| 61881 | Psmb6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of pr oteasomal protein catabolic process (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 55737852 | 55740218 | Rat | 157 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 62173 | Psmb6 | proteasome (prosome, macropain) subunit, beta type 6 | Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in seminiferous cord. Orthologous to human PSMB6 (proteasome 20S subunit beta 6). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 70416116 | 70418684 | Mouse | 170 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1349289 | PSMB6 | proteasome 20S subunit beta 6 | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throug hout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] | 17 | 4796164 | 4798495 | Human | 183 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8703164 | Psmb6 | proteasome 20S subunit beta 6 | INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of proteasomal protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955467 | 10220435 | 10222470 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11946021 | PSMB6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis (inf erred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 17 | 4842978 | 4845321 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12398216 | PSMB6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis (inf erred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 5 | 31776286 | 31778789 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12567637 | Psmb6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of pr oteasomal protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004936677 | 2893780 | 2895870 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18702017 | PSMB6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); proteolysis (inf erred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14219064 | PSMB6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of pr oteasomal protein catabolic process (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 26 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18935778 | Psmb6 | proteasome 20S subunit beta 6 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of pr oteasomal protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625981323 | Psmb6 | proteasome 20S subunit beta 6 | INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); regulation of proteasomal protein catabolic process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249857 | psmb6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155248610 | psmb6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249856 | psmb6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2306594 | Psmb6-ps | proteasome (prosome, macropain) subunit, beta type 6, pseudogene | | X | 7816390 | 7817104 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1562774 | Psmb6-ps1 | proteasome 20S subunit beta 6, pseudogene 1 | | 1 | 233459203 | 233460683 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1584113 | Psmb6-ps2 | proteasome 20S subunit beta 6, pseudogene 2 | | X | 35578117 | 35581889 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2306591 | Psmb6-ps2 | proteasome (prosome, macropain) subunit, beta type 6, pseudogene 2 | | 1 | 101313575 | 101314388 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 12583877 | LOC101974062 | proteasome subunit beta type-6-like | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); proteolysis involved in protein catabolic process (inferred); FOUND IN cytoplasm (inferred); nucleus (inferred); proteas ome complex (inferred) | NW_004936487 | 16433848 | 16435713 | Squirrel | 13 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 2321312 | Psmb6l1 | proteasome 20S subunit beta 6 like 1 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); proteolysis involved in protein catabolic process (inferred); FOUND IN cytoplasm (inferred); nucleus (inferred); proteas ome complex (inferred) | 2 | 95741230 | 95741946 | Rat | 16 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 737219 | PSMB9 | proteasome 20S subunit beta 9 | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throug hout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010] | 6 | 32854192 | 32859851 | Human | 301 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2291820 | PSMB11 | proteasome subunit beta 11 | Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008] | 14 | 23042212 | 23044060 | Human | 50 | description | gene, protein-coding, VALIDATED [RefSeq] |