| 628867 | Pla2g6 | phospholipase A2 group VI | ENCODES a protein that exhibits A2-type glycerophospholipase activity; ATP-dependent protein binding; long-chain fatty acyl-CoA hydrolase activity; INVOLVED IN cardiolipin acyl-chain remodeling; maternal process involved in female pregnancy; memory; PARTICIPATES IN angiotensin II signaling pathway; alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Binge Drinking; Metabolic Syndrome; pleurisy; FOUND IN extracellular space (ortholog); mitochondrion (ortholog); plasma membrane (ortholog); INTERACTS WITH (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 112731803 | 112771978 | Rat | 238 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732454 | PLA2G6 | phospholipase A2 group VI | The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and tra nsmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010] | 22 | 38111495 | 38181830 | Human | 722 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732455 | Pla2g6 | phospholipase A2, group VI | Enables calcium-independent phospholipase A2 activity; long-chain fatty acyl-CoA hydrolase activity; and serine hydrolase activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in several cellular components, includin g extracellular space; microtubule cytoskeleton; and nuclear speck. Predicted to be active in mitochondrion. Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Used to study Parkinson's disease 14 and neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 79170428 | 79212915 | Mouse | 335 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9063130 | Pla2g6 | phospholipase A2 group VI | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); ATP-dependent protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN antibacterial humoral response (ortholog); cardiolipin acyl-chain remodeling (ortholog); maternal process involved in female p regnancy (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN extracellular space (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | NW_004955413 | 24431592 | 24482229 | Chinchilla | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11904129 | PLA2G6 | phospholipase A2 group VI | ENCODES a protein that exhibits ATP-dependent protein binding (ortholog); obsolete calcium-independent phospholipase A2 activity (ortholog); protein kinase binding (ortholog); INVOLVED IN maternal process involved in female pregnancy (ortholog); memory (ortholog); negative regulation of synaptic tra nsmission, glutamatergic (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN anchoring junction (inferred); cell-cell contact zone (inferred); clathrin complex (inferred) | 22 | 18998060 | 19094507 | Bonobo | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12300923 | PLA2G6 | phospholipase A2 group VI | ENCODES a protein that exhibits ATP-dependent protein binding (ortholog); obsolete calcium-independent phospholipase A2 activity (ortholog); protein kinase binding (ortholog); INVOLVED IN maternal process involved in female pregnancy (ortholog); memory (ortholog); negative regulation of synaptic tra nsmission, glutamatergic (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH neurodegeneration with brain iron accumulation; autistic disorder (ortholog); Binge Drinking (ortholog); FOUND IN cytoplasm (inferred); extracellular space (inferred); mitochondrion (inferred) | 10 | 26499033 | 26559533 | Dog | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12511688 | Pla2g6 | phospholipase A2 group VI | ENCODES a protein that exhibits ATP-dependent protein binding (ortholog); obsolete calcium-independent phospholipase A2 activity (ortholog); protein kinase binding (ortholog); INVOLVED IN maternal process involved in female pregnancy (ortholog); memory (ortholog); negative regulation of synaptic tra nsmission, glutamatergic (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN cytoplasm (inferred); extracellular space (inferred); mitochondrion (inferred) | NW_004936492 | 3011752 | 3060962 | Squirrel | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625849204 | Pla2g6 | phospholipase A2 group VI | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); ATP-dependent protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN antibacterial humoral response (ortholog); cardiolipin acyl-chain remodeling (ortholog); maternal process involved in female p regnancy (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN extracellular space (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | | | | Black Rat | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900033 | Pla2g6 | phospholipase A2 group VI | ENCODES a protein that exhibits ATP-dependent protein binding (ortholog); obsolete calcium-independent phospholipase A2 activity (ortholog); protein kinase binding (ortholog); INVOLVED IN maternal process involved in female pregnancy (ortholog); memory (ortholog); negative regulation of synaptic tra nsmission, glutamatergic (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN cytoplasm (inferred); extracellular space (inferred); mitochondrion (inferred) | | | | Naked Mole-Rat | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866283 | PLA2G6 | phospholipase A2 group VI | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN antibacterial humoral response (inferred); cardiolipin acyl-chain remodeling (inferred); phosphatidylcholine catabolic process (inferred) ; FOUND IN extracellular space (inferred); mitochondrion (inferred); plasma membrane (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding |
| 18784733 | PLA2G6 | phospholipase A2 group VI | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); ATP-dependent protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN antibacterial humoral response (ortholog); cardiolipin acyl-chain remodeling (ortholog); maternal process involved in female p regnancy (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN extracellular space (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239755 | pla2g6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13939780 | PLA2G6 | phospholipase A2 group VI | ENCODES a protein that exhibits ATP-dependent protein binding (ortholog); obsolete calcium-independent phospholipase A2 activity (ortholog); protein kinase binding (ortholog); INVOLVED IN maternal process involved in female pregnancy (ortholog); memory (ortholog); negative regulation of synaptic tra nsmission, glutamatergic (ortholog); PARTICIPATES IN angiotensin II signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Binge Drinking (ortholog); cerebellar hypoplasia (ortholog); FOUND IN cytoplasm (inferred); extracellular space (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250859 | pla2g6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243424 | pla2g6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16568865 | AL022322.2 | novel transcript, antisense to PLA2G6 | | | | | Human | | name | gene, lncrna |