| 621526 | Ppp1r15a | protein phosphatase 1, regulatory subunit 15A | ENCODES a protein that exhibits protein phosphatase 1 binding; eukaryotic initiation factor eIF2 binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN cellular response to antibiotic; cellular response to calcium ion starvation; cellular response to carbohydrate stimulus; PARTICIPAT ES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH brain ischemia; Emphysema; Spinal Cord Injuries; FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog); INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 105136521 | 105139596 | Rat | 447 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732704 | Ppp1r15a | protein phosphatase 1, regulatory subunit 15A | Enables protein phosphatase binding activity and protein phosphatase regulator activity. Involved in positive regulation of signal transduction by p53 class mediator; regulation of gene expression; and response to endoplasmic reticulum stress. Acts upstream of or within endoplasmic reticulum unfolde d protein response. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and hemolymphoid system gland. Used to study thalassemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 45172341 | 45175692 | Mouse | 477 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1342864 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is cor related with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008] | 19 | 48872421 | 48876058 | Human | 456 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9004368 | Ppp1r15a | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits eukaryotic initiation factor eIF2 binding (ortholog); molecular adaptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohy drate stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | NW_004955559 | 1750227 | 1753607 | Chinchilla | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11800854 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN Bon e morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN endoplasmic reticulum (ortholog); protein phosphatase type 1 complex (ortholog) | 19 | 45872596 | 45876376 | Bonobo | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12346026 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN Bon e morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN protein phosphatase type 1 complex (ortholog) | 1 | 107486399 | 107490151 | Dog | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12667292 | Ppp1r15a | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits eukaryotic initiation factor eIF2 binding (ortholog); molecular adaptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohy drate stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | NW_004936664 | 2910609 | 2914205 | Squirrel | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865866 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | | | | | Green Monkey | | symbol | gene, protein-coding |
| 625845481 | Ppp1r15a | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits eukaryotic initiation factor eIF2 binding (ortholog); molecular adaptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohy drate stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13879752 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN Bon e morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN protein phosphatase type 1 complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40893774 | PPP1R15A | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits protein phosphatase 1 binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN Bon e morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN endoplasmic reticulum (ortholog); protein phosphatase type 1 complex (ortholog) | | | | Green Monkey | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905191 | Ppp1r15a | protein phosphatase 1 regulatory subunit 15A | ENCODES a protein that exhibits eukaryotic initiation factor eIF2 binding (ortholog); molecular adaptor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion starvation (ortholog); cellular response to carbohy drate stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Amaurosis Fugax (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |