| 1305052 | Pgs1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 10 | 103713306 | 103748924 | Rat | 88 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312851 | Pgs1 | phosphatidylglycerophosphate synthase 1 | Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and skin. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 117876505 | 117914837 | Mouse | 94 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606322 | PGS1 | phosphatidylglycerophosphate synthase 1 | Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity and calcium ion binding activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in endoplasmic reticulum. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 78378649 | 78424659 | Human | 93 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8903879 | Pgs1 | phosphatidylglycerophosphate synthase 1 | PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog) | NW_004955506 | 4160546 | 4203474 | Chinchilla | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11781584 | PGS1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); mitochondrial inner membrane (inferred) | 17 | 72455008 | 72501058 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12248166 | PGS1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); mitochondrial inner membrane (inferred) | 9 | 2808169 | 2845308 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12717922 | Pgs1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN endoplasmic reticulum (inferred); mitochondrial inner membrane (inferred); mitochondrion (inferred) | NW_004936594 | 2934450 | 2989328 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14381479 | PGS1 | | | | | | Yeast | | symbol | gene, null |
| 18643215 | PGS1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); mitochondrion (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625868065 | Pgs1 | phosphatidylglycerophosphate synthase 1 | PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog) | | | | Black Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14262716 | PGS1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); mitochondrial inner membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931114 | Pgs1 | phosphatidylglycerophosphate synthase 1 | ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (inferred); INVOLVED IN cardiolipin biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylglycerol biosynthetic process (inferred); PARTICIPATES IN cardiolipin biosynthetic pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH High Myopia (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241452 | pgs1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934443 | pgs1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935503 | pgs1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242263 | pgs1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934243 | pgs1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934640 | pgs1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259350 | pgs1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1323455 | TPGS1 | tubulin polyglutamylase complex subunit 1 | Predicted to enable microtubule binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including adult behavior; chemical synaptic transmission; and protein polyglutamylation. Located i n centrosome. [provided by Alliance of Genome Resources, Apr 2025] | 19 | 507497 | 519654 | Human | 65 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1323456 | Tpgs1 | tubulin polyglutamylase complex subunit 1 | Enables microtubule binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including adult behavior; protein polyglutamylation; and sperm axoneme assembly. Predicted to be located in centrosome and membrane. Predicted to be active in microtubule org anizing center. Orthologous to human TPGS1 (tubulin polyglutamylase complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 79505273 | 79511961 | Mouse | 78 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1588613 | Tpgs1 | tubulin polyglutamylase complex subunit 1 | ENCODES a protein that exhibits microtubule binding (ortholog); tubulin binding (ortholog); tubulin-glutamic acid ligase activity (ortholog); INVOLVED IN adult behavior (ortholog); chemical synaptic transmission (ortholog); protein polyglutamylation (ortholog); FOUND IN centrosome (ortholog); INTERA CTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; fenvalerate | 7 | 10680461 | 10686383 | Rat | 61 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |