NKX2-2 (NK2 homeobox 2) - Rat Genome Database
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Gene: NKX2-2 (NK2 homeobox 2) Canis lupus familiaris
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Symbol: NKX2-2
Name: NK2 homeobox 2
RGD ID: 12188523
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN astrocyte differentiation (ortholog); cell development (ortholog); cell differentiation (ortholog); ASSOCIATED WITH demyelinating disease (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: homeobox protein Nkx-2.2; NK2 transcription factor related, locus 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl241,925,013 - 1,935,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1241,933,176 - 1,935,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA,ISO)

References

Genomics

Comparative Map Data
NKX2-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl241,925,013 - 1,935,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1241,933,176 - 1,935,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
NKX2-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2021,511,017 - 21,514,064 (-)EnsemblGRCh38hg38GRCh38
GRCh382021,511,010 - 21,514,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372021,491,655 - 21,494,702 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372021,491,655 - 21,494,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362021,439,648 - 21,442,664 (-)NCBINCBI36hg18NCBI36
Build 342021,439,653 - 21,442,664NCBI
Celera2021,565,531 - 21,568,547 (-)NCBI
Cytogenetic Map20p11.22NCBI
HuRef2021,453,847 - 21,456,875 (-)NCBIHuRef
CHM1_12021,491,637 - 21,494,646 (-)NCBICHM1_1
Nkx2-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,967,909 - 147,037,270 (-)NCBIGRCm39mm39
GRCm382147,176,485 - 147,195,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,177,546 - 147,194,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv372147,003,282 - 147,012,138 (-)NCBIGRCm37mm9NCBIm37
MGSCv362146,874,593 - 146,877,800 (-)NCBImm8
Celera2148,444,412 - 148,453,475 (-)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
Nkx2-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23134,619,701 - 134,630,282 (-)NCBI
Rnor_6.0 Ensembl3141,408,798 - 141,411,170 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03141,408,460 - 141,419,083 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03147,826,697 - 147,837,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43135,837,591 - 135,839,963 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13135,742,546 - 135,745,581 (-)NCBI
Celera3133,482,823 - 133,485,195 (-)NCBICelera
Cytogenetic Map3q41NCBI
Nkx2-2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541529,258,434 - 29,268,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541529,263,741 - 29,268,259 (-)NCBIChiLan1.0ChiLan1.0
NKX2-2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12021,429,388 - 21,432,492 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2021,429,401 - 21,432,492 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02021,468,872 - 21,480,627 (-)NCBIMhudiblu_PPA_v0panPan3
Nkx2-2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366203,961,106 - 3,962,910 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1729,275,682 - 29,278,606 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11729,275,656 - 29,279,572 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21733,227,964 - 33,230,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1250,499,802 - 50,511,309 (-)NCBI
ChlSab1.1 Ensembl250,500,691 - 50,502,438 (-)Ensembl
Nkx2-2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474121,857,911 - 21,860,128 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 7 6
Low 5 6 5 4
Below cutoff 1 3 2 3 2 3 3 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008335   ⟹   ENSCAFP00000007724
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl241,925,013 - 1,935,874 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078494   ⟹   ENSCAFP00000063267
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl241,925,013 - 1,935,874 (+)Ensembl
RefSeq Acc Id: XM_014107317   ⟹   XP_013962792
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1241,933,918 - 1,935,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_542867   ⟹   XP_542867
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1241,933,176 - 1,935,875 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_542867   ⟸   XM_542867
- Peptide Label: isoform X1
- UniProtKB: E2RNP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013962792   ⟸   XM_014107317
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000063267   ⟸   ENSCAFT00000078494
RefSeq Acc Id: ENSCAFP00000007724   ⟸   ENSCAFT00000008335
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005173 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000007724 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000063267 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008335 UniProtKB/TrEMBL
  ENSCAFT00000078494 UniProtKB/TrEMBL
InterPro Homeobox-like UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
NCBI Gene NKX2-2 ENTREZGENE
Pfam Homeobox UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A5F4D951_CANLF UniProtKB/TrEMBL
  E2RNP4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43833 ENTREZGENE