| 1309969 | Prr5l | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); negative regulation of protein phosphorylation (ortholog); positive regulation of intracellular protein transport (ortholog); PARTICIPATES IN mTOR signaling path way; FOUND IN TORC2 complex (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; bis(2-chloroethyl) sulfide; bisphenol A | 3 | 108458107 | 108628552 | Rat | 135 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320600 | Prr5l | proline rich 5 like | Predicted to enable ubiquitin protein ligase binding activity. Involved in TORC2 signaling and regulation of fibroblast migration. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Located in mitochondrion. Is expressed in cranium; genitourinary system; jaw; and limb. Orthologous to human PRR5L (proline rich 5 like). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 101543455 | 101713428 | Mouse | 132 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605618 | PRR5L | proline rich 5 like | Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; regulation of fibroblast migration; and regulation of primary metabolic process. Part of TORC2 complex. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 36296288 | 36465204 | Human | 119 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8723191 | Prr5l | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); negative regulation of protein phosphorylation (ortholog); positive regulation of intracellular protein transport (ortholog); PARTICIPATES IN mTOR signaling path way; FOUND IN TORC2 complex (ortholog) | NW_004955422 | 9972588 | 10069411 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11672562 | PRR5L | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); positive regulation of protein phosphorylation (or tholog); PARTICIPATES IN mTOR signaling pathway; FOUND IN TORC2 complex (inferred) | 11 | 36269291 | 36438954 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12091520 | PRR5L | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); positive regulation of protein phosphorylation (or tholog); PARTICIPATES IN mTOR signaling pathway; FOUND IN TORC2 complex (inferred) | 18 | 31708888 | 31849365 | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12450148 | Prr5l | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); positive regulation of protein phosphorylation (or tholog); PARTICIPATES IN mTOR signaling pathway; FOUND IN TORC2 complex (inferred) | NW_004936533 | 1895594 | 1975442 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18525164 | PRR5L | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); positive regulation of protein phosphorylation (or tholog); PARTICIPATES IN mTOR signaling pathway; FOUND IN TORC2 complex (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626067691 | Prr5l | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); negative regulation of protein phosphorylation (ortholog); positive regulation of intracellular protein transport (ortholog); PARTICIPATES IN mTOR signaling path way; FOUND IN TORC2 complex (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900641 | Prr5l | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); positive regulation of protein phosphorylation (or tholog); PARTICIPATES IN mTOR signaling pathway; FOUND IN TORC2 complex (inferred) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13918796 | PRR5L | proline rich 5 like | ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); positive regulation of protein phosphorylation (or tholog); PARTICIPATES IN mTOR signaling pathway; FOUND IN TORC2 complex (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285311833 | prr5l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 288083096 | prr5l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284880124 | prr5l.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2299112 | Prr5lTn(sb-T2/Bart3)2.228Mcwi | proline rich 5 like; transposon insertion 2.228, Medical College of Wisconsin | This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Prr5l gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
