Tpgs1 (tubulin polyglutamylase complex subunit 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tpgs1 (tubulin polyglutamylase complex subunit 1) Mus musculus
Analyze
Symbol: Tpgs1
Name: tubulin polyglutamylase complex subunit 1
RGD ID: 1323456
MGI Page MGI
Description: Enables microtubule binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including adult behavior; protein polyglutamylation; and sperm axoneme assembly. Predicted to be located in centrosome and membrane. Predicted to be active in microtubule organizing center. Orthologous to human TPGS1 (tubulin polyglutamylase complex subunit 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AV005629; gene trap ROSA b-geo 22; Gm16517; Gtrgeo; Gtrgeo22; p32; PGs1; PGs1 protein p32
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,505,273 - 79,511,961 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,505,203 - 79,511,961 (+)EnsemblGRCm39 Ensembl
GRCm381079,669,439 - 79,676,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,669,369 - 79,676,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,132,155 - 79,138,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,072,539 - 79,079,066 (+)NCBIMGSCv36mm8
Celera1080,683,145 - 80,689,861 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12242242   PMID:12466851   PMID:12477932   PMID:12904583   PMID:12972506   PMID:14610273   PMID:15890843  
PMID:16141072   PMID:16141073   PMID:17360631   PMID:17967808   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:29097665   PMID:37142655  


Genomics

Comparative Map Data
Tpgs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,505,273 - 79,511,961 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,505,203 - 79,511,961 (+)EnsemblGRCm39 Ensembl
GRCm381079,669,439 - 79,676,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,669,369 - 79,676,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,132,155 - 79,138,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,072,539 - 79,079,066 (+)NCBIMGSCv36mm8
Celera1080,683,145 - 80,689,861 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
TPGS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819507,497 - 519,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19507,497 - 519,654 (+)EnsemblGRCh38hg38GRCh38
GRCh3719507,497 - 519,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619458,497 - 470,654 (+)NCBINCBI36Build 36hg18NCBI36
Celera19297,964 - 310,121 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19277,653 - 289,928 (+)NCBIHuRef
CHM1_119507,000 - 518,651 (+)NCBICHM1_1
T2T-CHM13v2.019460,069 - 472,226 (+)NCBIT2T-CHM13v2.0
Tpgs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,680,461 - 10,686,383 (-)NCBIGRCr8
mRatBN7.2710,029,842 - 10,035,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,029,854 - 10,035,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,910,831 - 12,916,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,788,910 - 14,794,812 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,648,201 - 12,654,116 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,912,251 - 12,918,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,912,263 - 12,918,173 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,080,966 - 13,086,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,546,760 - 11,552,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera78,203,089 - 8,209,005 (-)NCBICelera
Cytogenetic Map7q11NCBI
Tpgs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,181,907 - 7,189,726 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,181,907 - 7,189,726 (-)NCBIChiLan1.0ChiLan1.0
TPGS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,836,574 - 4,847,852 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,075,184 - 4,087,405 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019614,279 - 625,715 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TPGS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,971,465 - 57,977,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,971,704 - 57,977,486 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,774,240 - 57,780,320 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,715,047 - 58,721,138 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,712,782 - 58,721,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,768,615 - 57,774,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,248,466 - 58,254,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,451,731 - 58,457,810 (-)NCBIUU_Cfam_GSD_1.0
Tpgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,679,298 - 217,684,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588150,486 - 156,519 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588150,465 - 155,485 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPGS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,776,277 - 77,783,416 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,776,269 - 77,783,434 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TPGS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16236,753 - 248,531 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6237,462 - 248,526 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,843,203 - 8,888,590 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpgs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,946,301 - 7,953,653 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,946,158 - 7,953,633 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpgs1
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:137
Interacting mature miRNAs:143
Transcripts:ENSMUST00000020552
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
AV211525  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381079,668,365 - 79,668,494UniSTSGRCm38
MGSCv371079,131,110 - 79,131,239UniSTSGRCm37
Celera1080,682,100 - 80,682,229UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map10C1-C2UniSTS
cM Map1043.0UniSTS
Whitehead/MRC_RH10911.82UniSTS
Whitehead/MRC_RH10911.23UniSTS
UniSTS:236395  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381079,675,909 - 79,676,057UniSTSGRCm38
MGSCv371079,138,654 - 79,138,802UniSTSGRCm37
Celera1080,689,644 - 80,689,792UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
AV005629  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381079,675,906 - 79,676,022UniSTSGRCm38
MGSCv371079,138,651 - 79,138,767UniSTSGRCm37
Celera1080,689,641 - 80,689,757UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Madcam1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381079,667,601 - 79,667,815UniSTSGRCm38
MGSCv371079,130,346 - 79,130,560UniSTSGRCm37
Celera1080,681,336 - 80,681,550UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map10C1-C2UniSTS
cM Map1043.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000020552   ⟹   ENSMUSP00000020552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,505,203 - 79,511,961 (+)Ensembl
GRCm38.p6 Ensembl1079,669,369 - 79,676,127 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,505,717 - 79,511,432 (+)Ensembl
GRCm38.p6 Ensembl1079,669,883 - 79,675,598 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,505,747 - 79,511,282 (+)Ensembl
GRCm38.p6 Ensembl1079,669,913 - 79,675,448 (+)Ensembl
Ensembl Acc Id: ENSMUST00000239401   ⟹   ENSMUSP00000159326
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,505,244 - 79,511,960 (+)Ensembl
GRCm38.p6 Ensembl1079,669,410 - 79,676,126 (+)Ensembl
RefSeq Acc Id: NM_148934   ⟹   NP_683736
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,505,273 - 79,511,961 (+)NCBI
GRCm381079,669,439 - 79,676,127 (+)NCBI
MGSCv371079,132,155 - 79,138,871 (+)RGD
Celera1080,683,145 - 80,689,861 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_683736   ⟸   NM_148934
- UniProtKB: Q9R0B5 (UniProtKB/Swiss-Prot),   Q99MS8 (UniProtKB/Swiss-Prot),   Q3U5Q9 (UniProtKB/Swiss-Prot),   A0A6Q6PKE1 (UniProtKB/TrEMBL),   B2RRP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000159326   ⟸   ENSMUST00000239401
Ensembl Acc Id: ENSMUSP00000020552   ⟸   ENSMUST00000020552

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MS8-F1-model_v2 AlphaFold Q99MS8 1-303 view protein structure

Promoters
RGD ID:6819339
Promoter ID:MM_KWN:4771
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_148934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,131,989 - 79,132,489 (+)MPROMDB
RGD ID:8672526
Promoter ID:EPDNEW_M14294
Type:multiple initiation site
Name:Tpgs1_1
Description:Mus musculus tubulin polyglutamylase complex subunit 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,669,440 - 79,669,500EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106618 AgrOrtholog
Ensembl Genes ENSMUSG00000020308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020552 ENTREZGENE
  ENSMUST00000020552.8 UniProtKB/TrEMBL
  ENSMUST00000239401.2 UniProtKB/Swiss-Prot
Gene3D-CATH cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DD_TPGS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPGS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110012 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:106618 ENTREZGENE
NCBI Gene Tpgs1 ENTREZGENE
PANTHER PTHR31932 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpgs1 PhenoGen
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6Q6PKE1 ENTREZGENE, UniProtKB/TrEMBL
  B2RRP1 ENTREZGENE, UniProtKB/TrEMBL
  Q3U5Q9 ENTREZGENE
  Q99MS8 ENTREZGENE
  Q9R0B5 ENTREZGENE
  TPGS1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U5Q9 UniProtKB/Swiss-Prot
  Q9R0B5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Tpgs1  tubulin polyglutamylase complex subunit 1  Gtrgeo22  gene trap ROSA b-geo 22  Symbol and/or name change 5135510 APPROVED
2024-08-21 Gtrgeo22  gene trap ROSA b-geo 22  Tpgs1  tubulin polyglutamylase complex subunit 1  Symbol and/or name change 5135510 APPROVED
2012-11-20 Tpgs1  tubulin polyglutamylase complex subunit 1  Gm16517  predicted gene, Gm16517  Symbol and/or name change 5135510 APPROVED