| 3429 | Psme1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); regulation of proteasomal protein catabolic process (ortholog); PARTICIPATES IN antigen processing and presentation pathway; ubiquitin/proteas ome degradation pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN proteasome activator complex (inferred); proteasome complex (inferred); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 33038962 | 33041849 | Rat | 161 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733032 | PSME1 | proteasome activator subunit 1 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. T he 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] | 14 | 24136194 | 24138962 | Human | 171 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735503 | Psme1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including adipose tissu e; alimentary system; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human PSME1 (proteasome activator subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55815951 | 55818984 | Mouse | 162 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8758854 | Psme1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); regulation of proteasomal protein catabolic process (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); eso phagus squamous cell carcinoma (ortholog); FOUND IN proteasome complex (ortholog) | NW_004955409 | 36262114 | 36264996 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11817292 | PSME1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (i nferred); nucleoplasm (inferred); proteasome activator complex (inferred) | 14 | 4912390 | 4915219 | Bonobo | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12189373 | PSME1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN proteasome a ctivator complex (inferred); proteasome complex (inferred) | 8 | 4131197 | 4134001 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12595179 | Psme1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (i nferred); nucleoplasm (inferred); proteasome activator complex (inferred) | NW_004936722 | 405491 | 408277 | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14241312 | PSME1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN proteasome a ctivator complex (inferred); proteasome complex (inferred) | | | | Pig | 18 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626075274 | Psme1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); regulation of proteasomal protein catabolic process (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); eso phagus squamous cell carcinoma (ortholog); FOUND IN proteasome complex (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248228 | psme1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18524533 | PSME1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (i nferred); nucleoplasm (inferred); proteasome activator complex (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917023 | Psme1 | proteasome activator subunit 1 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytoplasm (i nferred); nucleoplasm (inferred); proteasome activator complex (inferred) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248343 | psme1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252433 | psme1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1597686 | Psme1-ps1 | proteasome activator subunit 1, pseudogene 1 | FOUND IN proteasome activator complex (inferred); proteasome complex (inferred); INTERACTS WITH 6-propyl-2-thiouracil; tetrachloromethane | 17 | 54869662 | 54870652 | Rat | 9 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15038666 | Psme1-ps1 | protease (prosome, macropain) 28 subunit, alpha, pseudogene 1 | | | | | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo |
| 2323882 | Psme1-ps2 | proteasome activator subunit 1, pseudogene 2 | | 9 | 34790912 | 34792162 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1593823 | Psme1l1 | proteasome activator subunit 1 like 1 | | 17 | 59992882 | 59993668 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
