| 1308111 | Otud7b | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type peptidase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN in utero embryonic development (ortholog); mucosal immune response (ortholog); negative regulation of canonical NF -kappaB signal transduction (ortholog); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl | 2 | 186350811 | 186411461 | Rat | 173 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1352780 | OTUD7B | OTU deubiquitinase 7B | Enables K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of protein localization to nucleus; protein deubiquitination; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. [pro vided by Alliance of Genome Resources, Jul 2025] | 1 | 149937812 | 150067653 | Human | 156 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1617364 | Otud7b | OTU domain containing 7B | Enables K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 96011759 | 96068446 | Mouse | 180 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8726272 | Otud7b | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type peptidase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN in utero embryonic development (ortholog); mucosal immune response (ortholog); negative regulation of canonical NF -kappaB signal transduction (ortholog); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955413 | 758098 | 812605 | Chinchilla | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11951695 | OTUD7B | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); DNA binding (inferred); INVOLVED IN in utero embryonic development (ortholog); negative regulation of interleukin-8 production (ortholog); protein deubiquitination (ortholog ); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 1 | 125282599 | 125355441 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12062684 | OTUD7B | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); DNA binding (inferred); INVOLVED IN in utero embryonic development (ortholog); negative regulation of interleukin-8 production (ortholog); protein deubiquitination (ortholog ); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 17 | 59225640 | 59280875 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12726050 | Otud7b | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); DNA binding (inferred); INVOLVED IN in utero embryonic development (ortholog); negative regulation of interleukin-8 production (ortholog); protein deubiquitination (ortholog ); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | NW_004936580 | 278263 | 300278 | Squirrel | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14221177 | OTUD7B | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); DNA binding (inferred); INVOLVED IN in utero embryonic development (ortholog); negative regulation of interleukin-8 production (ortholog); protein deubiquitination (ortholog ); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915562 | Otud7b | OTU deubiquitinase 7B | ENCODES a protein that exhibits K48-linked deubiquitinase activity (ortholog); INVOLVED IN in utero embryonic development (ortholog); mucosal immune response (ortholog); negative regulation of interleukin-8 production (ortholog); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18485831 | OTUD7B | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); DNA binding (inferred); INVOLVED IN in utero embryonic development (ortholog); negative regulation of interleukin-8 production (ortholog); protein deubiquitination (ortholog ); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245081 | otud7b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625908973 | Otud7b | OTU deubiquitinase 7B | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type peptidase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN in utero embryonic development (ortholog); mucosal immune response (ortholog); negative regulation of canonical NF -kappaB signal transduction (ortholog); ASSOCIATED WITH Weight Loss (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256155 | otud7b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245080 | otud7b.S | | | | | | African Clawed Frog | | symbol | gene, null |