| 3552 | Reg1a | regenerating family member 1 alpha | ENCODES a protein that exhibits growth factor activity; identical protein binding; phosphatase binding; INVOLVED IN cellular response to chemokine; cellular response to gastrin; liver regeneration; ASSOCIATED WITH Acute Experimental Pancreatitis; chronic pancreatitis; colon cancer; FOUND IN basal pa rt of cell; dendrite membrane; extracellular space; INTERACTS WITH acetylsalicylic acid; alpha-Zearalanol; ammonium chloride | 4 | 112450466 | 112453130 | Rat | 121 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 737018 | REG1A | regenerating family member 1 alpha | This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associa ted with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008] | 2 | 79120488 | 79123409 | Human | 122 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 12439707 | Reg1a | regenerating family member 1 alpha | ENCODES a protein that exhibits identical protein binding (ortholog); phosphatase binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN cellular response to chemokine (ortholog); cellular response to gastrin (ortholog); gene expression (ortholog); ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Calcific Pancreatitis (ortholog); FOUND IN basal part of cell (ortholog); dendrite membrane (ortholog); extracellular space (ortholog) | NW_004936556 | 4873331 | 4875608 | Squirrel | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626188340 | reg1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626174580 | reg1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179522 | reg1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18923512 | Reg1a | regenerating family member 1 alpha | ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); molecular function inhibitor activity (ortholog); INVOLVED IN cellular response to chemokine (ortholog); cellular response to gastrin (ortholog); gene expression (ortholog); ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Calcific Pancreatitis (ortholog); FOUND IN basal part of cell (ortholog); dendrite membrane (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11721837 | LOC100992526 | lithostathine-1-alpha | ENCODES a protein that exhibits carbohydrate binding (inferred); growth factor activity (inferred); molecular function inhibitor activity (inferred); INVOLVED IN signal transduction (inferred); FOUND IN extracellular region (inferred) | 2A | 79206709 | 79209940 | Bonobo | 5 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1346386 | REG1B | regenerating family member 1 beta | This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008] | 2 | 79085023 | 79087993 | Human | 42 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 18513222 | LOC103219987 | lithostathine-1-alpha | ENCODES a protein that exhibits carbohydrate binding (inferred); growth factor activity (inferred); molecular function inhibitor activity (inferred); INVOLVED IN signal transduction (inferred); FOUND IN extracellular region (inferred) | | | | Green Monkey | 5 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 737019 | Reg1 | regenerating islet-derived 1 | Predicted to enable several functions, including growth factor activity; identical protein binding activity; and peptidoglycan binding activity. Involved in several processes, including pancreas regeneration; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and type B pancreatic c ell differentiation. Acts upstream of or within with a positive effect on gene expression. Located in collagen-containing extracellular matrix. Is expressed in several structures, including esophagus; lung; and pancreas. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 78402966 | 78405651 | Mouse | 164 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1623283 | Reg2 | regenerating islet-derived 2 | Predicted to enable several functions, including molecular function inhibitor activity; oligosaccharide binding activity; and peptidoglycan binding activity. Acts upstream of or within myelination and suckling behavior. Located in collagen-containing extracellular matrix. Is expressed in several str uctures, including gut; male reproductive gland or organ; and mesenteric adipose tissue. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 78382138 | 78385082 | Mouse | 52 | description | gene, protein-coding, VALIDATED [RefSeq] |
