| 3361 | Pnmt | phenylethanolamine-N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity; INVOLVED IN adrenal gland development; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; PARTICIPATES IN epinephrine biosynthetic pathway; alkaptonuria pathway; aromatic L-amino a cid decarboxylase deficiency pathway; ASSOCIATED WITH Contusions; Experimental Diabetes Mellitus; hypertension; FOUND IN axon; dendrite; neuronal cell body; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 10 | 83881211 | 83882849 | Rat | 118 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11126 | Pnmt | phenylethanolamine-N-methyltransferase | Enables phenylethanolamine N-methyltransferase activity. Predicted to be involved in epinephrine biosynthetic process and norepinephrine metabolic process. Predicted to be located in axon; dendrite; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including adre nal gland; brain; gonad; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 98277449 | 98279006 | Mouse | 126 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 732850 | PNMT | phenylethanolamine N-methyltransferase | The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production . Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] | 17 | 39668019 | 39670475 | Human | 110 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9038745 | Pnmt | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | NW_004955451 | 14414836 | 14417972 | Chinchilla | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11916614 | PNMT | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | 17 | 17618399 | 17620691 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12236185 | PNMT | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | 9 | 22808505 | 22810587 | Dog | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12692275 | Pnmt | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | NW_004936490 | 14858682 | 14861614 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18580105 | PNMT | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235092 | pnmt | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14133989 | PNMT | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | | | | Pig | 58 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625846900 | Pnmt | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | | | | Black Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913368 | Pnmt | phenylethanolamine N-methyltransferase | ENCODES a protein that exhibits phenylethanolamine N-methyltransferase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Contusions (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234574 | pnmt.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235091 | pnmt.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 732310 | PEMT | phosphatidylethanolamine N-methyltransferase | Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidy lcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012] | 17 | 17505563 | 17592142 | Human | 190 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |