| 62054 | Pdyn | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); INVOLVED IN locomotion involved in locomotory behavior; response to ethanol; response to immobilization stress; ASSOCIATED WITH alcohol dependence; alcohol use disorder; alcohol withdrawal syndrome; FOUND IN axon terminus; dendritic spine; dense core granule; INTERACTS WITH (R,R)-tramadol; (S)-amphetamine; 1,3-dinitrobenzene | 3 | 137354161 | 137366503 | Rat | 289 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62346 | Pdyn | prodynorphin | This gene encodes a preproprotein that is proteolytically cleaved to yield a number of active opium-like peptides. These peptides are the endogenous ligands for the Kappa-opioid receptor and similar G-protein-coupled receptors and are thought to function as the body's natural way to control addictio n. These peptides have been associated with depression, stress, anxiety, response to pain, and maintenance of homeostasis via circadian rhythms and control of appetite. Mutations in the related human gene have been linked to the neurodegenerative disease spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] | 2 | 129528469 | 129541858 | Mouse | 324 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1343954 | PDYN | prodynorphin | The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating re sponses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010] | 20 | 1978756 | 1994285 | Human | 312 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8957259 | Pdyn | prodynorphin | INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); Alcohol Withdrawal Seizures (ortholog); alcohol withdrawal syndrome (ortholog); FOUND IN axon terminus (orth olog); dendritic spine (ortholog); dense core granule (ortholog) | NW_004955415 | 13106087 | 13119497 | Chinchilla | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12042309 | PDYN | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); opioid receptor binding (inferred); INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alco hol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | 20 | 2092171 | 2108141 | Bonobo | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12118070 | PDYN | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); Alcohol Withdrawal Seizures (ortholog); alcohol withdrawal syndrome (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | 24 | 19043955 | 19057413 | Dog | 118 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12658912 | Pdyn | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); opioid receptor binding (inferred); INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alco hol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | NW_004936485 | 16559371 | 16571461 | Squirrel | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18625277 | PDYN | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); opioid receptor binding (inferred); INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alco hol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | | | | Green Monkey | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14029897 | PDYN | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | | | | Pig | 118 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625994529 | Pdyn | prodynorphin | INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | | | | Black Rat | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626179102 | pdyn | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18930146 | Pdyn | prodynorphin | ENCODES a protein that exhibits opioid peptide activity (inferred); opioid receptor binding (inferred); INVOLVED IN locomotion involved in locomotory behavior (ortholog); response to ethanol (ortholog); response to immobilization stress (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); Alco hol Withdrawal Seizures (ortholog); alcohol withdrawal syndrome (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); dense core granule (ortholog) | | | | Naked Mole-Rat | 116 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12902774 | PDYN-AS1 | PDYN antisense RNA 1 | | 20 | 1947210 | 2007517 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |