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26 records found for search term Pfn1
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
621825Pfn1profilin 1ENCODES a protein that exhibits phosphatidylinositol-4,5-bisphosphate binding; signaling receptor binding; actin binding (ortholog); INVOLVED IN cellular response to growth factor stimulus; positive regulation of DNA metabolic process; positive regulation of stress fiber assembly; ASSOCIATED WITH me105586388255866587Rat231symbol , PhenoGengene, protein-coding, PROVISIONAL [RefSeq]
733332PFN1profilin 1This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded p1749456524948530Human289symbol , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
733333Pfn1profilin 1Enables small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton; modulation of chemical synaptic transmission; and synapse maturation. Acts upstream of or within neural tube closure and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucl117054267070547625Mouse291symbol , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
8982547Pfn1profilin 1ENCODES a protein that exhibits actin binding (ortholog); actin monomer binding (ortholog); adenyl-nucleotide exchange factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cellular response to growth factor stimulus (ortholog); modification of postsynaptic actin cytoskNW_0049554671035783810360651Chinchilla60symbolgene, protein-coding, MODEL [RefSeq]
11985409PFN1profilin 1ENCODES a protein that exhibits actin monomer binding (ortholog); adenyl-nucleotide exchange factor activity (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); modification of postsynaptic actin cytoskeleton (orth1749938534996811Bonobo65symbolgene, protein-coding, MODEL [RefSeq]
12417340PFN1profilin 1ENCODES a protein that exhibits phosphatidylinositol-4,5-bisphosphate binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); neural tube closure (ortholog); positive regulation of DNA metabolic process (ortholog); ASSOCIATED WIT53167048331671891Dog67symbolgene, protein-coding, MODEL [RefSeq]
12713861Pfn1profilin 1ENCODES a protein that exhibits phosphatidylinositol-4,5-bisphosphate binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); neural tube closure (ortholog); positive regulation of DNA metabolic process (ortholog); ASSOCIATED WITNW_00493667727629712766038Squirrel67symbolgene, protein-coding, MODEL [RefSeq]
13875307PFN1profilin 1ENCODES a protein that exhibits actin monomer binding (ortholog); adenyl-nucleotide exchange factor activity (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); modification of postsynaptic actin cytoskeleton (orthPig75symbolgene, protein-coding, VALIDATED [RefSeq]
18588179PFN1profilin 1ENCODES a protein that exhibits phosphatidylinositol-4,5-bisphosphate binding (ortholog); signaling receptor binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); modification of postsynaptic actin cytoskeleton (ortholog); modulationGreen Monkey67symbolgene, protein-coding, MODEL [RefSeq]
18910830Pfn1profilin 1ENCODES a protein that exhibits actin monomer binding (ortholog); adenyl-nucleotide exchange factor activity (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); modification of postsynaptic actin cytoskeleton (orthNaked Mole-Rat65symbolgene, protein-coding, MODEL [RefSeq]
155247244pfn1Tropical Clawed Frogsymbolgene, null
626150331Pfn1profilin 1ENCODES a protein that exhibits actin binding (ortholog); actin monomer binding (ortholog); adenyl-nucleotide exchange factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cellular response to growth factor stimulus (ortholog); modification of postsynaptic actin cytoskBlack Rat60symbolgene, protein-coding, MODEL [RefSeq]
155240880pfn1.LAfrican Clawed Frogsymbolgene, null
155247245pfn1.SAfrican Clawed Frogsymbolgene, null
1350272PRF1perforin 1This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or i107059734870602741Human686old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1550141Mdga2MAM domain containing glycosylphosphatidylinositol anchor 2Involved in regulation of presynapse assembly and regulation of synaptic membrane adhesion. Acts upstream of or within several processes, including motor behavior; negative regulation of neuron apoptotic process; and neuron migration. Is active in GABA-ergic synapse and glutamatergic synapse. Is exp126651283267269323Mouse115old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
5491160PFN1P1profilin 1 pseudogene 1INTERACTS WITH aristolochic acid A1171670274171671088Human1symbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
1602136PFN1P2profilin 1 pseudogene 2INTERACTS WITH 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine; bisphenol A1120432204120434109Human13symbol , COSMIC , Human Proteome Mapgene, pseudo, VALIDATED [RefSeq]
5491055PFN1P3profilin 1 pseudogene 3INTERACTS WITH cadmium dichloride1145407635145408416Human1symbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
5688832PFN1P4profilin 1 pseudogene 41148129360148130141Humansymbol , COSMIC , Human Proteome Map , old_gene_symbolgene, pseudo, INFERRED [RefSeq]
5491164PFN1P6profilin 1 pseudogene 61144442469144443250Humansymbol , COSMIC , Human Proteome Map , old_gene_symbolgene, pseudo, INFERRED [RefSeq]
6481594PFN1P8profilin 1 pseudogene 81146957261146957668Humansymbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
5688831PFN1P9profilin 1 pseudogene 9INTERACTS WITH DDT1119853205119853991Human1symbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
5491163PFN1P10profilin 1 pseudogene 1012145942421460202Humansymbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
6481546PFN1P11profilin 1 pseudogene 1110102845149102845567Humansymbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
5491162PFN1P12profilin 1 pseudogene 121143619988143620770Humansymbol , COSMIC , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]