| 3447 | Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | ENCODES a protein that exhibits cell adhesion molecule binding; D1 dopamine receptor binding; insulin receptor binding; INVOLVED IN cellular response to angiotensin; cellular response to hydrogen peroxide; cellular response to insulin-like growth factor stimulus; PARTICIPATES IN insulin signaling pa thway; somatostatin signaling pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Carotid Artery Injuries; Fetal Growth Retardation; glaucoma; FOUND IN plasma membrane raft; protein-containing complex; cytoplasm (ortholog); INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether | 12 | 41026079 | 41085577 | Rat | 528 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731746 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016] | 12 | 112418947 | 112509918 | Human | 1670 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731747 | Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of lipopolysaccharide-mediated signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Used to study several diseases, including Noonan syndrome 1; hepatocellular adenoma; idiopathic scoliosis; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 121268596 | 121329460 | Mouse | 932 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8703700 | Ptpn11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cadherin binding (ortholog); cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); INVOLVED IN atrioventricular canal development (ortholog); axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); PARTICIPATES IN epiderm al growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); focal adhesion (ortholog) | NW_004955482 | 8934734 | 9031230 | Chinchilla | 354 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11949981 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN e pidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); plasma membrane raft (ortholog) | 12 | 110016364 | 110107462 | Bonobo | 360 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12326459 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN e pidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane raft (ortholog); protein-containing complex (ortholog) | 26 | 9989218 | 10072245 | Dog | 357 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12726557 | Ptpn11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN e pidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane raft (ortholog); protein-containing complex (ortholog) | NW_004936668 | 2602261 | 2687903 | Squirrel | 357 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13937253 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN e pidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane raft (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 359 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18705763 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN e pidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane raft (ortholog); protein-containing complex (ortholog) | | | | Green Monkey | 361 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934742 | Ptpn11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cadherin binding (ortholog); cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); INVOLVED IN atrioventricular canal development (ortholog); axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); PARTICIPATES IN epiderm al growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN cytosol (ortholog); focal adhesion (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 349 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626013178 | Ptpn11 | protein tyrosine phosphatase non-receptor type 11 | ENCODES a protein that exhibits cadherin binding (ortholog); cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); INVOLVED IN atrioventricular canal development (ortholog); axonogenesis (ortholog); Bergmann glial cell differentiation (ortholog); PARTICIPATES IN epiderm al growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); focal adhesion (ortholog) | | | | Black Rat | 322 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626172531 | ptpn11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626175620 | ptpn11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626183150 | ptpn11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 5131970 | Ptpn11em1Mcwi | protein tyrosine phosphatase, non-receptor type 11; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 17-bp frameshift deletion in exon 4 (del 624-640). | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 5131969 | Ptpn11em4Mcwi | protein tyrosine phosphatase, non-receptor type 11; zinc finger nuclease induced mutant 4, Medical College of Wisconsin | This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 84-bp frameshift deletion in exon 4 (del 570-653). | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 38619125 | PTPN11P1 | PTPN11 pseudogene 1 | | 3 | 107105314 | 107107165 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38611813 | PTPN11P2 | PTPN11 pseudogene 2 | | 8 | 58424993 | 58426850 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38644343 | PTPN11P3 | PTPN11 pseudogene 3 | | 6 | 137705823 | 137707220 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38606284 | PTPN11P4 | PTPN11 pseudogene 4 | | 5 | 23303963 | 23305309 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38672731 | PTPN11P5 | PTPN11 pseudogene 5 | | 4 | 82580519 | 82581384 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16558048 | AC067942.2 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558711 | AC009927.1 | protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558830 | AC010460.3 | protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16557237 | AC074043.1 | protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552440 | AL356234.1 | protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 285608140 | ptpn11b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 407570668 | PTPN11BP | protein tyrosine phosphatase non-receptor type 11B, pseudogene | | | | | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo |
| 287047975 | ptpn11b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288057300 | ptpn11b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6893232 | LINC00673 | long intergenic non-protein coding RNA 673 | This gene produces a long non-protein coding RNA that is involved in the regulation of gene expression during tumor progression. This transcript can promote cell proliferation in gastric cancer through interaction with enhancer of zeste 2 and other epigenetic suppressors of gene expression, thereby downregulating target genes including Kruppel like factors 2 and 4. This transcript may also act as a tumor suppressor by promoting interaction between protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) and ubiquitin ligase, resulting in degradation of Ptpn11 and lowered oncogenic signalling. Naturally-occurring variation at this locus results in the formation of a binding site for miR-1231, which negatively regulates activity of this transcript. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017] | 17 | 72403322 | 72592804 | Human | 22 | description | gene, ncrna, REVIEWED [RefSeq] |
