| 1305197 | Nrl | neural retina leucine zipper | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); leucine zipper domain binding (ortholog); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of t ranscription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; all-trans-retinoic acid; bisphenol A | 15 | 32977023 | 32981442 | Rat | 91 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313083 | NRL | neural retina leucine zipper | This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retina l degenerative diseases. [provided by RefSeq, Jul 2008] | 14 | 24078662 | 24114949 | Human | 229 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313084 | Nrl | neural retina leucine zipper gene | This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012 ] | 14 | 55756973 | 55762438 | Mouse | 135 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8811340 | Nrl | neural retina leucine zipper | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); leucine zipper domain binding (ortholog); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of t ranscription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955409 | 36279996 | 36313824 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11874140 | NRL | neural retina leucine zipper | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RN A polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 14 | 4858105 | 4891207 | Bonobo | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12080349 | NRL | neural retina leucine zipper | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RN A polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 8 | 4086487 | 4090373 | Dog | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12459644 | Nrl | neural retina leucine zipper | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RN A polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936722 | 448006 | 454064 | Squirrel | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934449 | Nrl | neural retina leucine zipper | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RN A polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625842486 | Nrl | neural retina leucine zipper | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); leucine zipper domain binding (ortholog); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of t ranscription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13996417 | NRL | neural retina leucine zipper | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RN A polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH all-trans-retinoic acid | | | | Pig | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242337 | nrl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18376708 | NRL | neural retina leucine zipper | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of gene expression (ortholog); positive regulation of transcription by RN A polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH enhanced S-cone syndrome (ortholog); Foveal Hypoplasia (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255254 | nrl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257413 | nrl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 69454 | Lcn2 | lipocalin 2 | Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extrace llular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 32274649 | 32277751 | Mouse | 756 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349204 | CHRDL1 | chordin like 1 | This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009] | X | 110673856 | 110795817 | Human | 185 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1553872 | Chrdl1 | chordin-like 1 | Enables BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including BMP signaling pathway; excitatory chemical synaptic transmission; and synapse organization. Is active in extracellular region. Is expressed in several structures, including ali mentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and skeletal system. Human ortholog(s) of this gene implicated in megalocornea. Orthologous to human CHRDL1 (chordin like 1). [provided by Alliance of Genome Resources, Jul 2025] | X | 142068670 | 142177282 | Mouse | 155 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |