| 1557971 | Nkx1-1 | NK1 homeobox 1 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system process; regulation of generation of precursor metaboli tes and energy; and regulation of glucose metabolic process. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human NKX1-1 (NK1 homeobox 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 33588078 | 33591434 | Mouse | 22 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1564874 | Nkx1-1 | NK1 homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH bisphenol A; 4,4'-sulfonyldiphenol (ortholog); isoflurane (ortholog) | 14 | 81521206 | 81524788 | Rat | 20 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1603306 | NKX1-1 | NK1 homeobox 1 | This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coord inated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017] | 4 | 1402932 | 1406442 | Human | 20 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8772998 | Nkx1-1 | NK1 homeobox 1 | INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog) | NW_004955514 | 763160 | 781635 | Chinchilla | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11741546 | NKX1-1 | NK1 homeobox 1 | INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog) | 4 | 1547939 | 1551457 | Bonobo | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12288232 | NKX1-1 | NK1 homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred) | 3 | 62634654 | 62638111 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12441566 | Nkx1-1 | NK1 homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog ); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred) | NW_004936477 | 21909542 | 21910599 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929960 | Nkx1-1 | NK1 homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog ); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626150501 | Nkx1-1 | NK1 homeobox 1 | INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13862142 | NKX1-1 | NK1 homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239766 | nkx1-1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18404450 | NKX1-1 | NK1 homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog ); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243279 | nkx1-1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239765 | nkx1-1.S | | | | | | African Clawed Frog | | symbol | gene, null |
