| 1347950 | RNF168 | ring finger protein 168 | This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this ge ne result in Riddle syndrome. [provided by RefSeq, Sep 2011] | 3 | 196468783 | 196503768 | Human | 185 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1585168 | Rnf168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2AK15 ubiquitin ligase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide | 11 | 81991352 | 82013306 | Rat | 137 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1623959 | Rnf168 | ring finger protein 168 | Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; histone H2AK15 ubiquitin ligase activity; and ubiquitin binding activity. Involved in isotype switching. Acts upstream of or within cellular response to UV and regulation of pro tein localization. Part of DNA repair complex. Is expressed in central nervous system and genitourinary system. Used to study RIDDLE syndrome. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 32096279 | 32120260 | Mouse | 200 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9060796 | Rnf168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2AK15 ubiquitin ligase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | NW_004955420 | 12656815 | 12676836 | Chinchilla | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11935610 | RNF168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2AK15 ubiquitin ligase activity (inferred); INVOLVED IN cellular response to UV (ortholog); isotype switching (ortholog); regulation of protein localization (ortholog); PARTICIPATES IN ataxia telangiec tasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); site of double-strand break (ortholog) | 3 | 193814785 | 193848620 | Bonobo | 74 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12198321 | RNF168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2AK15 ubiquitin ligase activity (inferred); INVOLVED IN cellular response to UV (ortholog); isotype switching (ortholog); regulation of protein localization (ortholog); PARTICIPATES IN ataxia telangiec tasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog) | 33 | 29542209 | 29575127 | Dog | 74 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12524821 | Rnf168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2AK15 ubiquitin ligase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | NW_004936784 | 1073236 | 1094575 | Squirrel | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155240019 | rnf168 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18936339 | Rnf168 | ring finger protein 168 | ENCODES a protein that exhibits histone H2AK15 ubiquitin ligase activity (ortholog); histone ubiquitin ligase activity (ortholog); K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA repair-dependent chromatin remodeling (or tholog); double-strand break repair via classical nonhomologous end joining (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 64 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14243562 | RNF168 | ring finger protein 168 | ENCODES a protein that exhibits histone H2AK15 ubiquitin ligase activity (ortholog); histone ubiquitin ligase activity (ortholog); K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA repair-dependent chromatin remodeling (or tholog); double-strand break repair via classical nonhomologous end joining (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Pig | 64 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626157867 | Rnf168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H2AK15 ubiquitin ligase activity (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18780060 | RNF168 | ring finger protein 168 | ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); histone H2AK15 ubiquitin ligase activity (inferred); INVOLVED IN cellular response to UV (ortholog); isotype switching (ortholog); regulation of protein localization (ortholog); PARTICIPATES IN ataxia telangiec tasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN DNA repair complex (ortholog); site of double-strand break (ortholog) | | | | Green Monkey | 75 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155240020 | rnf168.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248784 | rnf168.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 13847048 | LOC102167889 | E3 ubiquitin-protein ligase RNF168 | | | | | Pig | | name | gene, protein-coding, MODEL [RefSeq] |
| 16566664 | AC117490.2 | novel transcript, antisense to RNF168 | | | | | Human | | name | gene, lncrna |
| 12531251 | LOC101968528 | E3 ubiquitin-protein ligase RNF168-like | | NW_004936500 | 12696366 | 12697830 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12603728 | LOC101978231 | E3 ubiquitin-protein ligase RNF168-like | | NW_004936624 | 837806 | 840533 | Squirrel | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 7505527 | LOC102557137 | E3 ubiquitin-protein ligase RNF168-like | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN DNA damage response (inferred); FOUND IN nucleus (inferred) | X | 43912623 | 43919557 | Rat | 11 | name | gene, protein-coding, MODEL [RefSeq] |
| 625834078 | LOC116887832 | E3 ubiquitin-protein ligase RNF168-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 16553133 | AC117490.1 | ring finger protein 168 (RNF168) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16558467 | AC133963.2 | ring finger protein 168 (RNF168) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 13948865 | LOC110256674 | E3 ubiquitin-protein ligase RNF168 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |