| 61823 | Rnase4 | ribonuclease A family member 4 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular region (ortholog); extr acellular space (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 15 | 26786287 | 26803634 | Rat | 207 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62114 | Rnase4 | ribonuclease, RNase A family 4 | This gene encodes a member of the pancreatic ribonuclease A superfamily. The encoded enzyme is sereted and has unique uridine specificity. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the angiogenin, ribonuclease, RNase A family, 5 gene. Each gen e splices to a unique downstream exon that contains its complete coding region. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. [provided by RefSeq, Jun 2009] | 14 | 51328534 | 51343608 | Mouse | 203 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 736007 | RNASE4 | ribonuclease A family member 4 | The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gen e that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013] | 14 | 20684560 | 20701216 | Human | 195 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11709707 | RNASE4 | ribonuclease A family member 4 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular regio n (inferred); extracellular space (inferred) | 14 | 1548729 | 1564819 | Bonobo | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12151479 | RNASE4 | ribonuclease, RNase A family, 4 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular regio n (inferred); extracellular space (inferred) | 15 | 17981661 | 17998644 | Dog | 17 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12625247 | Rnase4 | ribonuclease A family member 4 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular regio n (inferred); extracellular space (inferred) | NW_004936880 | 41940 | 42988 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626185793 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626172341 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626177096 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14068090 | RNASE4 | ribonuclease A family member 4 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN antibacterial humoral response (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplas ms (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 20 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626172250 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626171128 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18600958 | RNASE4 | ribonuclease A family member 4 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); nuclease activity (inferred); INVOLVED IN cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular regio n (inferred); extracellular space (inferred) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626083564 | Rnase4 | ribonuclease A family member 4 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular region (ortholog); extr acellular space (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626177810 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626186655 | rnase4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 1349500 | ANG | angiogenin | The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis a fter binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020] | 14 | 20684177 | 20694186 | Human | 363 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 18915840 | LOC101707085 | ribonuclease 4 | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); lyase activity (inferred); INVOLVED IN defense response to bacterium (inferred); defense response to Gram-positive bacterium (inferred); FOUND IN extracellular region (inferred); extracellular space (inf erred) | | | | Naked Mole-Rat | 11 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8975883 | LOC102027574 | ribonuclease 4 | | NW_004955550 | 1505677 | 1524508 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16562056 | AL163636.1 | novel protein, ANG-RNASE4 readthrough | | | | | Human | | name | gene, protein-coding |
| 18183029 | EGILA | EGFR interacting lncRNA | | 14 | 20693480 | 20706941 | Human | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 14013658 | ANG | angiogenin | ENCODES a protein that exhibits protein homodimerization activity (ortholog); tRNA-specific ribonuclease activity (ortholog); INVOLVED IN angiogenesis (ortholog); hematopoietic stem cell proliferation (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Acute-Phase Reacti on (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endocytic vesicle (ortholog); extracellular space (ortholog) | | | | Pig | 110 | ensembl_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
