| 61908 | Rab7a | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits GDP binding; GTP binding; small GTPase binding; INVOLVED IN bone resorption; synaptic vesicle recycling via endosome; autophagosome assembly (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; endocytosis pathway; ASSOCIATED WITH Charcot-M arie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body; late endosome; presynaptic endosome; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 4 | 122019281 | 122068067 | Rat | 288 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1351789 | RAB7A | RAB7A, member RAS oncogene family | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and al so from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] | 3 | 128726183 | 128814798 | Human | 314 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8824296 | Rab7a | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); bone resorption (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASSOCIATE D WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); endosome membrane (ortholog) | NW_004955429 | 15103792 | 15167498 | Chinchilla | 91 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11714573 | RAB7A | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); bone resorption (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASSOCIATE D WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); endosome membrane (ortholog) | 3 | 125784604 | 125873051 | Bonobo | 91 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12154550 | RAB7A | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); small GTPase binding (ortholog); INVOLVED IN early endosome to late endosome transport; epidermal growth factor catabolic process; bone resorption (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling p athway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN exocytic vesicle; synaptic vesicle membrane; alveolar lamellar body (ortholog) | 20 | 2704716 | 2776518 | Dog | 102 | symbol , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12548729 | Rab7a | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); small GTPase binding (ortholog); INVOLVED IN bone resorption (ortholog); synaptic vesicle recycling via endosome (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Charcot-Ma rie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); endosome membrane (ortholog); exocytic vesicle (ortholog) | NW_004936798 | 297600 | 304929 | Squirrel | 109 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18932469 | Rab7a | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); bone resorption (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASS OCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); endosome membrane (ortholog) | | | | Naked Mole-Rat | 101 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 625988544 | Rab7a | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); bone resorption (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASSOCIATE D WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); endosome membrane (ortholog) | | | | Black Rat | 91 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18377371 | RAB7A | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); small GTPase binding (ortholog); INVOLVED IN bone resorption (ortholog); synaptic vesicle recycling via endosome (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Charcot-Ma rie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); endosome membrane (ortholog); exocytic vesicle (ortholog) | | | | Green Monkey | 109 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14188054 | RAB7A | RAB7A, member RAS oncogene family | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); small GTPase binding (ortholog); INVOLVED IN bone resorption (ortholog); synaptic vesicle recycling via endosome (ortholog); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Charcot-Ma rie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); Charcot-Marie-Tooth disease type 2B (ortholog); FOUND IN alveolar lamellar body (ortholog); endosome membrane (ortholog); exocytic vesicle (ortholog) | | | | Pig | 109 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155242826 | rab7a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155245803 | rab7a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241750 | rab7a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1591324 | Rab7a-ps1 | RAB7A, member RAS oncogene family, pseudogene 1 | | X | 25233206 | 25235008 | Rat | | symbol , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 62201 | Rab7 | RAB7, member RAS oncogene family | Predicted to enable several functions, including guanyl ribonucleotide binding activity; retromer complex binding activity; and small GTPase binding activity. Involved in lipophagy; neurotransmitter receptor transport, postsynaptic endosome to lysosome; and vesicle-mediated transport in synapse. Act s upstream of or within with a positive effect on establishment of vesicle localization. Located in several cellular components, including late endosome membrane; lipid droplet; and phagophore assembly site membrane. Is active in glutamatergic synapse and lysosome. Colocalizes with lysosomal membrane. Is expressed in several structures, including 1-cell stage embryo; cerebral cortex; lung mesenchyme; oocyte; and primitive endoderm. Used to study Charcot-Marie-Tooth disease type 2B. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 87976088 | 88022252 | Mouse | 257 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1305938 | Rimoc1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide | 2 | 54917383 | 54931577 | Rat | 35 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1314264 | Rimoc1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | Predicted to be involved in mitophagy. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including adipose tissue; ganglia; gut; hemolymphoid system; and male reproductive gland or organ. Orthologous to human RIMOC1 (RAB7A i nteracting MON1-CCZ1 complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 4011517 | 4025228 | Mouse | 47 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604481 | RIMOC1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | Involved in mitophagy. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 41904344 | 41921636 | Human | 35 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8707558 | Rimoc1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | NW_004955426 | 26026284 | 26040311 | Chinchilla | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 11952685 | RIMOC1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (inferred); FOUND IN cytosol (inferred); nucleoplasm (inferred) | 5 | 68477984 | 68495352 | Bonobo | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12313960 | RIMOC1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (inferred); FOUND IN cytosol (inferred); nucleoplasm (inferred); INTERACTS WITH bisphenol A | 4 | 67668727 | 67688509 | Dog | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 12715367 | Rimoc1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (inferred); FOUND IN cytosol (inferred); nucleoplasm (inferred) | NW_004936518 | 880781 | 897655 | Squirrel | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 18569136 | RIMOC1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (inferred); FOUND IN cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18921613 | Rimoc1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (inferred); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 625926401 | Rimoc1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 14089299 | RIMOC1 | RAB7A interacting MON1-CCZ1 complex subunit 1 | INVOLVED IN mitophagy (inferred); FOUND IN cytosol (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 7 | name | gene, protein-coding, MODEL [RefSeq] |