| 620237 | Ppat | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity; identical protein binding; INVOLVED IN animal organ regeneration; cellular response to insulin stimulus; cellular response to xenobiotic stimulus; PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransfe rase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; hepatocellular carcinoma; renal cell carcinoma; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 14 | 31570010 | 31604410 | Rat | 177 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733613 | PPAT | phosphoribosyl pyrophosphate amidotransferase | The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and s even of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011] | 4 | 56393362 | 56435615 | Human | 174 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736394 | Ppat | phosphoribosyl pyrophosphate amidotransferase | Enables amidophosphoribosyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Is expressed in several structures, including alimentary system; brain; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human PPAT t-weight:700;'>PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 77061096 | 77099425 | Mouse | 182 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8843586 | Ppat | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN 'de novo' AMP biosynthetic process (ortholog); 'de novo' IMP biosynthetic process (ortholog); 'de novo' XMP biosynthetic process (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | NW_004955447 | 14552846 | 14607416 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11757307 | PPAT | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN 'de novo' AMP biosynthetic process (ortholog); 'de novo' XMP biosynthetic process (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | 4 | 67491407 | 67533822 | Bonobo | 52 | symbol , Ensembl Transcript | gene, protein-coding, MODEL [RefSeq] |
| 12232033 | PPAT | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to insulin stimulus (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | 13 | 48618460 | 48656164 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12478776 | Ppat | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to insulin stimulus (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | NW_004936482 | 18606124 | 18648989 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234395 | ppat | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14276287 | PPAT | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to insulin stimulus (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog); INTERACTS WITH deoxynivalenol; resveratrol | | | | Pig | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626108013 | Ppat | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN 'de novo' AMP biosynthetic process (ortholog); 'de novo' IMP biosynthetic process (ortholog); 'de novo' XMP biosynthetic process (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18665850 | PPAT | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to insulin stimulus (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | | | | Green Monkey | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902504 | Ppat | phosphoribosyl pyrophosphate amidotransferase | ENCODES a protein that exhibits amidophosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN 'de novo' AMP biosynthetic process (ortholog); 'de novo' IMP biosynthetic process (ortholog); 'de novo' XMP biosynthetic process (ortholog); PARTICIPATES IN 2-hydroxy glutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Experimental Liver Neoplasms (ortholog); hepatocellular carcinoma (ortholog) | | | | Naked Mole-Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14375196 | ppat-1 | | | | | | Roundworm | | symbol | gene, null |
| 155259447 | ppat.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254564 | ppat.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14371501 | Ppat-Dpck | | | | | | Fly | | symbol | gene, null |
| 1354088 | COASY | Coenzyme A synthase | Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene e ncodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014] | 17 | 42562148 | 42566277 | Human | 208 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1558125 | Coasy | Coenzyme A synthase | This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015] | 11 | 100973391 | 100977445 | Mouse | 154 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14154023 | COASY | Coenzyme A synthase | ENCODES a protein that exhibits dephospho-CoA kinase activity; pantetheine-phosphate adenylyltransferase activity; INVOLVED IN coenzyme A biosynthetic process (ortholog); PARTICIPATES IN pantothenic acid metabolic pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness 3 (ortholog); mucop olysaccharidosis III (ortholog); Myopathy with Abnormal Lipid Metabolism (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog) | | | | Pig | 46 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1348767 | PPATP1 | phosphoribosyl pyrophosphate amidotransferase pseudogene 1 | | 3 | 87050995 | 87052869 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7246747 | PPATP2 | phosphoribosyl pyrophosphate amidotransferase pseudogene 2 | | X | 78699384 | 78699887 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |