| 1305220 | Ppm1l | protein phosphatase, Mg2+/Mn2+ dependent, 1L | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetr achlorodibenzodioxine; acetamide | 2 | 155876605 | 156149371 | Rat | 113 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313118 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] | 3 | 160756231 | 161078902 | Human | 124 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313119 | Ppm1l | protein phosphatase 1 (formerly 2C)-like | Enables protein serine/threonine phosphatase activity. Acts upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including gut; limb segment; metanephros; nervous syste m; and sensory organ. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 69224251 | 69468131 | Mouse | 141 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8815608 | Ppm1l | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog) | NW_004955448 | 11265988 | 11548258 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11842953 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits cation binding (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); FOUND IN membrane (infe rred) | 3 | 157775284 | 158093293 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12249784 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits cation binding (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); FOUND IN membrane (infe rred) | 34 | 26770442 | 27060892 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12645462 | Ppm1l | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits cation binding (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); FOUND IN membrane (infe rred) | NW_004936708 | 724878 | 1006405 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18681605 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); FO UND IN membrane (inferred) | | | | Green Monkey | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625837036 | Ppm1l | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13946445 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits cation binding (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); FOUND IN membrane (infe rred) | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242199 | ppm1l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18922668 | Ppm1l | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits cation binding (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog); FOUND IN membrane (infe rred) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866859 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); phosphoprotein phosphatase activity (inferred); FOUND IN membrane (inferred) | | | | Green Monkey | 8 | symbol | gene, protein-coding |
| 155255864 | ppm1l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242200 | ppm1l.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 40903027 | PPM1L-DT | PPM1L divergent transcript | | 3 | 160750785 | 160755451 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
