| 1303023 | Nudt2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasm s (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; aconitine | 5 | 61424176 | 61439018 | Rat | 86 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1352613 | NUDT2 | nudix hydrolase 2 | This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and A TP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011] | 9 | 34329569 | 34343699 | Human | 113 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550397 | Nudt2 | nudix hydrolase 2 | Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary syste m; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 41465085 | 41480926 | Mouse | 90 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9015084 | Nudt2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasm s (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | NW_004955472 | 1760046 | 1774539 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11707064 | NUDT2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (inferred); bis(5'-nucleosyl)-tetraphosphatase activity (inferred); hydrolase activity (inferred); INVOLVED IN AMP biosynthetic process (inferred); ATP biosynthetic process (inferred); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | 9 | 34165452 | 34179722 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12085292 | NUDT2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (inferred); bis(5'-nucleosyl)-tetraphosphatase activity (inferred); hydrolase activity (inferred); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficie ncy pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | 11 | 51049992 | 51064317 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12461585 | Nudt2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (inferred); bis(5'-nucleosyl)-tetraphosphatase activity (inferred); hydrolase activity (inferred); INVOLVED IN AMP biosynthetic process (inferred); ATP biosynthetic process (inferred); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | NW_004936524 | 2438947 | 2452647 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14133566 | NUDT2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; INVOLVED IN apoptotic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 37 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18923666 | Nudt2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (inferred); bis(5'-nucleosyl)-tetraphosphatase activity (inferred); hydrolase activity (inferred); INVOLVED IN AMP biosynthetic process (inferred); ATP biosynthetic process (inferred); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40896946 | NUDT2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (inferred); bis(5'-nucleosyl)-tetraphosphatase activity (inferred); hydrolase activity (inferred); INVOLVED IN AMP biosynthetic process (inferred); ATP biosynthetic process (inferred); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250083 | nudt2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626098985 | Nudt2 | nudix hydrolase 2 | ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Neoplasm s (ortholog); developmental and epileptic encephalopathy 11 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH OR WITHOUT PERIPHERAL NEUROPATHY (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252956 | nudt2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231073 | nudt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933521 | nudt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933919 | nudt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935346 | nudt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935842 | nudt2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2321725 | Nudt2-ps1 | nudix hydrolase 2, pseudogene 1 | | 11 | 93301494 | 93302842 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1305766 | Nudt21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (ortholog); mRNA 3'-end processing (ortholog); mRNA alternative poly adenylation (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; mRNA decay pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Brodifacoum | 19 | 10980797 | 10996903 | Rat | 154 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313996 | NUDT21 | nudix hydrolase 21 | The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other process ing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008] | 16 | 56429133 | 56451332 | Human | 162 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552286 | Nudt21 | nudix hydrolase 21 | Enables chromatin binding activity. Involved in positive regulation of pro-B cell differentiation; positive regulation of stem cell differentiation; and post-transcriptional regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; central ne rvous system; early embryo; respiratory system; and sensory organ. Orthologous to human NUDT21 (nudix hydrolase 21). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 94746031 | 94763667 | Mouse | 170 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8759834 | Nudt21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (ortholog); mRNA 3'-end processing (ortholog); mRNA alternative poly adenylation (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog) | NW_004955433 | 14220356 | 14234423 | Chinchilla | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11738350 | NUDT21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (inferred); histone deacetylase binding (inferred); identical protein binding (inferred); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (inferred); mRNA 3'-end processing (inferred); mRNA alternative poly adenylation (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred) | 16 | 36715373 | 36737593 | Bonobo | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12089225 | NUDT21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (inferred); histone deacetylase binding (inferred); identical protein binding (inferred); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (inferred); mRNA 3'-end processing (inferred); mRNA alternative poly adenylation (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred) | 2 | 59736739 | 59751967 | Dog | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12604430 | Nudt21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (inferred); histone deacetylase binding (inferred); identical protein binding (inferred); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (inferred); mRNA 3'-end processing (inferred); mRNA alternative poly adenylation (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred) | NW_004936475 | 8739992 | 8759165 | Squirrel | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13953905 | NUDT21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (ortholog); mRNA alternative polyadenylation (ortholog); positive re gulation of pro-B cell differentiation (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog); nuclear body (ortholog) | | | | Pig | 66 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18437547 | NUDT21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (inferred); histone deacetylase binding (inferred); identical protein binding (inferred); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (inferred); mRNA 3'-end processing (inferred); mRNA alternative poly adenylation (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred) | | | | Green Monkey | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909044 | Nudt21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (ortholog); mRNA alternative polyadenylation (ortholog); positive re gulation of pro-B cell differentiation (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234300 | nudt21 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625866742 | Nudt21 | nudix hydrolase 21 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (ortholog); mRNA 3'-end processing (ortholog); mRNA alternative poly adenylation (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog) | | | | Black Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 735224 | Nudt22 | nudix hydrolase 22 | ENCODES a protein that exhibits UDP-sugar diphosphatase activity (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 1 | 213612008 | 213615626 | Rat | 57 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1601846 | NUDT22 | nudix hydrolase 22 | Enables UDP-sugar diphosphatase activity and metal ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 64226258 | 64230269 | Human | 54 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1618361 | Nudt22 | nudix hydrolase 22 | Predicted to enable GDP-mannose hydrolase activity; UDP-sugar diphosphatase activity; and metal ion binding activity. Predicted to be located in nucleoplasm. Orthologous to human NUDT22 (nudix hydrolase 22). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 6970387 | 6973471 | Mouse | 62 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8745090 | Nudt22 | nudix hydrolase 22 | ENCODES a protein that exhibits UDP-sugar diphosphatase activity (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955422 | 20848450 | 20851913 | Chinchilla | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11857349 | NUDT22 | nudix hydrolase 22 | ENCODES a protein that exhibits GDP-mannose hydrolase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN nucleoplasm (inferred) | 11 | 59583351 | 59587187 | Bonobo | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12086565 | NUDT22 | nudix hydrolase 22 | ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); UDP-sugar diphosphatase activity (inferred); FOUND IN nucleoplasm (inferred) | 18 | 52828973 | 52831550 | Dog | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12701232 | Nudt22 | nudix hydrolase 22 | ENCODES a protein that exhibits GDP-mannose hydrolase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN nucleoplasm (inferred) | NW_004936599 | 4970522 | 4973194 | Squirrel | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14266476 | NUDT22 | nudix hydrolase 22 | ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); UDP-sugar diphosphatase activity (inferred); FOUND IN nucleoplasm (inferred) | | | | Pig | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18606528 | NUDT22 | nudix hydrolase 22 | ENCODES a protein that exhibits GDP-mannose hydrolase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN nucleoplasm (inferred) | | | | Green Monkey | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155250695 | nudt22 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625920417 | Nudt22 | nudix hydrolase 22 | ENCODES a protein that exhibits UDP-sugar diphosphatase activity (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 4 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155236846 | nudt21.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 4891984 | NUDT21P1 | nudix hydrolase 21 pseudogene 1 | | 13 | 87765607 | 87766196 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 155232462 | nudt22.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1349747 | DCP2 | decapping mRNA 2 | The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternativel y spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] | 5 | 112976798 | 113022195 | Human | 109 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 18910816 | LOC101702769 | uncharacterized LOC101702769 | | | | | Naked Mole-Rat | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16568285 | AL445647.2 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 (NUDT21) pseudogene | | | | | Human | | name | gene, processed_pseudogene |