ENCODES a protein that exhibits kinase activator activity; protein kinase binding; protein kinase activator activity (ortholog); INVOLVED IN positive regulation of mitotic cell cycle; cellular response to hypoxia (ortholog); complement receptor mediated signaling pathway (ortholog); ASSOCIATED WITH
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis
. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
Predicted to enable R-SMAD binding activity; protein kinase activator activity; and protein kinase binding activity. Involved in fibroblast activation. Predicted to be located in centrosome; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, includin
g alimentary system; central nervous system; hindlimb interdigital region mesenchyme; liver; and male reproductive gland or organ. Orthologous to human RGCC (regulator of cell cycle). [provided by Alliance of Genome Resources, Jul 2025]
ENCODES a protein that exhibits kinase activator activity (ortholog); INVOLVED IN negative regulation of cell-cell adhesion mediated by cadherin (ortholog); negative regulation of cytokine production (ortholog); positive regulation of collagen biosynthetic process (ortholog); ASSOCIATED WITH basal c