Rgcc (regulator of cell cycle) - Rat Genome Database

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Gene: Rgcc (regulator of cell cycle) Mus musculus
Analyze
Symbol: Rgcc
Name: regulator of cell cycle
RGD ID: 733141
MGI Page MGI
Description: Predicted to have R-SMAD binding activity; protein kinase activator activity; and protein kinase binding activity. Involved in fibroblast activation. Predicted to localize to centrosome; cytoplasm; and nuclear lumen. Is expressed in several structures, including alimentary system; central nervous system; hindlimb interdigital region mesenchyme; liver; and male reproductive gland or organ. Orthologous to human RGCC (regulator of cell cycle); INTERACTS WITH 1,2-dimethylhydrazine; buta-1,3-diene; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1190002H23Rik; regulator of cell cycle RGCC; response gene to complement 32 protein; RGC-3; Rgc-32; Rgc32
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391479,526,190 - 79,539,075 (-)NCBIGRCm39mm39
GRCm39 Ensembl1479,526,196 - 79,539,085 (-)Ensembl
GRCm381479,288,750 - 79,301,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1479,288,756 - 79,301,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv371479,688,557 - 79,701,442 (-)NCBIGRCm37mm9NCBIm37
MGSCv361478,022,906 - 78,035,790 (-)NCBImm8
Celera1476,789,236 - 76,802,360 (-)NCBICelera
Cytogenetic Map14D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
carmustine  (ISO)
chloroprene  (EXP)
cholesterol  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
folic acid  (EXP)
genistein  (EXP)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
menadione  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resorcinol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hypoxia  (ISO)
complement activation  (ISO)
fibroblast activation  (IMP)
G1/S transition of mitotic cell cycle  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of exit from mitosis  (ISO)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of mitotic cell cycle phase transition  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell cycle  (ISO)

Cellular Component
centrosome  (ISO)
cytoplasm  (IBA,ISO)
cytoskeleton  (IEA)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11687586   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17327222  
PMID:21267068   PMID:21613609   PMID:21677750   PMID:21873635   PMID:21990365   PMID:23431145   PMID:23695833   PMID:24194600   PMID:24973210   PMID:25385871   PMID:25770350   PMID:26134570  
PMID:26275310   PMID:26839965   PMID:27626380   PMID:28356385   PMID:29279353   PMID:29449334   PMID:29507108   PMID:29579398   PMID:29636874   PMID:30006805   PMID:30355157   PMID:30453650  
PMID:30598549  


Genomics

Comparative Map Data
Rgcc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391479,526,190 - 79,539,075 (-)NCBIGRCm39mm39
GRCm39 Ensembl1479,526,196 - 79,539,085 (-)Ensembl
GRCm381479,288,750 - 79,301,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1479,288,756 - 79,301,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv371479,688,557 - 79,701,442 (-)NCBIGRCm37mm9NCBIm37
MGSCv361478,022,906 - 78,035,790 (-)NCBImm8
Celera1476,789,236 - 76,802,360 (-)NCBICelera
Cytogenetic Map14D3NCBI
RGCC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1341,457,550 - 41,470,871 (+)EnsemblGRCh38hg38GRCh38
GRCh381341,457,411 - 41,470,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371342,031,686 - 42,045,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,929,542 - 40,943,013 (+)NCBINCBI36hg18NCBI36
Build 341340,929,711 - 40,943,007NCBI
Celera1323,088,009 - 23,101,472 (+)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1322,831,152 - 22,844,599 (+)NCBIHuRef
CHM1_11341,999,088 - 42,012,524 (+)NCBICHM1_1
Rgcc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21554,662,483 - 54,675,320 (-)NCBI
Rnor_6.0 Ensembl1561,551,861 - 61,564,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01561,551,861 - 61,564,695 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01565,214,322 - 65,227,218 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41560,451,831 - 60,452,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11560,467,610 - 60,468,001 (-)NCBI
Celera1554,246,727 - 54,259,558 (-)NCBICelera
Cytogenetic Map15q12NCBI
Rgcc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555184,788,656 - 4,801,204 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555184,788,857 - 4,800,273 (-)NCBIChiLan1.0ChiLan1.0
RGCC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11341,228,643 - 41,241,909 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1341,228,643 - 41,241,909 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01322,639,289 - 22,652,594 (+)NCBIMhudiblu_PPA_v0panPan3
RGCC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,199,204 - 9,209,297 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha229,192,421 - 9,210,192 (-)NCBI
ROS_Cfam_1.0229,422,365 - 9,439,870 (-)NCBI
UMICH_Zoey_3.1229,118,026 - 9,135,425 (-)NCBI
UNSW_CanFamBas_1.0229,167,964 - 9,185,229 (-)NCBI
UU_Cfam_GSD_1.0229,179,949 - 9,199,706 (-)NCBI
Rgcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945151,654,293 - 151,666,885 (+)NCBI
SpeTri2.0NW_004936667232,807 - 245,131 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGCC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1125,478,877 - 25,496,519 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11125,481,845 - 25,496,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,202,900 - 26,215,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGCC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1319,681,700 - 19,695,655 (+)NCBI
ChlSab1.1 Ensembl319,681,874 - 19,693,644 (+)Ensembl
Vero_WHO_p1.0NW_02366605724,523,086 - 24,537,162 (-)NCBI
Rgcc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474813,710,901 - 13,722,951 (-)NCBI

Position Markers
UniSTS:224335  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381479,294,570 - 79,294,738UniSTSGRCm38
MGSCv371479,694,377 - 79,694,545UniSTSGRCm37
Cytogenetic Map14D3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143060000087700000Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144921797683218107Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145204453586044676Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145352385687524089Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145370000087700000Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145584494189845069Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145630930590309501Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1457942183101622037Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146216002096160240Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1469834541103834541Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470626332104626490Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1470983788104983908Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474114860108114948Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474157540108157657Mouse
14928314Manh77_mmandible shape 77 (mouse)1476530354110530354Mouse
1558823Tbbmd6_mtotal body bone mineral density 6 (mouse)Not determined1476836260110836351Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:381
Count of miRNA genes:267
Interacting mature miRNAs:305
Transcripts:ENSMUST00000022595
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022595   ⟹   ENSMUSP00000022595
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1479,288,756 - 79,301,645 (-)Ensembl
RefSeq Acc Id: NM_025427   ⟹   NP_079703
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391479,526,190 - 79,539,075 (-)NCBI
GRCm381479,288,750 - 79,301,635 (-)NCBI
MGSCv371479,688,557 - 79,701,442 (-)RGD
Celera1476,789,236 - 76,802,360 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_079703   ⟸   NM_025427
- UniProtKB: Q9DBX1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022595   ⟸   ENSMUST00000022595

Promoters
RGD ID:8683062
Promoter ID:EPDNEW_M19562
Type:multiple initiation site
Name:Rgcc_1
Description:Mus musculus regulator of cell cycle , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381479,301,630 - 79,301,690EPDNEW
RGD ID:6847075
Promoter ID:MM_ACW:16726
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6
Transcripts:1190002H23RIK.BSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361479,690,146 - 79,690,646 (-)MPROMDB
RGD ID:6824541
Promoter ID:MM_KWN:17550
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_025427
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361479,701,106 - 79,701,606 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913464 AgrOrtholog
Ensembl Genes ENSMUSG00000022018 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022595 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022595 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro RGCC UniProtKB/Swiss-Prot
KEGG Report mmu:66214 UniProtKB/Swiss-Prot
MGD MGI:1913464 ENTREZGENE
NCBI Gene 66214 ENTREZGENE
PANTHER PTHR32193 UniProtKB/Swiss-Prot
Pfam RGCC UniProtKB/Swiss-Prot
PhenoGen Rgcc PhenoGen
UniProt Q9DBX1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9D0U0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Rgcc  regulator of cell cycle  1190002H23Rik  RIKEN cDNA 1190002H23 gene  Symbol and/or name change 5135510 APPROVED