| 1305922 | Ptprb | protein tyrosine phosphatase, receptor type, B | ENCODES a protein that exhibits cadherin binding (ortholog); protein tyrosine phosphatase activity (ortholog); transmembrane receptor protein tyrosine kinase inhibitor activity (ortholog); INVOLVED IN glial cell migration; angiogenesis (ortholog); dephosphorylation (ortholog); ASSOCIATED WITH angios arcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN receptor complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol | 7 | 53816197 | 53920760 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314242 | PTPRB | protein tyrosine phosphatase receptor type B | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellula r domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] | 12 | 70515870 | 70637429 | Human | 144 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552328 | Ptprb | protein tyrosine phosphatase receptor type B | Predicted to enable cadherin binding activity. Involved in angiogenesis and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Predicted to be located in membrane. Predicted to be part of receptor complex. Is expressed in several structures, including cardiovasc ular system; central nervous system; embryo mesenchyme; genitourinary system; and umbilical artery. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 116111407 | 116225443 | Mouse | 163 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8958963 | Ptprb | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (ortholog); protein tyrosine phosphatase activity (ortholog); transmembrane receptor protein tyrosine kinase inhibitor activity (ortholog); INVOLVED IN angiogenesis (ortholog); dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN receptor complex (ortholog) | NW_004955405 | 10647777 | 10766909 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11695335 | PTPRB | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (inferred); hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN membrane (inferred); receptor complex (inferred) | 12 | 68025973 | 68147613 | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12157623 | PTPRB | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (inferred); hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN membrane (inferred); receptor complex (inferred) | 10 | 12267891 | 12384522 | Dog | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12707670 | Ptprb | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (inferred); hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN membrane (inferred); receptor complex (inferred) | NW_004936545 | 8150766 | 8235674 | Squirrel | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626100801 | Ptprb | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (ortholog); protein tyrosine phosphatase activity (ortholog); transmembrane receptor protein tyrosine kinase inhibitor activity (ortholog); INVOLVED IN angiogenesis (ortholog); dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN receptor complex (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14288730 | PTPRB | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (inferred); hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN membrane (inferred); receptor complex (inferred) | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913637 | Ptprb | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits transmembrane receptor protein tyrosine kinase inhibitor activity (ortholog); INVOLVED IN dephosphorylation (ortholog); glial cell migration (ortholog); osteoblast differentiation (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast ang iosarcoma (ortholog); FOUND IN membrane (inferred); receptor complex (inferred) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237992 | ptprb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18339765 | PTPRB | protein tyrosine phosphatase receptor type B | ENCODES a protein that exhibits cadherin binding (inferred); hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); glial cell migration (ortholog); ASSOCIATED WITH angiosarcoma (ortholog); brain glioma (ortholog); breast angiosarcoma (ortholog); FOUND IN membrane (inferred); receptor complex (inferred) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237993 | ptprb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405855964 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626178726 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861989 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861508 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862458 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183432 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180319 | ptprb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38648635 | PTPRB-AS1 | PTPRB antisense RNA 1 | | 12 | 70468079 | 70571450 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, MODEL [RefSeq] |
| 16561561 | AC025569.1 | novel transcript, antisense to PTPRB | | | | | Human | | name | gene, lncrna |
| 16568147 | AC083809.1 | novel transcript, antisense to PTPRB | | | | | Human | | name | gene, lncrna |
| 735532 | PTPRG | protein tyrosine phosphatase receptor type G | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellul ar region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008] | 3 | 61561571 | 62297609 | Human | 157 | description | gene, protein-coding, REVIEWED [RefSeq] |
