Nkx2-2 (NK2 homeobox 2) - Rat Genome Database

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Gene: Nkx2-2 (NK2 homeobox 2) Mus musculus
Analyze
Symbol: Nkx2-2
Name: NK2 homeobox 2
RGD ID: 1318214
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including enteroendocrine cell differentiation; neurogenesis; and positive regulation of cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural ectoderm; and sensory organ. Orthologous to human NKX2-2 (NK2 homeobox 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Drosophila NK2 transcription factor related, locus 2; glycoprotein GP330, renal; homeobox protein NK-2 homolog B; homeobox protein Nkx-2.2; homeobox protein Nkx2-2; NK2 transcription factor related, locus 2; Nkx-2.; Nkx-2.2; Nkx2.; Nkx2.2; ti; tinman
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,967,909 - 147,037,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2147,019,466 - 147,036,163 (-)EnsemblGRCm39 Ensembl
GRCm382147,176,485 - 147,195,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,177,546 - 147,194,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv372147,003,282 - 147,012,138 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362146,874,593 - 146,877,800 (-)NCBIMGSCv36mm8
Celera2148,444,412 - 148,453,475 (-)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Bertuzzi S, etal., Genes Dev 1999 Dec 1;13(23):3092-105.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination. Watanabe M, etal., Glia. 2004 May;46(3):311-22.
Additional References at PubMed
PMID:1346742   PMID:7939711   PMID:8565076   PMID:8575293   PMID:8654958   PMID:9230312   PMID:9344671   PMID:9347917   PMID:9545546   PMID:9584121   PMID:9585504   PMID:9636069  
PMID:9655799   PMID:9828088   PMID:9832510   PMID:9865699   PMID:9886035   PMID:10101124   PMID:10217145   PMID:10230789   PMID:10349636   PMID:10357893   PMID:10395791   PMID:10471501  
PMID:10471502   PMID:10482234   PMID:10516314   PMID:10557208   PMID:10603087   PMID:10615124   PMID:10704382   PMID:10719888   PMID:10725236   PMID:10830170   PMID:10903178   PMID:10934027  
PMID:11042159   PMID:11060228   PMID:11060242   PMID:11071781   PMID:11076756   PMID:11076772   PMID:11076861   PMID:11125038   PMID:11161479   PMID:11180810   PMID:11217851   PMID:11239429  
PMID:11291866   PMID:11306624   PMID:11449277   PMID:11502253   PMID:11526078   PMID:11566099   PMID:11567614   PMID:11567616   PMID:11744384   PMID:11748151   PMID:11784021   PMID:11830569  
PMID:11886853   PMID:11955448   PMID:11960707   PMID:12015293   PMID:12189445   PMID:12361967   PMID:12426319   PMID:12435628   PMID:12435629   PMID:12466851   PMID:12477932   PMID:12490199  
PMID:12571110   PMID:12595239   PMID:12604598   PMID:12636919   PMID:12651891   PMID:12787506   PMID:12812795   PMID:12837627   PMID:12842915   PMID:12874134   PMID:12897786   PMID:12915306  
PMID:12933680   PMID:12954718   PMID:14504237   PMID:14517990   PMID:14534138   PMID:14570708   PMID:14573534   PMID:14602683   PMID:14602809   PMID:14603322   PMID:14648547   PMID:14651936  
PMID:14660441   PMID:14701942   PMID:14723851   PMID:14729487   PMID:14970313   PMID:14973276   PMID:15031110   PMID:15071116   PMID:15075292   PMID:15105370   PMID:15105374   PMID:15133515  
PMID:15215207   PMID:15218525   PMID:15229603   PMID:15236237   PMID:15240555   PMID:15240886   PMID:15326611   PMID:15342729   PMID:15548585   PMID:15576403   PMID:15576405   PMID:15618518  
PMID:15629702   PMID:15691760   PMID:15789444   PMID:15793245   PMID:15804564   PMID:15880651   PMID:15893981   PMID:15930098   PMID:15930104   PMID:15976074   PMID:16020526   PMID:16055717  
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PMID:16330018   PMID:16339193   PMID:16357211   PMID:16364285   PMID:16406324   PMID:16407399   PMID:16432183   PMID:16459298   PMID:16469306   PMID:16571630   PMID:16571633   PMID:16602821  
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PMID:19285468   PMID:19286674   PMID:19287388   PMID:19298856   PMID:19334287   PMID:19357274   PMID:19386638   PMID:19389377   PMID:19439492   PMID:19502415   PMID:19542360   PMID:19549984  
PMID:19592253   PMID:19592574   PMID:19607821   PMID:19619492   PMID:19723505   PMID:19741146   PMID:19759004   PMID:19766572   PMID:19767740   PMID:19776033   PMID:19777589   PMID:19780200  
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PMID:21377456   PMID:21382552   PMID:21490060   PMID:21529712   PMID:21533046   PMID:21552265   PMID:21565611   PMID:21576465   PMID:21624811   PMID:21664576   PMID:21669943   PMID:21674568  
PMID:21677750   PMID:21698205   PMID:21731673   PMID:21750036   PMID:21752929   PMID:21761479   PMID:21763481   PMID:21775418   PMID:21791528   PMID:21852533   PMID:21856296   PMID:21873635  
PMID:21880149   PMID:21912524   PMID:21943603   PMID:22007132   PMID:22013016   PMID:22056672   PMID:22071102   PMID:22102297   PMID:22179047   PMID:22182519   PMID:22265416   PMID:22383895  
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PMID:23673330   PMID:23700466   PMID:23756022   PMID:23773994   PMID:23852729   PMID:23900540   PMID:23903190   PMID:23940571   PMID:23955340   PMID:23996959   PMID:24007338   PMID:24009262  
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PMID:31081019   PMID:31235634   PMID:31249377   PMID:31291587   PMID:31336385   PMID:31345937   PMID:31412250   PMID:31461644   PMID:31607856   PMID:31872525   PMID:31932307   PMID:31964774  
PMID:32129762   PMID:32266943   PMID:32420617   PMID:32450295   PMID:32561725   PMID:32568216   PMID:32675279   PMID:32701653   PMID:32702291   PMID:32758357   PMID:32938678   PMID:32943498  
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PMID:34104947   PMID:34201511   PMID:34321664   PMID:34478646   PMID:34486668   PMID:34645928   PMID:34752747   PMID:35177643   PMID:35210288   PMID:35353806   PMID:35399523   PMID:35815619  
PMID:35839257   PMID:36476860   PMID:36529318   PMID:36669111   PMID:37298722   PMID:37315133   PMID:37364986   PMID:37524711   PMID:37684687   PMID:37738262   PMID:37943875   PMID:38036964  
PMID:38160393   PMID:38171360   PMID:38265933   PMID:38344749   PMID:38507412   PMID:38546197   PMID:38636517   PMID:38696583  


Genomics

Comparative Map Data
Nkx2-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,967,909 - 147,037,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2147,019,466 - 147,036,163 (-)EnsemblGRCm39 Ensembl
GRCm382147,176,485 - 147,195,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,177,546 - 147,194,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv372147,003,282 - 147,012,138 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362146,874,593 - 146,877,800 (-)NCBIMGSCv36mm8
Celera2148,444,412 - 148,453,475 (-)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
NKX2-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382021,511,017 - 21,522,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2021,511,017 - 21,514,064 (-)EnsemblGRCh38hg38GRCh38
GRCh372021,491,655 - 21,503,327 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362021,439,648 - 21,442,664 (-)NCBINCBI36Build 36hg18NCBI36
Build 342021,439,653 - 21,442,664NCBI
Celera2021,565,531 - 21,568,547 (-)NCBICelera
Cytogenetic Map20p11.22NCBI
HuRef2021,453,847 - 21,456,875 (-)NCBIHuRef
CHM1_12021,491,637 - 21,494,646 (-)NCBICHM1_1
T2T-CHM13v2.02021,567,657 - 21,579,329 (-)NCBIT2T-CHM13v2.0
Nkx2-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83155,072,621 - 155,083,699 (-)NCBIGRCr8
mRatBN7.23134,619,701 - 134,630,282 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3134,620,039 - 134,622,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3138,534,251 - 138,536,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03147,118,346 - 147,120,711 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03144,821,505 - 144,823,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03141,408,460 - 141,419,083 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3141,408,798 - 141,411,170 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03147,826,697 - 147,837,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43135,837,591 - 135,839,963 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13135,742,546 - 135,745,581 (-)NCBI
Celera3133,482,823 - 133,485,195 (-)NCBICelera
Cytogenetic Map3q41NCBI
Nkx2-2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541529,258,434 - 29,268,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541529,263,741 - 29,268,259 (-)NCBIChiLan1.0ChiLan1.0
NKX2-2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,399,629 - 22,411,892 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12022,396,969 - 22,408,717 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02021,468,872 - 21,480,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12021,429,388 - 21,432,492 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2021,429,401 - 21,432,492 (-)Ensemblpanpan1.1panPan2
NKX2-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1241,933,176 - 1,935,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl241,925,013 - 1,935,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha241,958,452 - 1,961,136 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,337,619 - 2,340,304 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,329,436 - 2,340,303 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1241,934,805 - 1,937,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,037,841 - 2,040,531 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0242,314,779 - 2,317,463 (+)NCBIUU_Cfam_GSD_1.0
Nkx2-2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640150,540,634 - 150,543,333 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366203,961,106 - 3,969,503 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366203,961,106 - 3,962,910 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1729,275,698 - 29,278,606 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11729,275,656 - 29,279,572 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21733,227,964 - 33,230,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1250,499,802 - 50,511,309 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl250,500,691 - 50,502,438 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660785,299,009 - 5,310,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkx2-2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474121,852,205 - 21,860,040 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474121,857,911 - 21,860,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nkx2-2
1939 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:895
Count of miRNA genes:487
Interacting mature miRNAs:569
Transcripts:ENSMUST00000067075, ENSMUST00000109969, ENSMUST00000109970, ENSMUST00000172627
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
BB262845  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382147,177,582 - 147,177,721UniSTSGRCm38
MGSCv372147,003,318 - 147,003,457UniSTSGRCm37
Celera2148,444,448 - 148,444,587UniSTS
Cytogenetic Map2HUniSTS
cM Map282.0UniSTS
Whitehead/MRC_RH21739.29UniSTS
Nkx2-2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382147,183,904 - 147,184,417UniSTSGRCm38
MGSCv372147,009,640 - 147,010,153UniSTSGRCm37
Celera2148,450,809 - 148,451,322UniSTS
Cytogenetic Map2HUniSTS
cM Map2 UniSTS
PMC123023P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382147,184,123 - 147,184,310UniSTSGRCm38
MGSCv372147,009,859 - 147,010,046UniSTSGRCm37
Celera2148,451,028 - 148,451,215UniSTS
Cytogenetic Map2HUniSTS
cM Map282.0UniSTS
Nkx2-2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2HUniSTS
Nkx2-2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2HUniSTS
cM Map2 UniSTS
Nkx2-2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382147,185,806 - 147,186,016UniSTSGRCm38
MGSCv372147,011,542 - 147,011,752UniSTSGRCm37
Cytogenetic Map2HUniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001077632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011239349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF229632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB183898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S83259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000067075   ⟹   ENSMUSP00000069666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2147,025,003 - 147,028,324 (-)Ensembl
GRCm38.p6 Ensembl2147,183,083 - 147,186,404 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109969
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2147,028,225 - 147,036,163 (-)Ensembl
GRCm38.p6 Ensembl2147,186,305 - 147,194,243 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109970   ⟹   ENSMUSP00000105596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2147,019,466 - 147,028,021 (-)Ensembl
GRCm38.p6 Ensembl2147,177,546 - 147,186,101 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172627
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2147,028,302 - 147,036,162 (-)Ensembl
GRCm38.p6 Ensembl2147,186,382 - 147,194,242 (-)Ensembl
RefSeq Acc Id: NM_001077632   ⟹   NP_001071100
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,019,447 - 147,028,325 (-)NCBI
GRCm382147,177,546 - 147,186,402 (-)NCBI
MGSCv372147,003,282 - 147,012,138 (-)RGD
Celera2148,444,412 - 148,453,475 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001420453   ⟹   NP_001407382
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,019,447 - 147,036,165 (-)NCBI
RefSeq Acc Id: NM_010919   ⟹   NP_035049
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,025,008 - 147,028,325 (-)NCBI
GRCm382147,183,152 - 147,186,402 (-)NCBI
MGSCv372147,003,282 - 147,012,138 (-)RGD
Celera2148,444,412 - 148,453,475 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498899   ⟹   XP_006498962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,025,003 - 147,036,432 (-)NCBI
GRCm382147,176,485 - 147,194,270 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498900   ⟹   XP_006498963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,025,003 - 147,037,270 (-)NCBI
GRCm382147,176,485 - 147,195,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011239349   ⟹   XP_011237651
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,025,003 - 147,036,463 (-)NCBI
GRCm382147,176,485 - 147,194,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159325   ⟹   XP_036015218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,025,003 - 147,036,163 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159329   ⟹   XP_036015222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392146,967,909 - 147,036,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159330   ⟹   XP_036015223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,018,405 - 147,036,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159331   ⟹   XP_036015224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,019,011 - 147,036,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159335   ⟹   XP_036015228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,019,011 - 147,036,163 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159341   ⟹   XP_036015234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,019,011 - 147,036,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159345   ⟹   XP_036015238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,006,146 - 147,036,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159347   ⟹   XP_036015240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,019,896 - 147,036,190 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004938823
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392147,018,405 - 147,036,163 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035049   ⟸   NM_010919
- Peptide Label: isoform 1
- UniProtKB: P42586 (UniProtKB/Swiss-Prot),   Q3URZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001071100   ⟸   NM_001077632
- Peptide Label: isoform 2
- UniProtKB: Q8BRS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498963   ⟸   XM_006498900
- Peptide Label: isoform X1
- UniProtKB: P42586 (UniProtKB/Swiss-Prot),   Q3URZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498962   ⟸   XM_006498899
- Peptide Label: isoform X1
- UniProtKB: P42586 (UniProtKB/Swiss-Prot),   Q3URZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237651   ⟸   XM_011239349
- Peptide Label: isoform X1
- UniProtKB: P42586 (UniProtKB/Swiss-Prot),   Q3URZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000069666   ⟸   ENSMUST00000067075
Ensembl Acc Id: ENSMUSP00000105596   ⟸   ENSMUST00000109970
RefSeq Acc Id: XP_036015222   ⟸   XM_036159329
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036015238   ⟸   XM_036159345
- Peptide Label: isoform X5
RefSeq Acc Id: XP_036015223   ⟸   XM_036159330
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036015234   ⟸   XM_036159341
- Peptide Label: isoform X4
- UniProtKB: Q8BRS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036015224   ⟸   XM_036159331
- Peptide Label: isoform X4
- UniProtKB: Q8BRS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036015228   ⟸   XM_036159335
- Peptide Label: isoform X4
- UniProtKB: Q8BRS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036015240   ⟸   XM_036159347
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036015218   ⟸   XM_036159325
- Peptide Label: isoform X1
- UniProtKB: P42586 (UniProtKB/Swiss-Prot),   Q3URZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001407382   ⟸   NM_001420453
- Peptide Label: isoform 3
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42586-F1-model_v2 AlphaFold P42586 1-273 view protein structure

Promoters
RGD ID:6879036
Promoter ID:EPDNEW_M2969
Type:multiple initiation site
Name:Nkx2-2_1
Description:Mus musculus NK2 homeobox 2 (Nkx2-2), transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382147,186,405 - 147,186,465EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97347 AgrOrtholog
Ensembl Genes ENSMUSG00000027434 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067075 ENTREZGENE
  ENSMUST00000067075.7 UniProtKB/Swiss-Prot
  ENSMUST00000109970 ENTREZGENE
  ENSMUST00000109970.5 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_NK-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18088 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97347 ENTREZGENE
NCBI Gene 18088 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-2.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN VND-RELATED UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nkx2-2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NKX22_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TRC3_MOUSE UniProtKB/TrEMBL
  Q3URZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q8BRS9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Nkx2-2  NK2 homeobox 2    NK2 transcription factor related, locus 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED