| 620167 | Robo2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity; identical protein binding (ortholog); INVOLVED IN axon guidance; spinal cord development; aorta development (ortholog); ASSOCIATED WITH Brain Injuries; transient cerebral ischemia; autistic disorder (ortholog); FOUND IN axolemma (ortho log); cell surface (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 11 | 26015919 | 27583750 | Rat | 163 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736256 | ROBO2 | roundabout guidance receptor 2 | The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 3 | 75906675 | 77649964 | Human | 215 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736257 | Robo2 | roundabout guidance receptor 2 | Predicted to enable axon guidance receptor activity and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway. Acts upstream of or within axon guidance and metanephros develo pment. Located in axolemma. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including autopod; central nervous system; embryo mesenchyme; jaw; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 73688725 | 75244331 | Mouse | 230 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9024646 | Robo2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | NW_004955407 | 14301689 | 15549561 | Chinchilla | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11924934 | ROBO2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | 3 | 76013780 | 77764156 | Bonobo | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12133108 | ROBO2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | 31 | 9415390 | 11047710 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12504251 | Robo2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | NW_004936505 | 5544011 | 6747417 | Squirrel | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288057112 | robo2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14109491 | ROBO2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14387178 | robo2 | | | | | | Fly | | symbol | gene, null |
| 18908018 | Robo2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866168 | ROBO2 | roundabout guidance receptor 2 | INVOLVED IN nervous system development (inferred); FOUND IN membrane (inferred) | | | | Green Monkey | 2 | symbol | gene, protein-coding |
| 18379256 | ROBO2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626034835 | Robo2 | roundabout guidance receptor 2 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); bicusp id aortic valve disease (ortholog); Brain Injuries (ortholog); FOUND IN axolemma (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405865163 | robo2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857626 | robo2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863436 | robo2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626467913 | robo2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864990 | robo2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288057110 | robo2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16572650 | AC133040.1 | novel transcript, antisense to ROBO2 | | | | | Human | | name | gene, lncrna |
| 10399685 | ROBO2P1 | roundabout guidance receptor 2 pseudogene 1 | | 7 | 51600296 | 51600572 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |