| 1565558 | Rspo1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); heparin binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN negative regulation of eating behavior; response to insulin; male meiotic nuclear division (ortholog); PARTICIPATES IN Wnt signaling, canonica l pathway; ASSOCIATED WITH obesity; type 1 diabetes mellitus; genetic disease (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 5 | 142536162 | 142557611 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1603515 | RSPO1 | R-spondin 1 | This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, t he protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] | 1 | 37611350 | 37634892 | Human | 143 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1615739 | Rspo1 | R-spondin 1 | Enables heparin binding activity and signaling receptor binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulat ion of male germ cell proliferation. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; genitourinary system; and integumental system. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 124880197 | 124902895 | Mouse | 147 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8898080 | Rspo1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); heparin binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of canonical Wnt signaling pa thway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog) | NW_004955452 | 15415417 | 15435616 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11845406 | RSPO1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of non-canonical Wnt signalin g pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog) | 1 | 36885176 | 36907821 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12295760 | RSPO1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of non-canonical Wnt signalin g pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH bisphenol A | 15 | 4857887 | 4876077 | Dog | 42 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12570152 | Rspo1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of non-canonical Wnt signalin g pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog) | NW_004936474 | 19826808 | 19846453 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932404 | Rspo1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of non-canonical Wnt signalin g pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626125129 | Rspo1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); heparin binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of canonical Wnt signaling pa thway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog) | | | | Black Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18494543 | RSPO1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of non-canonical Wnt signalin g pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14178919 | RSPO1 | R-spondin 1 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); negative regulation of eating behavior (ortholog); positive regulation of non-canonical Wnt signalin g pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284049764 | rspo1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 284048486 | rspo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329328974 | rspo1.S | | | | | | African Clawed Frog | | symbol | gene, null |