| 1309055 | Ngef | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN ephrin receptor signaling pathway (ortholog); negative regulation of dendritic spine morphogenesis (ortholog); regulation of synapse pruning (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse; glutamatergic synapse (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol | 9 | 95594823 | 95692381 | Rat | 170 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319181 | NGEF | neuronal guanine nucleotide exchange factor | Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in ephrin receptor signaling pathway; regulation of actin cytoskeleton organization; and regulation of synapse organization. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse and postsynaps e. [provided by Alliance of Genome Resources, Apr 2025] | 2 | 232878701 | 233013256 | Human | 169 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1319182 | Ngef | neuronal guanine nucleotide exchange factor | Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and regulation of synapse pruning. Is active in glutamatergic synapse. Is expressed in several structures, including brain; chondrocranium; genitourinary sys tem; heart valve; and liver. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 87404551 | 87501661 | Mouse | 166 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8719271 | Ngef | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN ephrin receptor signaling pathway (ortholog); negative regulation of dendritic spine morphogenesis (ortholog); regulation of synapse pruning (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | NW_004955453 | 3082826 | 3186039 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11861331 | NGEF | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cell differentiation (inferred); ephrin receptor signaling pathway (inferred); negative regulation of dendritic spine morphogenesis (inferred); PARTICIPATES IN ephri n - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse (ortholog) | 2B | 120110441 | 120153934 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12347530 | NGEF | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cell differentiation (inferred); ephrin receptor signaling pathway (inferred); negative regulation of dendritic spine morphogenesis (inferred); PARTICIPATES IN ephri n - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse (ortholog) | 25 | 44473422 | 44547838 | Dog | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12446768 | Ngef | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cell differentiation (inferred); ephrin receptor signaling pathway (inferred); negative regulation of dendritic spine morphogenesis (inferred); PARTICIPATES IN ephri n - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse (ortholog) | NW_004936525 | 4250389 | 4282041 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14046816 | NGEF | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cell differentiation (inferred); ephrin receptor signaling pathway (inferred); negative regulation of dendritic spine morphogenesis (inferred); PARTICIPATES IN ephri n - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse (ortholog) | | | | Pig | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18357982 | NGEF | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cell differentiation (inferred); ephrin receptor signaling pathway (inferred); negative regulation of dendritic spine morphogenesis (inferred); PARTICIPATES IN ephri n - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse (ortholog) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242230 | ngef | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18918492 | Ngef | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cell differentiation (inferred); ephrin receptor signaling pathway (inferred); negative regulation of dendritic spine morphogenesis (inferred); PARTICIPATES IN ephri n - ephrin receptor bidirectional signaling axis; FOUND IN postsynapse (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625846784 | Ngef | neuronal guanine nucleotide exchange factor | ENCODES a protein that exhibits ephrin receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN ephrin receptor signaling pathway (ortholog); negative regulation of dendritic spine morphogenesis (ortholog); regulation of synapse pruning (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866242 | NGEF | neuronal guanine nucleotide exchange factor | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155249099 | ngef.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242229 | ngef.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16552502 | AC106876.1 | novel transcript, antisense to NGEF | | 2 | 233012614 | 233015885 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |