RGS16 (regulator of G protein signaling 16) - Rat Genome Database

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Gene: RGS16 (regulator of G protein signaling 16) Homo sapiens
Analyze
Symbol: RGS16
Name: regulator of G protein signaling 16
RGD ID: 1343291
HGNC Page HGNC:9997
Description: Enables GTPase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Part of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A28-RGS14; A28-RGS14P; hRGS-r; regulator of G-protein signaling 16; regulator of G-protein signalling 16; retinal-specific RGS; retinally abundant regulator of G-protein signaling; RGS-R
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,598,623 - 182,604,389 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,598,623 - 182,604,389 (-)EnsemblGRCh38hg38GRCh38
GRCh371182,567,758 - 182,573,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,834,381 - 180,840,171 (-)NCBINCBI36Build 36hg18NCBI36
Build 341179,299,415 - 179,305,200NCBI
Celera1155,678,992 - 155,684,782 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,804,224 - 153,810,014 (-)NCBIHuRef
CHM1_11183,991,292 - 183,997,081 (-)NCBICHM1_1
T2T-CHM13v2.01181,958,121 - 181,963,886 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
15-acetyldeoxynivalenol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrylamide  (EXP)
adenine  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
curcumin  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (ISO)
disulfiram  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (EXP)
fenofibrate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fumonisin B1  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
hydroxyurea  (EXP)
imidacloprid  (ISO)
indole-3-methanol  (ISO)
inulin  (ISO)
itraconazole  (ISO)
kainic acid  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
leflunomide  (ISO)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
melphalan  (EXP)
menadione  (EXP)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N(6)-dimethylallyladenine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
orphenadrine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
propiconazole  (ISO)
protein kinase inhibitor  (EXP)
raloxifene  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
theophylline  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zaragozic acid A  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
membrane  (IEA,ISS)
plasma membrane  (TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:8917514   PMID:9079700   PMID:9223279   PMID:9271201   PMID:9469939   PMID:10072511   PMID:10373502   PMID:10747990   PMID:10760272   PMID:10791963   PMID:10836135   PMID:10878019  
PMID:11522288   PMID:11602604   PMID:12477932   PMID:12588871   PMID:12642592   PMID:12642593   PMID:14634662   PMID:15215290   PMID:15489334   PMID:15998835   PMID:16344560   PMID:17347170  
PMID:17613536   PMID:17635928   PMID:18262772   PMID:18434541   PMID:18521847   PMID:19509421   PMID:19760045   PMID:20571966   PMID:20627871   PMID:21135262   PMID:21784977   PMID:21988832  
PMID:23248035   PMID:23354309   PMID:25366993   PMID:26013170   PMID:26823172   PMID:28502923   PMID:30117167   PMID:32319728   PMID:35748872   PMID:35830366   PMID:36414916   PMID:36443250  
PMID:37473526  


Genomics

Comparative Map Data
RGS16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,598,623 - 182,604,389 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,598,623 - 182,604,389 (-)EnsemblGRCh38hg38GRCh38
GRCh371182,567,758 - 182,573,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361180,834,381 - 180,840,171 (-)NCBINCBI36Build 36hg18NCBI36
Build 341179,299,415 - 179,305,200NCBI
Celera1155,678,992 - 155,684,782 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,804,224 - 153,810,014 (-)NCBIHuRef
CHM1_11183,991,292 - 183,997,081 (-)NCBICHM1_1
T2T-CHM13v2.01181,958,121 - 181,963,886 (-)NCBIT2T-CHM13v2.0
Rgs16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,616,099 - 153,621,212 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,616,095 - 153,621,214 (+)EnsemblGRCm39 Ensembl
GRCm381153,740,353 - 153,745,468 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,740,349 - 153,745,468 (+)EnsemblGRCm38mm10GRCm38
MGSCv371155,587,483 - 155,592,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,502,566 - 155,507,684 (+)NCBIMGSCv36mm8
Celera1156,172,183 - 156,177,294 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.43NCBI
Rgs16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,421,480 - 68,443,312 (+)NCBIGRCr8
mRatBN7.21365,887,668 - 65,892,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,887,530 - 65,892,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,488,860 - 68,492,298 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,779,050 - 69,782,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01367,032,029 - 67,035,429 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,163,411 - 71,185,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,179,910 - 71,185,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01376,128,653 - 76,150,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,807,863 - 68,811,307 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1365,788,298 - 65,791,737 (+)NCBICelera
