| 14376764 | pcaf-1 | | | | | | Roundworm | | symbol | gene, null |
| 1305902 | Kat2b | lysine acetyltransferase 2B | ENCODES a protein that exhibits chromatin binding; histone acetyltransferase binding; histone deacetylase binding; INVOLVED IN cellular response to oxidative stress; cellular response to parathyroid hormone stimulus; memory; PARTICIPATES IN cortisol signaling pathway; histone modification pathway; p 53 signaling pathway; ASSOCIATED WITH breast cancer (ortholog); Coronary Disease (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN chromatin; A band (ortholog); actomyosin (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; acrylamide | 9 | 6799101 | 6903616 | Rat | 308 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1314209 | KAT2B | lysine acetyltransferase 2B | CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008] | 3 | 20040446 | 20154404 | Human | 324 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314210 | Kat2b | K(lysine) acetyltransferase 2B | Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and regulation of primary metabolic process. Acts upstream of or within pos itive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 53873802 | 53979749 | Mouse | 349 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12100848 | KAT2B | lysine acetyltransferase 2B | ENCODES a protein that exhibits chromatin binding (ortholog); histone acetyltransferase binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); cellular response to parathyroid hormone stimulus (ortholog); internal peptidyl-lysine ace tylation (ortholog); PARTICIPATES IN cortisol signaling pathway; histone modification pathway; p53 signaling pathway; ASSOCIATED WITH breast cancer (ortholog); Coronary Disease (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog) | 23 | 23166722 | 23242447 | Dog | 128 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1316319 | KAT2A | lysine acetyltransferase 2A | KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] | 17 | 42113111 | 42121367 | Human | 231 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614054 | Kat2b-ps | K(lysine) acetyltransferase 2B, pseudogene | INTERACTS WITH triptonide | 5 | 93530077 | 93540939 | Mouse | 1 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1316320 | Kat2a | K(lysine) acetyltransferase 2A | Enables DNA-binding transcription factor binding activity; chromatin binding activity; and histone acetyltransferase activity. Involved in several processes, including long-term memory; positive regulation of macromolecule biosynthetic process; and regulation of regulatory T cell differentiation. Ac ts upstream of or within several processes, including brain development; chordate embryonic development; and positive regulation of gluconeogenesis. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 100595572 | 100603293 | Mouse | 340 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320985 | TAF5L | TATA-box binding protein associated factor 5 like | The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] | 1 | 229593134 | 229626122 | Human | 86 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1320986 | Taf5l | TATA-box binding protein associated factor 5 like | Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in genitourinary system and tail. Orthologous to human TAF5L (TATA-box binding protein associated factor 5 like). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 124723049 | 124748136 | Mouse | 93 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1320845 | TAF6L | TATA-box binding protein associated factor 6 like | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the r emainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008] | 11 | 62771396 | 62787342 | Human | 71 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1320846 | Taf6l | TATA-box binding protein associated factor 6 like | Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in tail. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provide d by Alliance of Genome Resources, Jul 2025] | 19 | 8751718 | 8763781 | Mouse | 67 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1313479 | TRRAP | transformation/transcription domain associated protein | This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregul ation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] | 7 | 98878532 | 99013241 | Human | 238 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1310215 | Taf5l1 | TATA-box binding protein associated factor 5 like 1 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); regulation of somatic stem cell population maintenance (ortholog); regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymer ase II transcription initiation pathway; FOUND IN nuclear speck (ortholog); nucleus (ortholog); SAGA complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A | 19 | 68889153 | 68908480 | Rat | 80 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1310123 | Taf6l | TATA-box binding protein associated factor 6 like | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); regulation of somatic stem cell population maintenance (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; FOUND IN nucleoplasm (ortholog); nucleus (ortholog); SAGA complex (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 215101266 | 215113888 | Rat | 69 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 9006379 | Taf5l | TATA-box binding protein associated factor 5 like | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); regulation of somatic stem cell population maintenance (ortholog); regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymer ase II transcription initiation pathway; FOUND IN nuclear speck (ortholog); nucleus (ortholog); SAGA complex (ortholog) | NW_004955492 | 8478147 | 8515988 | Chinchilla | 12 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 8727798 | Taf6l | TATA-box binding protein associated factor 6 like | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); regulation of somatic stem cell population maintenance (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; FOUND IN nucleoplasm (ortholog); nucleus (ortholog); SAGA complex (ortholog) | NW_004955599 | 453275 | 461571 | Chinchilla | 8 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1582831 | Taf5l-ps1 | TATA-box binding protein associated factor 5 like, pseudogene 1 | | 1 | 68563053 | 68565560 | Rat | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 1589713 | Taf5l-ps2 | TATA-box binding protein associated factor 5 like, pseudogene 2 | | 17 | 42512323 | 42515045 | Rat | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 1563991 | Taf5l2 | TATA-box binding protein associated factor 5 like 2 | | X | 39837491 | 39839297 | Rat | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1596109 | Eif2d-ps2 | eukaryotic translation initiation factor 2D, pseudogene 2 | | 6 | 88603050 | 88604931 | Rat | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 5508554 | TAF5LP1 | TATA-box binding protein associated factor 5 like pseudogene 1 | | 17 | 35498054 | 35499177 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1604249 | SGF29 | SAGA complex associated factor 29 | CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010] | 16 | 28553920 | 28591790 | Human | 104 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1320582 | TADA2A | transcriptional adaptor 2A | Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to ac etylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] | 17 | 37406886 | 37479725 | Human | 106 | description | gene, protein-coding, REVIEWED [RefSeq] |
