| 11100 | Piga | phosphatidylinositol glycan anchor biosynthesis, class A | Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylin ositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in 1st branchial arch; central nervous system; heart; limb; and medial-nasal process. Used to study autosomal recessive congenital ichthyosis 4B. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Jul 2025] | X | 163202814 | 163216912 | Mouse | 231 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1589723 | Piga | phosphatidylinositol glycan anchor biosynthesis, class A | ENCODES a protein that exhibits glycosyltransferase activity (inferred); phosphatidylinositol N-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); PART ICIPATES IN glycosylphosphatidylinositol anchor biosynthetic pathway; ASSOCIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (ortholog); INTERACTS WITH 1,3-Propane sultone; 1,4-phenylenediamine; 2,3,7,8-tetrachlorodibenzodioxine | X | 33672832 | 33687747 | Rat | 179 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1607087 | PIGA | phosphatidylinositol glycan anchor biosynthesis class A | This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010] | X | 15319451 | 15335554 | Human | 527 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8767103 | Piga | phosphatidylinositol glycan anchor biosynthesis class A | INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSOCIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) ; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (ortholog) | NW_004955519 | 2852605 | 2865848 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11972757 | PIGA | phosphatidylinositol glycan anchor biosynthesis class A | ENCODES a protein that exhibits glycosyltransferase activity (inferred); phosphatidylinositol N-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSO CIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (inferred) | X | 7946158 | 7962320 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12254691 | PIGA | phosphatidylinositol glycan anchor biosynthesis class A | INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSOCIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) ; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (ortholog) | X | 11570327 | 11583401 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12459674 | Piga | phosphatidylinositol glycan anchor biosynthesis class A | ENCODES a protein that exhibits glycosyltransferase activity (inferred); phosphatidylinositol N-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSO CIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (inferred) | NW_004936470 | 4730955 | 4746958 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626035718 | Piga | phosphatidylinositol glycan anchor biosynthesis class A | INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSOCIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) ; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258927 | piga | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13981559 | PIGA | phosphatidylinositol glycan anchor biosynthesis class A | ENCODES a protein that exhibits glycosyltransferase activity (inferred); phosphatidylinositol N-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSO CIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (inferred); membrane (inferred) | | | | Pig | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901236 | Piga | phosphatidylinositol glycan anchor biosynthesis class A | ENCODES a protein that exhibits glycosyltransferase activity (inferred); phosphatidylinositol N-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSO CIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (inferred) | | | | Naked Mole-Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18492355 | PIGA | phosphatidylinositol glycan anchor biosynthesis class A | ENCODES a protein that exhibits glycosyltransferase activity (inferred); phosphatidylinositol N-acetylglucosaminyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); GPI anchor biosynthetic process (ortholog); ASSO CIATED WITH autosomal recessive congenital ichthyosis 4B (ortholog); generalized epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14386324 | piga-1 | | | | | | Roundworm | | symbol | gene, null |
| 155241611 | piga.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 41346119 | Piga-ps1 | phosphatidylinositol glycan anchor biosynthesis, class A, pseudogene 1 | | 8 | 54164198 | 54168062 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 3328 | Pigr | polymeric immunoglobulin receptor | ENCODES a protein that exhibits epidermal growth factor receptor binding; polymeric immunoglobulin binding (ortholog); polymeric immunoglobulin receptor activity (ortholog); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (ortholog); epidermal growth factor receptor signaling pathway (ortholog); Fc receptor signaling pathway (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH IgA glomerulonephritis (ortholog); Stomach Neoplasms (ortholog); FOUND IN recycling endosome membrane; extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol | 13 | 44851001 | 44879143 | Rat | 150 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16561432 | AC010200.1 | phosphatidylinositol glycan anchor biosynthesis, class A (PIGA) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1350762 | PIGAP1 | phosphatidylinositol glycan anchor biosynthesis class A pseudogene 1 | | 12 | 100578659 | 100582672 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |