| 1308872 | Rbbp8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN response to estradiol; blastocyst hatching (ortholog); DNA double-strand break processing involved in repa ir via single-strand annealing (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); site of double-strand break (ortholog); transcription repressor complex (ortholog); INTERACTS WITH acetamide; bisphenol A; endosulfan | 18 | 3198188 | 3263643 | Rat | 184 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317354 | RBBP8 | RB binding protein 8, endonuclease | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is th ought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] | 18 | 22914139 | 23026486 | Human | 324 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622091 | Rbbp8 | retinoblastoma binding protein 8, endonuclease | Predicted to enable several functions, including identical protein binding activity; single-stranded DNA endodeoxyribonuclease activity; and transcription corepressor activity. Acts upstream of or within G1/S transition of mitotic cell cycle and blastocyst hatching. Predicted to be located in nucleo plasm. Predicted to be part of BRCA1-C complex and transcription repressor complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 11766333 | 11876264 | Mouse | 216 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8741319 | Rbbp8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN blastocyst hatching (ortholog); DNA double-strand break processing involved in repair via single-strand an nealing (ortholog); DNA strand resection involved in replication fork processing (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN BRCA1-C complex (ortholog); nucleoplasm (ortholog); site of double-strand break (ortholog) | NW_004955402 | 11245857 | 11331872 | Chinchilla | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11880747 | RBBP8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); endonuclease activity (inferred); INVOLVED IN blastocyst hatching (ortholog); G1/S transition of mitotic cell cycle (ortholog); response to estradiol (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM ) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred) | 18 | 16181652 | 16274597 | Bonobo | 62 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12122317 | RBBP8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); endonuclease activity (inferred); INVOLVED IN blastocyst hatching (ortholog); G1/S transition of mitotic cell cycle (ortholog); response to estradiol (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM ) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred) | 7 | 65218288 | 65319696 | Dog | 62 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12486374 | Rbbp8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); endonuclease activity (inferred); INVOLVED IN blastocyst hatching (ortholog); G1/S transition of mitotic cell cycle (ortholog); response to estradiol (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM ) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936550 | 2482915 | 2554077 | Squirrel | 61 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14150588 | RBBP8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); endonuclease activity (inferred); INVOLVED IN blastocyst hatching (ortholog); G1/S transition of mitotic cell cycle (ortholog); response to estradiol (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM ) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 62 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18665205 | RBBP8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); endonuclease activity (inferred); INVOLVED IN blastocyst hatching (ortholog); G1/S transition of mitotic cell cycle (ortholog); response to estradiol (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM ) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 62 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18907676 | Rbbp8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); single-stranded DNA endodeoxyribonuclease activity (ortholog); INVOLVED IN blastocyst hatching (ortholog); DNA strand resection involved in replicatio n fork processing (ortholog); double-strand break repair via homologous recombination (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN BRCA1-C complex (ortholog); nucleoplasm (ortholog); site of double-strand break (ortholog) | | | | Naked Mole-Rat | 61 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 287286777 | rbbp8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625998636 | Rbbp8 | RB binding protein 8, endonuclease | ENCODES a protein that exhibits damaged DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN blastocyst hatching (ortholog); DNA double-strand break processing involved in repair via single-strand an nealing (ortholog); DNA strand resection involved in replication fork processing (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH COVID-19 (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN BRCA1-C complex (ortholog); nucleoplasm (ortholog); site of double-strand break (ortholog) | | | | Black Rat | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 288057188 | rbbp8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284859582 | rbbp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16564317 | RBBP8-AS1 | RBBP8 antisense RNA 1 | | 18 | 22723491 | 22933764 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5128967 | RBBP8P1 | RBBP8 pseudogene 1 | | X | 118632363 | 118634230 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5128966 | RBBP8P2 | RBBP8 pseudogene 2 | | 13 | 27077218 | 27077954 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1353930 | RBBP8NL | RBBP8 N-terminal like | Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 62410237 | 62427539 | Human | 24 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1596090 | Rbbp8nl | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog); INTERACTS WITH aflatoxin B1; alpha-Zearalanol; cadmium dichloride | 3 | 187741642 | 187756598 | Rat | 24 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1622869 | Rbbp8nl | RBBP8 N-terminal like | Orthologous to human RBBP8NL (RBBP8 N-terminal like). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 179917039 | 179931693 | Mouse | 27 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8952553 | Rbbp8nl | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog) | NW_004955528 | 1641291 | 1655920 | Chinchilla | 2 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11926314 | RBBP8NL | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog) | 20 | 58794817 | 58812530 | Bonobo | 2 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12386941 | RBBP8NL | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog) | 24 | 46377956 | 46393990 | Dog | 2 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12449027 | Rbbp8nl | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog) | NW_004936514 | 10016227 | 10023590 | Squirrel | 2 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14044243 | RBBP8NL | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog); INTERACTS WITH zearalenone | | | | Pig | 3 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18451298 | RBBP8NL | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog) | | | | Green Monkey | 2 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18900950 | Rbbp8nl | RBBP8 N-terminal like | ASSOCIATED WITH neuronal ceroid lipofuscinosis (ortholog) | | | | Naked Mole-Rat | 2 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625960875 | Rbbp8nl | RBBP8 N-terminal like | | | | | Black Rat | 1 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14146818 | LOC100155447 | DNA endonuclease RBBP8-like | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 14248786 | LOC100738404 | DNA endonuclease RBBP8-like | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 18934399 | LOC101706361 | DNA endonuclease RBBP8-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18902603 | LOC101725400 | DNA endonuclease RBBP8-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 12451155 | LOC101967318 | DNA endonuclease RBBP8-like | | NW_004936648 | 786096 | 788637 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12737576 | LOC101978659 | DNA endonuclease RBBP8-like | | NW_004936902 | 93507 | 96554 | Squirrel | | name | gene, pseudo, MODEL [RefSeq] |
| 18908478 | LOC106009180 | DNA endonuclease RBBP8-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 13250816 | LOC111094686 | DNA endonuclease RBBP8-like | | X | 90829810 | 90833069 | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 18904168 | LOC101701451 | DNA endonuclease RBBP8 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18936981 | LOC101707651 | DNA endonuclease RBBP8 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18906088 | LOC101721578 | DNA endonuclease RBBP8 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 8927467 | LOC102015369 | DNA endonuclease RBBP8 pseudogene | | NW_004955405 | 5020117 | 5022070 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 8917191 | LOC102027103 | DNA endonuclease RBBP8 pseudogene | | NW_004955432 | 5725983 | 5726747 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 13904877 | LOC102159992 | DNA endonuclease RBBP8 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 10132128 | LOC106146255 | DNA endonuclease RBBP8 pseudogene | | NW_004955405 | 5022538 | 5023461 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 16564158 | AC090912.1 | novel transcript, antisense to RBBP8 | | | | | Human | | name | gene, lncrna |
| 16566762 | AC090912.3 | novel transcript, sense intronic to RBBP8 | | | | | Human | | name | gene, lncrna |
| 15567395 | Gm50468 | predicted gene, 50468 | | | | | Mouse | | old_gene_name | gene, processed_pseudogene |
| 155248360 | rbbp8nl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155248498 | rbbp8nl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241531 | rbbp8nl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38659943 | LOC105372710 | uncharacterized LOC105372710 | | 20 | 62427830 | 62431509 | Human | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |