| 620003 | Rgs14 | regulator of G-protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase activator activity; INVOLVED IN negative regulation of ERK1 and ERK2 cascade; nucleocytoplasmic transport; platelet-derived growth factor receptor signaling pathway; ASSOCIATED WITH nephrolit hiasis (ortholog); FOUND IN centrosome; cytoplasm; dendrite; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 17 | 9254112 | 9268233 | Rat | 211 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733515 | RGS14 | regulator of G protein signaling 14 | This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of act ivated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] | 5 | 177357924 | 177372596 | Human | 167 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733516 | Rgs14 | regulator of G-protein signaling 14 | Enables GTPase activating protein binding activity and GTPase activator activity. Involved in several processes, including learning or memory; negative regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within mitotic cell cycle. Located in several cellular components, including dendritic spine; microtubule cytoskeleton; and nuclear body. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including cochlea; neural ectoderm; and placenta. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 55517269 | 55532504 | Mouse | 192 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8841742 | Rgs14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GDP-dissociation inhibitor activity (ortholog); GTPase activating protein binding (ortholog); INVOLVED IN cell division (ortholog); chromosome segregation (ortholog); learning (ortholog); ASSOCIATED WITH nephrolithiasis (ort holog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004955408 | 29602654 | 29616793 | Chinchilla | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12040903 | RGS14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); protein kinase binding (ortholog); signaling receptor complex adaptor activity (ortholog); INVOLVED IN mitotic cell cycle (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of MAP kinase activity (ortholog); ASSOCIATED WITH nephrolithiasis (ortholog); FOUND IN dendrite (ortholog); postsynaptic density (ortholog) | 5 | 172659323 | 172674084 | Bonobo | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12143480 | RGS14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activating protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN chromosome segregation (ortholog); learning (ortholog); mitotic cell cycle (ortholog); ASSOCIATED WITH nephrolithiasis (ortholog); FOUND IN dendrite (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog) | 4 | 35984970 | 35999386 | Dog | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12593589 | Rgs14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); protein kinase binding (ortholog); signaling receptor complex adaptor activity (ortholog); INVOLVED IN mitotic cell cycle (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of MAP kinase activity (ortholog); ASSOCIATED WITH nephrolithiasis (ortholog); FOUND IN dendrite (ortholog); postsynaptic density (ortholog) | NW_004936597 | 1650480 | 1658823 | Squirrel | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284352174 | rgs14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625851435 | Rgs14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GDP-dissociation inhibitor activity (ortholog); GTPase activating protein binding (ortholog); INVOLVED IN cell division (ortholog); chromosome segregation (ortholog); learning (ortholog); ASSOCIATED WITH nephrolithiasis (ort holog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Black Rat | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934508 | Rgs14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GDP-dissociation inhibitor activity (ortholog); GTPase activating protein binding (ortholog); INVOLVED IN chromosome segregation (ortholog); long-term memory (ortholog); long-term synaptic potentiation (ortholog); ASSOCIATED WITH nephrolithiasis (ortholog); FOUND IN dendrite (ortholog); glutamatergic synapse (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13964865 | RGS14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); protein kinase binding (ortholog); signaling receptor complex adaptor activity (ortholog); INVOLVED IN mitotic cell cycle (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of MAP kinase activity (ortholog); ASSOCIATED WITH nephrolithiasis (ortholog); FOUND IN dendrite (ortholog); postsynaptic density (ortholog); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 91 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18794853 | RGS14 | regulator of G protein signaling 14 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); protein kinase binding (ortholog); signaling receptor complex adaptor activity (ortholog); INVOLVED IN mitotic cell cycle (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of MAP kinase activity (ortholog); ASSOCIATED WITH nephrolithiasis (ortholog); FOUND IN dendrite (ortholog); postsynaptic density (ortholog) | | | | Green Monkey | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285971553 | rgs14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284351916 | rgs14.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11238 | Rgs16 | regulator of G-protein signaling 16 | Enables GTPase activator activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of GTPase activity. Located in membrane. Is expressed in several structures, including central nervous system; limb mesenchyme; lip; neural retina; and skeletal musculature. Orthologou s to human RGS16 (regulator of G protein signaling 16). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 153616099 | 153621212 | Mouse | 274 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1343291 | RGS16 | regulator of G protein signaling 16 | The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by Ref Seq, Jul 2008] | 1 | 182598623 | 182604389 | Human | 263 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |