| 1308443 | Nkx2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN optic nerve development; response to glucose; respons e to progesterone; PARTICIPATES IN maturity-onset diabetes of the young pathway; ASSOCIATED WITH demyelinating disease; genetic disease (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 3 | 155072621 | 155083699 | Rat | 96 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318213 | NKX2-2 | NK2 homeobox 2 | The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008] | 20 | 21511017 | 21522689 | Human | 104 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318214 | Nkx2-2 | NK2 homeobox 2 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including endocrine pancreas development; neurogenesis; and positive regulation of cell differentiation. Lo cated in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural ectoderm; and sensory organ. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 146967909 | 147037270 | Mouse | 140 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8837114 | Nkx2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN astrocyte differentiation (ortholog); cell developmen t (ortholog); cell differentiation (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | NW_004955415 | 29263741 | 29268259 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11736563 | NKX2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentia tion (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | 20 | 21468872 | 21480627 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12188523 | NKX2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentia tion (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | 24 | 1933176 | 1935875 | Dog | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12443783 | Nkx2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentia tion (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | NW_004936620 | 3961106 | 3962910 | Squirrel | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626148334 | Nkx2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN astrocyte differentiation (ortholog); cell developmen t (ortholog); cell differentiation (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14047051 | NKX2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentia tion (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912676 | Nkx2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentia tion (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18741799 | NKX2-2 | NK2 homeobox 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentia tion (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250207 | nkx2-2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155250206 | nkx2-2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256390 | nkx2-2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6769737 | NKX2-2-AS1 | NKX2-2 antisense RNA 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna |
| 2314650 | Nkx2-2os | NK2 homeobox 2, opposite strand | Acts upstream of or within positive regulation of gene expression and positive regulation of oligodendrocyte differentiation. Located in cytoplasm. Orthologous to human LINC01727 (long intergenic non-protein coding RNA 1727). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 147026003 | 147173601 | Mouse | 3 | symbol , PhenoGen , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |