| 620822 | Polr1b | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity; DNA/RNA hybrid binding (ortholog); zinc ion binding (ortholog); INVOLVED IN rRNA transcription; embryo implantation (ortholog); neural crest formation (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; purine meta bolic pathway; pyrimidine metabolic pathway; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treacher Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex; chromosome (ortholog); fibrillar center (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 3 | 136787130 | 136811608 | Rat | 157 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731265 | Polr1b | polymerase (RNA) I polypeptide B | Predicted to enable DNA/RNA hybrid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Acts upstream of or within embryo implantation; nucleologenesis; and rRNA transcription. Located in chromosome and nucleolus. Part of RNA polymerase I c omplex. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 128942891 | 128969980 | Mouse | 170 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348858 | POLR1B | RNA polymerase I subunit B | Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008] | 2 | 112542036 | 112579818 | Human | 232 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8765317 | Polr1b | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); DNA/RNA hybrid binding (ortholog); zinc ion binding (ortholog); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathw ay; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treacher Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN chromosome (ortholog); fibrillar center (ortholog); nucleolus (ortholog) | NW_004955470 | 1714156 | 1737749 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11936102 | POLR1B | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treac her Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex (ortholog) | 2A | 89478133 | 89516559 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12147254 | POLR1B | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA binding (inferred); DNA-directed RNA polymerase activity (inferred); DNA/RNA hybrid binding (inferred); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; A SSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treacher Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex (ortholog); INTERACTS WITH bisphenol A | 17 | 36774472 | 36798900 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12488519 | Polr1b | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treac her Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex (ortholog) | NW_004936783 | 1034097 | 1055798 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14241221 | POLR1B | RNA polymerase I subunit B | ENCODES a protein that exhibits 5'-3' RNA polymerase activity (inferred); DNA binding (inferred); DNA-directed RNA polymerase activity (inferred); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pat hway; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treacher Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625844124 | Polr1b | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); DNA/RNA hybrid binding (ortholog); zinc ion binding (ortholog); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathw ay; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treacher Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN chromosome (ortholog); fibrillar center (ortholog); nucleolus (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919695 | Polr1b | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treac her Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex (ortholog) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18695809 | POLR1B | RNA polymerase I subunit B | ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); INVOLVED IN embryo implantation (ortholog); nucleologenesis (ortholog); rRNA transcription (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; ASSOCIATED WITH Mandibulofacial Dysostosis (ortholog); Treac her Collins syndrome (ortholog); Treacher Collins syndrome 4 (ortholog); FOUND IN RNA polymerase I complex (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235756 | polr1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155235755 | polr1b.L | | | | | | African Clawed Frog | | symbol | gene, null |