Cytogenetic Map13q21NCBI
Rgs16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,439,272 - 21,445,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540621,439,536 - 21,444,822 (-)NCBIChiLan1.0ChiLan1.0
RGS16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2167,124,524 - 67,130,751 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,808,016 - 66,814,241 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,117,257 - 158,123,031 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,768,921 - 161,774,709 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,765,595 - 161,774,709 (-)Ensemblpanpan1.1panPan2
RGS16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,009,283 - 16,015,228 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,009,271 - 16,015,597 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha715,595,717 - 15,601,663 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0715,738,716 - 15,744,653 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,739,616 - 15,744,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,650,339 - 15,656,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,758,624 - 15,764,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0715,887,673 - 15,893,854 (-)NCBIUU_Cfam_GSD_1.0
Rgs16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,300,380 - 89,305,804 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364817,147,013 - 7,152,565 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364817,147,147 - 7,152,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9123,913,173 - 123,918,871 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19123,913,179 - 123,919,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29136,173,524 - 136,175,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,764,097 - 46,769,895 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,764,134 - 46,769,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,982,051 - 47,987,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481411,249,335 - 11,255,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481411,249,448 - 11,254,728 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RGS16
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q25.1-31.1(chr1:175035040-186042595)x1 copy number loss See cases [RCV000051221] Chr1:175035040..186042595 [GRCh38]
Chr1:175004176..186011727 [GRCh37]
Chr1:173270799..184278350 [NCBI36]
Chr1:1q25.1-31.1
pathogenic
GRCh38/hg38 1q25.3-31.1(chr1:182137726-186931125)x1 copy number loss See cases [RCV000053949] Chr1:182137726..186931125 [GRCh38]
Chr1:182106861..186900257 [GRCh37]
Chr1:180373484..185166880 [NCBI36]
Chr1:1q25.3-31.1
pathogenic
GRCh38/hg38 1q25.2-32.1(chr1:179032905-199724897)x1 copy number loss See cases [RCV000053948] Chr1:179032905..199724897 [GRCh38]
Chr1:179002040..199694025 [GRCh37]
Chr1:177268663..197960648 [NCBI36]
Chr1:1q25.2-32.1
pathogenic
GRCh38/hg38 1q25.2-31.3(chr1:176595962-196301688)x1 copy number loss See cases [RCV000134144] Chr1:176595962..196301688 [GRCh38]
Chr1:176565098..196270818 [GRCh37]
Chr1:174831721..194537441 [NCBI36]
Chr1:1q25.2-31.3
pathogenic
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1
pathogenic
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2
pathogenic
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1
pathogenic
GRCh37/hg19 1q25.3-31.2(chr1:181572003-191524283)x1 copy number loss See cases [RCV000240242] Chr1:181572003..191524283 [GRCh37]
Chr1:1q25.3-31.2
pathogenic
NM_002928.4(RGS16):c.398A>G (p.Asp133Gly) single nucleotide variant not specified [RCV004285685] Chr1:182600503 [GRCh38]
Chr1:182569638 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q25.2-25.3(chr1:179564752-183850820)x1 copy number loss See cases [RCV000448646] Chr1:179564752..183850820 [GRCh37]
Chr1:1q25.2-25.3
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265)x1 copy number loss See cases [RCV000448809] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q25.3(chr1:180830413-183981164)x3 copy number gain See cases [RCV000448160] Chr1:180830413..183981164 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758)x1 copy number loss See cases [RCV000448686] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179011314-199022759)x1 copy number loss See cases [RCV000512128] Chr1:179011314..199022759 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.1-25.3(chr1:173138799-185129406)x3 copy number gain See cases [RCV000512520] Chr1:173138799..185129406 [GRCh37]
Chr1:1q25.1-25.3
likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.1-31.1(chr1:173131908-187406532)x1 copy number loss not provided [RCV000736735] Chr1:173131908..187406532 [GRCh37]
Chr1:1q25.1-31.1
pathogenic
GRCh37/hg19 1q25.3(chr1:182538615-182569626)x1 copy number loss not provided [RCV000749254] Chr1:182538615..182569626 [GRCh37]
Chr1:1q25.3
benign
GRCh37/hg19 1q25.3(chr1:181863430-183148056)x1 copy number loss not provided [RCV000762696] Chr1:181863430..183148056 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.551C>T (p.Ala184Val) single nucleotide variant not specified [RCV004285935] Chr1:182600350 [GRCh38]
Chr1:182569485 [GRCh37]
Chr1:1q25.3
uncertain significance
NC_000001.10:g.172652343_183538289del10885947 deletion 1q24q25 microdeletion syndrome [RCV000785662] Chr1:172652343..183538289 [GRCh37]
Chr1:1q24.3-25.3
pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q25.3(chr1:180586428-183178629)x3 copy number gain not provided [RCV001005158] Chr1:180586428..183178629 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:177551193-199599056)x1 copy number loss not provided [RCV001005157] Chr1:177551193..199599056 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q25.1-25.3(chr1:173162501-182702252)x3 copy number gain not provided [RCV001258487] Chr1:173162501..182702252 [GRCh37]
Chr1:1q25.1-25.3
pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265) copy number loss not specified [RCV002053769] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758) copy number loss not specified [RCV002053736] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3
pathogenic
GRCh37/hg19 1q25.3(chr1:180830413-183981164) copy number gain not specified [RCV002053802] Chr1:180830413..183981164 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q25.2-31.1(chr1:178522021-190322133)x1 copy number loss not provided [RCV001836604] Chr1:178522021..190322133 [GRCh37]
Chr1:1q25.2-31.1
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737) copy number loss not specified [RCV002053780] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
NC_000001.10:g.(?_179520308)_(183559464_?)dup duplication Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 2 [RCV002014062] Chr1:179520308..183559464 [GRCh37]
Chr1:1q25.2-25.3
uncertain significance
NM_002928.4(RGS16):c.539T>C (p.Leu180Pro) single nucleotide variant not specified [RCV004323827] Chr1:182600362 [GRCh38]
Chr1:182569497 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q25.2-31.2(chr1:179727182-192260142)x1 copy number loss not provided [RCV002473949] Chr1:179727182..192260142 [GRCh37]
Chr1:1q25.2-31.2
pathogenic
GRCh37/hg19 1q25.3(chr1:182443031-182609230)x1 copy number loss not provided [RCV002472741] Chr1:182443031..182609230 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q25.3(chr1:182442865-182609349)x1 copy number loss not provided [RCV002475783] Chr1:182442865..182609349 [GRCh37]
Chr1:1q25.3
uncertain significance
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3
pathogenic
NM_002928.4(RGS16):c.133G>A (p.Gly45Ser) single nucleotide variant not specified [RCV004215063] Chr1:182603251 [GRCh38]
Chr1:182572386 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.478C>T (p.Arg160Cys) single nucleotide variant not specified [RCV004230524] Chr1:182600423 [GRCh38]
Chr1:182569558 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.532C>T (p.Arg178Trp) single nucleotide variant not specified [RCV004152825] Chr1:182600369 [GRCh38]
Chr1:182569504 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.19G>A (p.Ala7Thr) single nucleotide variant not specified [RCV004287017] Chr1:182604241 [GRCh38]
Chr1:182573376 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.124T>C (p.Phe42Leu) single nucleotide variant not specified [RCV004279258] Chr1:182603260 [GRCh38]
Chr1:182572395 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.145A>G (p.Ser49Gly) single nucleotide variant not specified [RCV004252700] Chr1:182603239 [GRCh38]
Chr1:182572374 [GRCh37]
Chr1:1q25.3
likely benign
GRCh37/hg19 1q25.1-25.3(chr1:173162501-182702252)x3 copy number gain not specified [RCV003986506] Chr1:173162501..182702252 [GRCh37]
Chr1:1q25.1-25.3
pathogenic
GRCh37/hg19 1q24.2-31.1(chr1:167994071-187711459)x1 copy number loss not specified [RCV003987250] Chr1:167994071..187711459 [GRCh37]
Chr1:1q24.2-31.1
pathogenic
NM_002928.4(RGS16):c.343C>A (p.His115Asn) single nucleotide variant not specified [RCV004449139] Chr1:182602010 [GRCh38]
Chr1:182571145 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.419C>T (p.Thr140Met) single nucleotide variant not specified [RCV004449140] Chr1:182600482 [GRCh38]
Chr1:182569617 [GRCh37]
Chr1:1q25.3
uncertain significance
NM_002928.4(RGS16):c.544G>A (p.Ala182Thr) single nucleotide variant not specified [RCV004449141] Chr1:182600357 [GRCh38]
Chr1:182569492 [GRCh37]
Chr1:1q25.3
uncertain significance
NC_000001.10:g.(?_179520308)_(183559464_?)del deletion not provided [RCV004579068] Chr1:179520308..183559464 [GRCh37] pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1204
Count of miRNA genes:572
Interacting mature miRNAs:631
Transcripts:ENST00000367558
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98871  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371182,567,813 - 182,567,967UniSTSGRCh37
Build 361180,834,436 - 180,834,590RGDNCBI36
Celera1155,679,047 - 155,679,201RGD
Cytogenetic Map1q25-q31UniSTS
HuRef1153,804,279 - 153,804,433UniSTS
GeneMap99-GB4 RH Map1633.62UniSTS
RGS16_778  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371182,567,759 - 182,568,609UniSTSGRCh37
Build 361180,834,382 - 180,835,232RGDNCBI36
Celera1155,678,993 - 155,679,843RGD
HuRef1153,804,225 - 153,805,075UniSTS
SHGC-76000  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371182,567,800 - 182,568,003UniSTSGRCh37
Build 361180,834,423 - 180,834,626RGDNCBI36
Celera1155,679,034 - 155,679,237RGD
Cytogenetic Map1q25-q31UniSTS
HuRef1153,804,266 - 153,804,469UniSTS
TNG Radiation Hybrid Map186357.0UniSTS
GeneMap99-GB4 RH Map1634.34UniSTS
Whitehead-RH Map1792.2UniSTS
RH70699  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q25-q31UniSTS
GeneMap99-GB4 RH Map1629.89UniSTS
NCBI RH Map11563.6UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3
Medium 1012 1026 1174 189 819 139 1517 457 1367 196 292 1425 54 1 770 890 4
Low 1414 1704 529 421 820 309 2691 1599 2328 189 1139 132 119 430 1768 2 2
Below cutoff 12 261 16 9 297 12 148 136 32 24 22 41 1 4 130

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF009356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF493937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW193671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA060276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC349953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U94829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000367558   ⟹   ENSP00000356529
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1182,598,623 - 182,604,389 (-)Ensembl
RefSeq Acc Id: NM_002928   ⟹   NP_002919
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381182,598,623 - 182,604,389 (-)NCBI
GRCh371182,567,758 - 182,573,548 (-)ENTREZGENE
GRCh371182,567,758 - 182,573,548 (-)NCBI
Build 361180,834,381 - 180,840,171 (-)NCBI Archive
HuRef1153,804,224 - 153,810,014 (-)ENTREZGENE
CHM1_11183,991,292 - 183,997,081 (-)NCBI
T2T-CHM13v2.01181,958,121 - 181,963,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448796   ⟹   XP_024304564
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381182,598,623 - 182,604,389 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054338046   ⟹   XP_054194021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01181,958,121 - 181,963,886 (-)NCBI
RefSeq Acc Id: NP_002919   ⟸   NM_002928
- UniProtKB: Q5VYN9 (UniProtKB/Swiss-Prot),   B2R4M4 (UniProtKB/Swiss-Prot),   Q99701 (UniProtKB/Swiss-Prot),   O15492 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024304564   ⟸   XM_024448796
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000356529   ⟸   ENST00000367558
RefSeq Acc Id: XP_054194021   ⟸   XM_054338046
- Peptide Label: isoform X1
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O15492-F1-model_v2 AlphaFold O15492 1-202 view protein structure

Promoters
RGD ID:6809686
Promoter ID:HG_ACW:5053
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid
Transcripts:RGS16.BAPR07,   RGS16.DAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361180,838,784 - 180,839,284 (-)MPROMDB
RGD ID:6786423
Promoter ID:HG_KWN:6462
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002928
Position:
Human AssemblyChrPosition (strand)Source
Build 361180,839,894 - 180,840,394 (-)MPROMDB
RGD ID:6858314
Promoter ID:EPDNEW_H2322
Type:multiple initiation site
Name:RGS16_1
Description:regulator of G protein signaling 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381182,604,389 - 182,604,449EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9997 AgrOrtholog
COSMIC RGS16 COSMIC
Ensembl Genes ENSG00000143333 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367558 ENTREZGENE
  ENST00000367558.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  1.10.196.10 UniProtKB/Swiss-Prot
GTEx ENSG00000143333 GTEx
HGNC ID HGNC:9997 ENTREZGENE
Human Proteome Map RGS16 Human Proteome Map
InterPro RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdom1/3 UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
KEGG Report hsa:6004 UniProtKB/Swiss-Prot
NCBI Gene 6004 ENTREZGENE
OMIM 602514 OMIM
PANTHER REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot
  REGULATOR OF G-PROTEIN SIGNALING 16 UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PharmGKB PA34367 PharmGKB
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE RGS UniProtKB/Swiss-Prot
SMART RGS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
UniProt B2R4M4 ENTREZGENE
  O15492 ENTREZGENE
  Q5VYN9 ENTREZGENE
  Q99701 ENTREZGENE
  RGS16_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R4M4 UniProtKB/Swiss-Prot
  Q5VYN9 UniProtKB/Swiss-Prot
  Q99701 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 RGS16  regulator of G protein signaling 16  RGS16  regulator of G-protein signaling 16  Symbol and/or name change 5135510 APPROVED