Reg2 (regenerating islet-derived 2) - Rat Genome Database
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Gene: Reg2 (regenerating islet-derived 2) Mus musculus
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Symbol: Reg2
Name: regenerating islet-derived 2
RGD ID: 1623283
MGI Page MGI
Description: Is expressed in several structures, including gut; male reproductive gland or organ; and mesenteric adipose tissue. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: islet of Langerhans regenerating protein 2; lithostathine-2; MGC107500; pancreatic stone protein 2; pancreatic thread protein 2; PSP; PTP; REG-2; regenerating islet-derived, mouse homolog 2; RegII
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,382,138 - 78,385,082 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,372,606 - 78,385,089 (+)Ensembl
GRCm38678,405,155 - 78,408,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,395,623 - 78,408,106 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,355,149 - 78,358,091 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,334,664 - 78,337,606 (+)NCBImm8
Celera680,428,136 - 80,431,078 (+)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8340418   PMID:8522062   PMID:8808978   PMID:8863190   PMID:9055810   PMID:10349636   PMID:10767532   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932  
PMID:16141072   PMID:16141073   PMID:17133485   PMID:17192462   PMID:17898082   PMID:18297134   PMID:18678917   PMID:20489047   PMID:20876350   PMID:20919961   PMID:21410322   PMID:21873635  
PMID:22252863   PMID:23147030   PMID:23867474   PMID:24194600   PMID:24801175   PMID:25370781   PMID:27524624   PMID:27626380   PMID:28009527   PMID:28071719   PMID:31597102  


Genomics

Comparative Map Data
Reg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,382,138 - 78,385,082 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,372,606 - 78,385,089 (+)Ensembl
GRCm38678,405,155 - 78,408,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,395,623 - 78,408,106 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,355,149 - 78,358,091 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,334,664 - 78,337,606 (+)NCBImm8
Celera680,428,136 - 80,431,078 (+)NCBICelera
Cytogenetic Map6C3NCBI
REG1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl279,085,023 - 79,088,019 (-)EnsemblGRCh38hg38GRCh38
GRCh38279,085,023 - 79,087,993 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37279,312,149 - 79,315,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36279,165,659 - 79,168,627 (-)NCBINCBI36hg18NCBI36
Build 34279,223,805 - 79,226,774NCBI
Celera279,140,874 - 79,143,875 (-)NCBI
Cytogenetic Map2p12NCBI
HuRef279,047,465 - 79,050,466 (-)NCBIHuRef
CHM1_1279,241,459 - 79,244,460 (-)NCBICHM1_1
LOC100993115
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A80,736,161 - 80,739,154 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A80,736,161 - 80,739,154 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A79,171,602 - 79,174,591 (-)NCBIMhudiblu_PPA_v0panPan3
LOC103219989
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11428,159,979 - 28,163,475 (+)NCBI
ChlSab1.1 Ensembl1428,160,506 - 28,163,996 (+)Ensembl

Position Markers
Reg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Cytogenetic Map6C-DUniSTS
cM Map633.5UniSTS
cM Map6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:77
Interacting mature miRNAs:77
Transcripts:ENSMUST00000023906
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023906   ⟹   ENSMUSP00000023906
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,405,158 - 78,408,106 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203657   ⟹   ENSMUSP00000145184
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,395,623 - 78,407,681 (+)Ensembl
RefSeq Acc Id: NM_009043   ⟹   NP_033069
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39678,382,138 - 78,385,082 (+)NCBI
GRCm38678,405,155 - 78,408,099 (+)NCBI
MGSCv37678,355,149 - 78,358,091 (+)RGD
Celera680,428,136 - 80,431,078 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033069 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98503 (Get FASTA)   NCBI Sequence Viewer  
  BAA03112 (Get FASTA)   NCBI Sequence Viewer  
  BAB25526 (Get FASTA)   NCBI Sequence Viewer  
  EDK99018 (Get FASTA)   NCBI Sequence Viewer  
  Q08731 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_033069   ⟸   NM_009043
- Peptide Label: precursor
- UniProtKB: Q08731 (UniProtKB/Swiss-Prot),   Q545J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145184   ⟸   ENSMUST00000203657
RefSeq Acc Id: ENSMUSP00000023906   ⟸   ENSMUST00000023906
Protein Domains
C-type lectin

Promoters
RGD ID:6890070
Promoter ID:EPDNEW_M8485
Type:single initiation site
Name:Reg2_1
Description:Mus musculus regenerating islet-derived 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,405,155 - 78,405,215EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97896 AgrOrtholog
Ensembl Genes ENSMUSG00000023140 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023906 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145184 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023906 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000203657 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19693 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97896 ENTREZGENE
NCBI Gene 19693 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg2 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVN9_MOUSE UniProtKB/TrEMBL
  LIT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q545J0 ENTREZGENE, UniProtKB/TrEMBL