:34813904 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of SCLY mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Scly (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCLY mRNA more ... | CTD | PMID:20938992 and PMID:22206623 | formaldehyde | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SCLY mRNA | CTD | PMID:23649840 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SCLY mRNA | CTD | PMID:33387578 | hydrazine | increases expression | ISO | Scly (Mus musculus) | 6480464 | hydrazine results in increased expression of SCLY mRNA | CTD | PMID:15282401 | hydrogen peroxide | affects expression | ISO | SCLY (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of SCLY mRNA | CTD | PMID:20044591 | L-methionine | multiple interactions | ISO | Scly (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCLY mRNA | CTD | PMID:20938992 | methidathion | increases expression | ISO | Scly (Mus musculus) | 6480464 | methidathion results in increased expression of SCLY mRNA | CTD | PMID:34813904 | N-nitrosomorpholine | decreases expression | EXP | | 6480464 | N-nitrosomorpholine results in decreased expression of SCLY protein | CTD | PMID:19716841 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of SCLY mRNA | CTD | PMID:22110744 | paracetamol | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SCLY mRNA | CTD | PMID:21420995 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SCLY mRNA | CTD | PMID:33387578 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of SCLY mRNA | CTD | PMID:19162173 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SCLY protein | CTD | PMID:30218697 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of SCLY mRNA | CTD | PMID:19162173 | potassium chromate | multiple interactions | ISO | SCLY (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SCLY mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SCLY mRNA | CTD | PMID:22079256 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of SCLY mRNA | CTD | PMID:19162173 | propiconazole | decreases expression | ISO | Scly (Mus musculus) | 6480464 | propiconazole results in decreased expression of SCLY mRNA | CTD | PMID:21278054 | silicon dioxide | increases expression | ISO | Scly (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of SCLY mRNA | CTD | PMID:29203145 | sodium arsenate | decreases expression | ISO | Scly (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of SCLY mRNA | CTD | PMID:20667999 | sodium arsenate | affects methylation | ISO | Scly (Mus musculus) | 6480464 | sodium arsenate affects the methylation of SCLY promoter | CTD | PMID:20667999 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SCLY protein | CTD | PMID:29459688 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SCLY mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SCLY mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Scly (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SCLY mRNA | CTD | PMID:23557971 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SCLY mRNA | CTD | PMID:33387578 | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of SCLY mRNA | CTD | PMID:30589522 | triptonide | decreases expression | ISO | Scly (Mus musculus) | 6480464 | triptonide results in decreased expression of SCLY mRNA | CTD | PMID:33045310 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of SCLY protein | CTD | PMID:21315101 | trovafloxacin | decreases expression | ISO | Scly (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SCLY mRNA | CTD | PMID:35537566 | valproic acid | affects expression | ISO | Scly (Mus musculus) | 6480464 | Valproic Acid affects the expression of SCLY mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | SCLY (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SCLY mRNA | CTD | PMID:23179753 | valproic acid | increases methylation | ISO | SCLY (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SCLY gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | SCLY (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SCLY mRNA | CTD | PMID:25979313 | vincristine | decreases expression | ISO | SCLY (Homo sapiens) | 6480464 | Vincristine results in decreased expression of SCLY mRNA | CTD | PMID:23649840 | |